Patents by Inventor Kevin Turner
Kevin Turner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240117322Abstract: A recombinant adeno-associated virus (rAAV) vector comprising an AAVhu68 capsid produced in a production system comprising a nucleotide sequence of SEQ ID NO: 1, or a sequence at least 75% identical thereto which encodes SEQ ID NO:2. The AAVhu68 capsid comprises subpopulations of highly deamidated asparagine residues in asparagine-glycine pairs in the amino acid sequence of SEQ ID NO: 2. Also provided are compositions containing the rAAV and uses thereof. Additionally, rAAV having an engineered AAV capsid comprising at least one subpopulation of vp1 or vp2 proteins having a Val at amino acid position 157 with reference to the AAVhu68 vp1 numbering are provided.Type: ApplicationFiled: October 11, 2023Publication date: April 11, 2024Applicant: The Trustees of the University of PennsylvaniaInventors: James M. Wilson, Qiang Wang, April Tepe, Kevin Turner
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Patent number: 11953982Abstract: Embodiments include in response to monitoring a processor during operation, detecting a first number of core recovery events in the processor, determining that the first number of core recovery events fulfills a first condition for the first core recovery events threshold, and modifying a value of at least one droop sensor parameter of the processor by a first amount. The at least one droop sensor parameters affects a sensitivity to a voltage droop. In response to modifying the value of the droop sensor parameter by the first amount, a second number of core recovery events is detected in the processor. It is determined that the second number of core recovery events fulfills a second condition for a second core recovery events threshold, and the value of the at least one droop sensor parameter is modified by a second amount.Type: GrantFiled: July 19, 2022Date of Patent: April 9, 2024Assignee: International Business Machines CorporationInventors: Alejandro Alberto Cook Lobo, Andrew A. Turner, Christian Jacobi, Eberhard Engler, Edward C. McCain, Kevin P. Low, Phillip John Restle, Pradeep Bhadravati Parashurama, Tobias Webel, Alper Buyuktosunoglu, Karl Evan Smock Anderson, Sean Michael Carey, Kennedy Cheruiyot, Daniel Kiss, Isidore G. Bendrihem, Ian Krispin Carmichael
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Patent number: 11827906Abstract: A recombinant adeno-associated virus (rAAV) vector comprising an AAVhu68 capsid produced in a production system comprising a nucleotide sequence of SEQ ID NO: 1, or a sequence at least 75% identical thereto which encodes SEQ ID NO:2. The AAVhu68 capsid comprises subpopulations of highly deamidated asparagine residues in asparagine-glycine pairs in the amino acid sequence of SEQ ID NO: 2. Also provided are compositions containing the rAAV and uses thereof. Additionally, rAAV having an engineered AAV capsid comprising at least one subpopulation of vp1 or vp2 proteins having a Val at amino acid position 157 with reference to the AAVhu68 vp1 numbering are provided.Type: GrantFiled: February 27, 2018Date of Patent: November 28, 2023Assignee: The Trustees of the University of PennsylvaniaInventors: James M. Wilson, Qiang Wang, April Tepe, Kevin Turner
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Patent number: 11543306Abstract: Provided are structurally-reconfigurable, optical metasurfaces constructed by, for example, integrating a plasmonic lattice array in the gap between a pair of microbodies that serve to locally amplify the strain created on an elastomeric substrate by an external mechanical stimulus. The spatial arrangement and therefore the optical response of the plasmonic lattice array is reversible.Type: GrantFiled: September 21, 2020Date of Patent: January 3, 2023Assignee: The Trustees of the University of PennsylvaniaInventors: Cherie R. Kagan, Kevin Turner, Wenxiang Chen, Yijie Jiang
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Patent number: 11535006Abstract: An apparatus for manipulating an object includes a substrate, an electrically conductive layer disposed on the substrate, and a porous medium comprising an electrically conductive material. The apparatus also includes a dielectric layer conformally disposed on the porous medium to insulate the porous medium from the object during use. The porosity of the porous medium is about 90% or greater. The adhesive strength of the porous medium is about 1 kPa or lower, and the modulus of the porous medium is about 1 GPa or lower.Type: GrantFiled: January 5, 2018Date of Patent: December 27, 2022Assignee: Massachusetts Institute of TechnologyInventors: Sanha Kim, Anastasios John Hart, Kevin Turner, Yijie Jiang
