Patents by Inventor Kevin Urak

Kevin Urak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid aptamers to treat histone-induced disease states
    Patent number: 11680079
    Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: June 20, 2023
    Assignees: University of Iowa Research Foundation, The United States Government As Represented By The Department of Veteran Affairs
    Inventors: Paloma H. Giangrande, Francis Miller, Kevin Urak
  • Nucleic Acid Aptamers to Treat Histone-Induced Disease States
    Publication number: 20210017217
    Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.
    Type: Application
    Filed: April 13, 2020
    Publication date: January 21, 2021
    Inventors: Paloma H. Giangrande, Francis Miller, Kevin Urak
  • Nucleic acid aptamers to treat histone-induced disease states
    Patent number: 10633410
    Abstract: The present invention relates to methods of using optimized aptamers. In certain embodiments, the present invention provides a method for treating a subject having or being disposed to having a histone-induced injury or disease comprising administering to the subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and (i) a nucleic acid molecule not more than 90 nucleotides in length comprising an aptamer KU1, KU2, KU3, KU4, KU5, KU6, KU&, KU8, or KU9, wherein the aptamer specifically targets extracellular histones, wherein the nucleotides are RNA; or (ii) a conjugate comprising a nucleic acid molecule not more than 90 nucleotides in length comprising an aptamer KU1, KU2, KU3, KU4, KU5, KU6, KU&, KU8, or KU9, wherein the aptamer specifically targets extracellular histones, wherein the nucleotides are RNA, wherein the nucleic acid molecule is linked to a therapeutic molecule.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: April 28, 2020
    Assignee: University of Iowa Research Foundation
    Inventors: Paloma H. Giangrande, Francis Miller, Kevin Urak
  • NUCLEIC ACID APTAMERS TO TREAT HISTONE-INDUCED DISEASE STATES
    Publication number: 20180134746
    Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.
    Type: Application
    Filed: December 22, 2015
    Publication date: May 17, 2018
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Paloma H. Giangrande, Francis Miller, Kevin Urak