Patents by Inventor Kevin Vargo

Kevin Vargo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apparatus and methods for making recombinant protein-stabilized monodisperse microbubbles
    Patent number: 11065348
    Abstract: A microfluidic device for generating microbubbles includes a substrate and a microfluidic channel embedded in the substrate. The microfluidic channel includes a plurality of fluid inlets, at least one bubble formation outlet having a nozzle with an adjustable diameter, and a flow focusing junction in fluid communication with the plurality of fluid inlets and the bubble formation outlet. A method for mass producing monodisperse microbubbles with a microfluidic device includes supplying a flow of dispersed phase fluid into a first fluid inlet of a microfluidic channel, supplying a flow of continuous phase fluid into a second fluid inlet of the microfluidic channel, and adjusting a diameter of a nozzle to obtain a plurality of monodisperse microbubbles having a specified diameter.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: July 20, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Daeyeon Lee, Francesco Angile, Kevin Vargo, Daniel A. Hammer, Chandra M. Sehgal
  • APPARATUS AND METHODS FOR MAKING RECOMBINANT PROTEIN-STABILIZED MONODISPERSE MICROBUBBLES
    Publication number: 20170119911
    Abstract: A microfluidic device for generating mi-crobubbles includes a substrate and a microfluidic channel embedded in the substrate. The microfluidic channel includes a plurality of fluid inlets, at least one bubble formation outlet having a nozzle with an adjustable diameter, and a flow focusing junction in fluid communication with the plurality of fluid inlets and the bubble formation outlet. A method for mass producing monodisperse microbubbles with a microfluidic device includes supplying a flow of dispersed phase fluid into a first fluid inlet of a microfluidic channel, supplying a flow of continuous phase fluid into a second fluid inlet of the microfluidic channel, and adjusting a diameter of a nozzle to obtain a plurality of monodisperse microbubbles having a specified diameter.
    Type: Application
    Filed: June 19, 2015
    Publication date: May 4, 2017
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Daeyeon LEE, Francesco ANGILE, Kevin VARGO, Daniel A. HAMMER, Chandra M. SEHGAL
  • Vesicles and nanostructures from recombinant proteins
    Patent number: 9238010
    Abstract: The present invention includes a composition comprising at least one oleosin-like protein. The present invention also includes a composition comprising a vesicle comprising at least one oleosin-like protein.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: January 19, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Daniel A. Hammer, Kevin Vargo, Ranganath Parthasarathy
  • Novel Vesicles and Nanostructures from Recombinant Proteins
    Publication number: 20140105818
    Abstract: The present invention includes a composition comprising at least one oleosin-like protein. The present invention also includes a composition comprising a vesicle comprising at least one oleosin-like protein.
    Type: Application
    Filed: January 13, 2012
    Publication date: April 17, 2014
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Daniel A. Hammer, Kevin Vargo, Ranganath Parthasarathy