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Publication number: 20220100919Abstract: A method of analyzing a blended airfoil that includes generating a plurality of simulated blended airfoil designs each including one of a plurality of blend geometries, training surrogate models representing the plurality of simulated blended airfoil designs based on natural frequency, modal force, and Goodman scale factors, determining a likelihood of operational failure of each of the plurality of blended airfoil designs in response to one or more vibratory modes, determining which of the plurality of simulated blended airfoil designs violate at least one aeromechanical constraint and generating, a blend design space visualization including a blend design space, where the blend design space includes one or more restricted regions indicating blended airfoil designs where at least one aeromechanical constraint is violates and one or more permitted regions indicating blended airfoil designs where no aeromechanical constraints are violated.Type: ApplicationFiled: April 16, 2021Publication date: March 31, 2022Applicant: General Electric CompanyInventors: Suryarghya Chakrabarti, Kevin Turner, Yoon Seok Choi, Douglas L. Washburn, Liping Wang, Andrew J. Blair
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Patent number: 11260642Abstract: Disclosed herein are embodiments of methods that utilize dry adhesion tuning of a composite structure to adhere substrates. In some embodiments, the disclosed methods utilize dry adhesion between a composite structure and a substrate and further dynamically control the resulting dry adhesion strength through a heating step, which facilitates rigidity tuning of a core component of the composite structure and/or facilitates thermal control of the interface between the substrate and the composite structure. Also disclosed herein are array devices and other products comprising the disclosed composite structures.Type: GrantFiled: January 31, 2018Date of Patent: March 1, 2022Assignees: Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada, Reno, The Trustees of the University of PennsylvaniaInventors: Wanliang Shan, Kevin Turner
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Publication number: 20210123073Abstract: A recombinant adeno-associated virus (rAAV) vector comprising an AAV capsid having a heterogeneous population of vp1 proteins, a heterogeneous population of vp2 protein and a heterogeneous population of vp3 proteins. The capsid contains modified amino acids as compared to the encoded VP1 amino acid sequence, the capsid containing highly deamidated asparagine residues at asparagine-glycine pair, and further comprising multiple other, less deamidated asparagine and optionally glutamine residues.Type: ApplicationFiled: February 27, 2019Publication date: April 29, 2021Inventors: James M. Wilson, April Tepe, Kevin Turner, Joshua Joyner Sims, Qiang Wang
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Publication number: 20210088392Abstract: Provided are structurally-reconfigurable, optical metasurfaces constructed by, for example, integrating a plasmonic lattice array in the gap between a pair of microbodies that serve to locally amplify the strain created on an elastomeric substrate by an external mechanical stimulus. The spatial arrangement and therefore the optical response of the plasmonic lattice array is reversible.Type: ApplicationFiled: September 21, 2020Publication date: March 25, 2021Inventors: Cherie Kagan, Kevin Turner, Wenxiang Chen, Yijie Jiang
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Publication number: 20200407750Abstract: A recombinant adeno-associated virus (rAAV) vector comprising an AAV capsid having a heterogeneous population of vp1 proteins, a heterogeneous population of vp2 protein and a heterogeneous population of vp3 proteins. The capsid contains modified amino acids as compared to the encoded VP1 amino acid sequence, the capsid containing highly deamidated asparagine residues at asparagine-glycine pair, and further comprising multiple other, less deamidated asparagine and optionally glutamine residues. Methods of reducing deamidation in the AAV capsid of a rAAV are provided.Type: ApplicationFiled: February 27, 2019Publication date: December 31, 2020Inventors: James M. Wilson, April Tepe, Kevin Turner, Joshua Joyner Sims
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Publication number: 20200254718Abstract: An apparatus for manipulating an object includes a substrate, an electrically conductive layer disposed on the substrate, and a porous medium comprising an electrically conductive material. The apparatus also includes a dielectric layer conformally disposed on the porous medium to insulate the porous medium from the object during use. The porosity of the porous medium is about 90% or greater. The adhesive strength of the porous medium is about 1 kPa or lower, and the modulus of the porous medium is about 1 GPa or lower.Type: ApplicationFiled: January 5, 2018Publication date: August 13, 2020Inventors: Sanha Kim, Anastasios John Hart, Kevin Turner, Yijie Jiang
