Abstract: The present technology provides for altering an authentication technique in response to a detection of a possible attack to which the authentication technique is vulnerable. An authentication provider can receive an authentication request to authenticate to a first resource, where the authentication to the first resource is permitted using a particular authentication technique, includes contextual information associated with the first access device and information identifying the first resource. Based on the contextual information, the authentication provider can determine that the authentication request is subject to an ongoing attack, and determine, an alternative authentication technique that is less vulnerable to the ongoing attack than the particular authentication technique.

Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: A drain assembly capable of being placed inground includes a first panel and a second panel spaced-apart from the first panel, a plurality of supports extending between the first panel and the second panel, a bottom or pipe extending between a bottom portion of the first panel and the second panel, and a cap extending between a top portion of the first panel and the second panel. The first panel may define a plurality of drainage apertures. A related method is also provided.

Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: A system including one or more processors and one or more non-transitory computer-readable media storing computing instructions that, when executed on the one or more processors, perform certain acts. The acts can include receiving information corresponding to a plurality of components in an information technology environment. The acts also can include determining a relationship between a first component of the plurality of components and a second component of the plurality of components based on the information, the relationship based on overlapping information corresponding to the first component and the second component. The acts additionally can include generating a marker for the relationship based on determining a threshold level of correlation between the information corresponding to the first component and the second component. The acts additionally can include auditing the relationship between the first component and the second component to determine if the marker is to be updated.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: This invention provides protein stabilizing compounds, compositions, and methods of use thereof, that include a USP7 Targeting Ligand, a Protein Targeting Ligand, and optionally a Linker for the restoration of a Target Ubiquitinated Protein to treat a disorder mediated by deficiencies of the Target Protein.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: The present disclosure generally relates to receiving a user input corresponding to a rotation of a rotatable input mechanism and in accordance with the user input, adjusting a brightness level of a display screen during a brightening configuration session.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: The present disclosure generally relates to receiving a user input corresponding to a rotation of a rotatable input mechanism and in accordance with the user input, adjusting a brightness level of a display screen during a brightening configuration session.

Abstract: In some embodiments, an electronic device in communication with a display and a touch-sensitive surface displays a user interface, and while displaying the user interface, the electronic device receives touch input comprising a contact detected on the touch-sensitive surface. In some embodiments, in response to receiving the touch input, and in accordance with a determination that the touch input satisfies first criteria, wherein the first criteria include a requirement that the contact continues to be detected in a predefined region of the touch-sensitive surface for longer than a time threshold, the electronic device displays a first indication that further input of a first type detected at the touch sensitive surface will cause the device to display a first system user interface. In some embodiments, in accordance with a determination that the touch input does not satisfy the first criteria, the electronic device forgoes displaying the first indication.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: The present technology provides for altering an authentication technique in response to a detection of a possible attack to which the authentication technique is vulnerable. An authentication provider can receive an authentication request to authenticate to a first resource, where the authentication to the first resource is permitted using a particular authentication technique, includes contextual information associated with the first access device and information identifying the first resource. Based on the contextual information, the authentication provider can determine that the authentication request is subject to an ongoing attack, and determine, an alternative authentication technique that is less vulnerable to the ongoing attack than the particular authentication technique.