Abstract: In various embodiments, a surgical stapling instrument can include a handle, a shaft extending from the handle, wherein the shaft defines an axis, and a disposable loading unit which is assembled to the shaft in a direction which is transverse to the shaft axis. Such a connection between the disposable loading unit and the shaft can prevent, or at least inhibit, the disposable loading unit from being unintentionally displaced proximally and/or distally relative to the shaft of the surgical instrument. The surgical stapling instrument and/or disposable loading unit can further include a threaded collar and/or detent assembly configured to hold the disposable loading unit in place. In various embodiments, a disposable loading unit can include a lockout feature which can prevent, or at least inhibit, an expended disposable loading unit from being reassembled to the elongated body of the surgical instrument.

Abstract: Provided are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2A, R2B, R3, R4, and R5 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A method for performing an electrosurgical procedure using an electrosurgical instrument including an end effector is disclosed. The method comprises applying a bipolar energy to a target tissue grasped by the end effector in a tissue-feathering segment, applying an energy blend of the bipolar energy and a monopolar energy to the target tissue in a tissue-warming segment and a tissue-sealing segment following the tissue-warming segment, and discontinuing the bipolar energy but continuing to apply the monopolar energy to the target tissue in a tissue-cutting segment following the tissue-sealing segment.