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Publication number: 20200056159Abstract: A recombinant adeno-associated virus (rAAV) vector comprising an AAVhu68 capsid produced in a production system comprising a nucleotide sequence of SEQ ID NO: 1, or a sequence at least 75% identical thereto which encodes SEQ ID NO:2. The AAVhu68 capsid comprises subpopulations of highly deamidated asparagine residues in asparagine glycine pairs in the amino acid sequence of SEQ ID NO: 2. Also provided are compositions containing the rAAV and uses thereof. Additionally, rAAV having an engineered AAV capsid comprising at least one subpopulation of vp1 or vp2 proteins having a Val at amino acid position 157 with reference to the AAVhu68 vp1 numbering are provided.Type: ApplicationFiled: February 27, 2018Publication date: February 20, 2020Inventors: James M. Wilson, Qiang Wang, April GIles, Kevin Turner
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Patent number: 10549483Abstract: A structured composite surface includes a backing layer and a plurality of composite posts in contact with the backing layer, each composite post having a core made of a first material and an outer shell made of a second material, the outer shell is in contact with and surrounding the core, the core has a Young's modulus of at least 50 times greater than the outer shell. A method of transfer printing includes pressing a stamp including at least one composite post to a substrate, the at least one composite post having a core made of a first material and an outer shell made of a second material, the outer shell is in contact with and surrounding the core, the core has a Young's modulus at least 50 times greater than the outer shell, and retracting the stamp from the substrate by applying a shear load to the stamp.Type: GrantFiled: May 28, 2015Date of Patent: February 4, 2020Assignee: The Trustees of the University of PennsylvaniaInventors: Kevin Turner, Helen Minsky
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Publication number: 20200023628Abstract: Disclosed herein are embodiments of methods that utilize dry adhesion tuning of a composite structure to adhere substrates. In some embodiments, the disclosed methods utilize dry adhesion between a composite structure and a substrate and further dynamically control the resulting dry adhesion strength through a heating step, which facilitates rigidity tuning of a core component of the composite structure and/or facilitates thermal control of the interface between the substrate and the composite structure. Also disclosed herein are array devices and other products comprising the disclosed composite structures.Type: ApplicationFiled: January 31, 2018Publication date: January 23, 2020Applicants: Board of Regents of the Nevada System of Higher Ed., on behalf of the Univ. of Nevada, Reno, The Trustees of the University of PennsylvaniaInventors: Wanliang Shan, Kevin Turner
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Publication number: 20170087763Abstract: A structured composite surface includes a backing layer and a plurality of composite posts in contact with the backing layer, each composite post having a core made of a first material and an outer shell made of a second material, the outer shell is in contact with and surrounding the core, the core has a Young's modulus of at least 50 times greater than the outer shell. A method of transfer printing includes pressing a stamp including at least one composite post to a substrate, the at least one composite post having a core made of a first material and an outer shell made of a second material, the outer shell is in contact with and surrounding the core, the core has a Young's modulus at least 50 times greater than the outer shell, and retracting the stamp from the substrate by applying a shear load to the stamp.Type: ApplicationFiled: May 28, 2015Publication date: March 30, 2017Applicant: The Trustees of the University of PennsylvaniaInventors: Kevin TURNER, Helen Minsky
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Patent number: 9054436Abstract: In one embodiment, a method of fabrication of a stimulation lead for electrical stimulation of tissue of a patient, the method comprises: providing a substrate of non-conductive material for a stimulation portion of the stimulation lead; processing the substrate to create a plurality of recessed features into a surface of the substrate, wherein the plurality of recessed features comprise a plurality of paths for electrical traces and a plurality of surfaces for electrodes with each of the surfaces being connected to one of the traces; providing first conductive material over the surface of the substrate; subjecting the surface of the substrate to mechanical processing to remove conductive material from portions of the substrate disposed above the plurality of recessed features, wherein each respective connected electrode and trace is electrically isolated from the other electrodes and traces after the mechanical processing; electrically plating second conductive material over the first conductive material; prType: GrantFiled: September 30, 2010Date of Patent: June 9, 2015Assignee: Advanced Neuromodulation Systems, Inc.Inventors: John Swanson, Kevin Turner, Jerome Boogaard
