Abstract: The present invention relates to apparatus, systems, and methods for analyzing biological samples. The apparatus, systems, and methods can involve using a vacuum source to pull microfluidic volumes through analytical equipment, such as flow cells and the like. Additionally, the invention involves using optical equipment in conjunction with the analytical equipment to analyze samples and control the operation thereof.

Abstract: The present invention relates to apparatus, systems, and methods for analyzing biological samples. The apparatus, systems, and methods can involve using a vacuum source to pull microfluidic volumes through analytical equipment, such as flow cells and the like. Additionally, the invention involves using optical equipment in conjunction with the analytical equipment to analyze samples and control the operation thereof.

Abstract: The present invention discloses thermostable microcapsules comprising a semipermeable membrane, an aqueous core, one or more enzymes in the aqueous core, and a nucleic acid template for an enzyme-mediated reaction in the aqueous core. In one embodiment of the invention, the aqueous core contains one or more polymerases. Microcapsules of the invention can be used in amplification and sequencing reactions. In particular, the microcapsules of the present invention can be used for high-throughput sequencing.

Abstract: The present invention provides methods for preparing micro-capsules, each microcapsule comprising a semipermeable membrane, an aqueous core, one or more enzymes in the aqueous core, and one nucleic acid template in the aqueous core. Microcapsules are prepared by flowing (i) an innermost fluid flow comprising at least one enzyme and at least one nucleic acid template, (ii) a middle fluid flow comprising a semipermeable membrane forming material, and (iii) an outer fluid flow comprising a solution or gas through a multiple sheath flow device. The outer fluid flow entrains the innermost fluid flow and middle fluid flow in the aperture of the multiple sheath flow device. The fluids exit the multiple sheath flow device as a liquid jet resulting in microcapsules.

Abstract: The present invention relates to apparatus, systems, and methods for analyzing biological samples. The apparatus, systems, and methods can involve using a vacuum source to pull microfluidic volumes through analytical equipment, such as flow cells and the like. Additionally, the invention involves using optical equipment in conjunction with the analytical equipment to analyze samples and control the operation thereof.

Abstract: The present invention relates to apparatus, systems, and methods for analyzing biological samples. The apparatus, systems, and methods can involve using a vacuum source to pull microfluidic volumes through analytical equipment, such as flow cells and the like. Additionally, the invention involves using optical equipment in conjunction with the analytical equipment to analyze samples and control the operation thereof.

Abstract: The present invention provides methods for preparing microcapsules, each microcapsule comprising a semipermeable membrane, an aqueous core, one or more enzymes in the aqueous core, and one nucleic acid template in the aqueous core. Microcapsules are prepared by flowing (i) an innermost fluid flow comprising at least one enzyme and at least one nucleic acid template, (ii) a middle fluid flow comprising a semipermeable membrane forming material, and (iii) an outer fluid flow comprising a solution or gas through a multiple sheath flow device. The outer fluid flow entrains the innermost fluid flow and middle fluid flow in the aperture of the multiple sheath flow device. The fluids exit the multiple sheath flow device as a liquid jet resulting in microcapsules.

Abstract: The present invention discloses thermostable microcapsules comprising a semipermeable membrane, an aqueous core, one or more enzymes in the aqueous core, and a nucleic acid template for an enzyme-mediated reaction in the aqueous core. In one embodiment of the invention, the aqueous core contains one or more polymerases. Microcapsules of the invention can be used in amplification and sequencing reactions. In particular, the microcapsules of the present invention can be used for high-throughput sequencing.

Abstract: The present invention relates to devices, systems, and methods for continuous imaging of nucleic acids. In one embodiment, the invention herein generally relates to a device for continuously imaging nucleic acids, the device including a rotating drum in which an exterior surface of the drum includes a plurality of color sensitive pixels.

Abstract: The present invention relates to systems for continuous film electrophoresis and processes for parallel DNA sequencing.

Abstract: The present invention relates to apparatus, systems, and methods for analyzing biological samples. The apparatus, systems, and methods can involve using a vacuum source to pull microfluidic volumes through analytical equipment, such as flow cells and the like. Additionally, the invention involves using optical equipment in conjunction with the analytical equipment to analyze samples and control the operation thereof.

Abstract: The present invention relates to apparatus, systems, and methods for analyzing biological samples. The apparatus, systems, and methods can involve using a vacuum source to pull microfluidic volumes through analytical equipment, such as flow cells and the like. Additionally, the invention involves using optical equipment in conjunction with the analytical equipment to analyze samples and control the operation thereof.

Abstract: The present invention relates to apparatus, systems, and methods for analyzing biological samples. The apparatus, systems, and methods can involve using a vacuum source to pull microfluidic volumes through analytical equipment, such as flow cells and the like. Additionally, the invention involves using optical equipment in conjunction with the analytical equipment to analyze samples and control the operation thereof.

Abstract: Sensors, including ultrasonic components, within a robotic system facilitate the overall operation and efficiency of the robotic system through the detection of objects and surfaces, including the levels of liquids, without contacting the objects or surfaces. The sensors are well-suited for use in connection with microfluidic volumes and biological materials.

Abstract: The present invention relates to apparatus, systems, and methods for analyzing biological samples. The apparatus, systems, and methods can involve using a vacuum source to pull microfluidic volumes through analytical equipment, such as flow cells and the like. Additionally, the invention involves using optical equipment in conjunction with the analytical equipment to analyze samples and control the operation thereof.