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Patent number: 8925191Abstract: In one embodiment, a method of fabrication of a stimulation lead comprising a plurality of segmented electrodes for stimulation of tissue of a patient, the method comprises: providing an elongated, substantially cylindrical substrate, the substrate comprising a plurality of recesses defined in an outer surface of the substrate; coating the substrate with conductive material; patterning conductive material on the substrate to form a plurality of electrode surfaces for at least the plurality of segmented electrodes and a plurality of traces connected to the plurality of electrode surfaces, wherein each electrode surface and its corresponding trace are defined in the recesses on the outer surface of the substrate and are electrically isolated from other electrode surfaces and traces; providing insulative material over at least the plurality of traces; and electrically coupling the plurality of traces to conductive wires of a lead body.Type: GrantFiled: April 18, 2012Date of Patent: January 6, 2015Assignee: Advanced Neuromodulation Systems, Inc.Inventors: John Swanson, Kevin Turner, Jerome Boogaard
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Publication number: 20140130349Abstract: In one embodiment, a method of fabrication of a stimulation lead comprising a plurality of segmented electrodes for stimulation of tissue of a patient, the method comprises: providing a substrate comprising (i) a substantially cylindrical body and (ii) a plurality of projections extending radially from the cylindrical body; coating the substrate with first conductive material; patterning the first conductive material on the cylindrical body into a plurality of traces, the plurality of traces extending along the cylindrical body and electrically contacting conductive material about the plurality of projections; providing an insulative layer over the traces; coating the insulative layer over the traces with second conductive material; patterning the second conductive material to form at least a plurality of electrode surfaces including a plurality of segmented electrodes, the segmented electrodes being in electrical contact with conductive material on projections of the plurality of projections; and electricallType: ApplicationFiled: January 23, 2014Publication date: May 15, 2014Applicant: Advanced Neuromodulation Systems, Inc.Inventors: John W. Swanson, Kevin Turner, Jerome Boogard
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Publication number: 20120276498Abstract: A sterile, substantially maintenance free disposable dental handpiece is constructed from two shells and a center core, the center core having a flow deflector on one end. The shells are joined around the core with mating protrusions and/or tapered walls to form the body and head of the handpiece. A base is integrally-formed with the center core. The base has conduits that allow entry of light and pressurized air and/or water into the body. The head at the opposite end of the body from the base rotatably mounts an impeller assembly having an impeller shaft. The impeller shaft includes blades driven by the pressurized air. The blades can have cavities to reduce weight.Type: ApplicationFiled: July 2, 2012Publication date: November 1, 2012Inventors: Eli Thomssen, Dirk Schipper, Kevin Turner
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Patent number: 8249884Abstract: A method and system for making a donation to a third party includes storing, via a storage device, a user preference in a user account; receiving, via a receiver, information regarding a purchase transaction at a merchant; accessing, via a processor, the user preference from the user account; dynamically selecting, via the processor, a percentage discount to be allocated to the purchase transaction; donating, via the processor, a monetary value of the percentage discount to the third-party according to the user preference, where the user account is associated with a user, and includes rules for allocating the percentage discount to the third-party.Type: GrantFiled: April 12, 2011Date of Patent: August 21, 2012Assignee: Snoball, Inc.Inventors: Kevin Turner, Omar Besim Hakim, Jeremy Kelley, John Ludlow