Abstract: Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: A system for the evaluation of respirator materials includes an aerosolized particle source configured to selectively provide aerosolized particles, a mixing chamber including a drying apparatus, a vacuum source configured to control airflow, an airtight respirator chamber for evaluating respirator materials, a processor, and a memory. The airtight respirator chamber includes a first sub-chamber, a second sub-chamber, a first sensor and a second sensor. The memory includes instructions stored thereon, which when executed by the processor cause the system to: obtain the first signal and the second signal; determine an aerosol filtration efficiency based on a difference between the first signal and second signal; compare the aerosol filtration efficiency to a predetermined threshold; and provide an indication whether the aerosol filtration efficiency is above or below the predetermined threshold.

Abstract: A rotor blade system. The rotor blade system includes a rotor and a plurality of blades coupled to the rotor. The plurality of blades are arranged in an airfoil distribution pattern. The airfoil distribution pattern includes one or more baseline blades and one or more intentionally mistuned blades including an intentional mistuning feature.

Abstract: A method of operating an engine is provided. An exhaust valve actuation fault is detected for a first exhaust valve associated with a first cylinder during a first working cycle. In response to the detection of the exhaust valve actuation fault, fueling to at least the first cylinder is cut off. Actuation of the first exhaust valve is attempted in second working cycles that follow the first working cycle, wherein the second working cycles are not fueled. Whether or not the first exhaust valve actuated properly during the second working cycles is determined. Operation of the first cylinder is resumed when it is determined that the first exhaust valve actuated properly. Operation of the first cylinder is not resumed when it is determined that the first exhaust valve did not actuate properly.

Abstract: Provided are small molecule inhibitors of the KRAS(G12D) mutant oncoprotein having the structural formula: and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: A recombinant adeno-associated virus (rAAV) vector comprising an AAVhu68 capsid produced in a production system comprising a nucleotide sequence of SEQ ID NO: 1, or a sequence at least 75% identical thereto which encodes SEQ ID NO:2. The AAVhu68 capsid comprises subpopulations of highly deamidated asparagine residues in asparagine-glycine pairs in the amino acid sequence of SEQ ID NO: 2. Also provided are compositions containing the rAAV and uses thereof. Additionally, rAAV having an engineered AAV capsid comprising at least one subpopulation of vp1 or vp2 proteins having a Val at amino acid position 157 with reference to the AAVhu68 vp1 numbering are provided.

Abstract: Methods and apparatus for processing a substrate are provided herein. For example, a physical vapor deposition processing chamber comprises a chamber body defining a processing volume, a substrate support disposed within the processing volume and comprising a substrate support surface configured to support a substrate, a power supply configured to energize a target for sputtering material toward the substrate, an electromagnet operably coupled to the chamber body and positioned to form electromagnetic filed lines through a sheath above the substrate during sputtering for directing sputtered material toward the substrate, and a controller operably coupled to the physical vapor deposition processing chamber for controlling the electromagnet based on a recipe comprising a pulsing schedule for pulsing the electromagnet during operation to control directionality of ions relative to a feature on the substrate.

Abstract: A memory controller for generating accesses for a memory includes a row hammer logic circuit for providing a sample request. In response to the sample request, the memory controller generates a sample command for dispatch to the memory to cause the memory to capture a current row. In response to a completion of the sample command, the memory controller generates a mitigation command for dispatch to the memory.

Abstract: A method of processing a substrate is disclosed which includes depositing a layer in a processing chamber on a field region, a sidewall region, and a fill region of a feature of the substrate, wherein a hardness of a portion of the layer deposited on the sidewall region is lower than a hardness of a portion of the layer deposited on the field region, and lower than a hardness of a portion of the layer deposited on the fill region.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV) or HMPV. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV or HMPV infection. The invention also relates to methods of treating an RSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: Designs and techniques for manufacturing microelectronic antenna tuners are provided. An example microelectronic antenna system includes a radio frequency integrated circuit comprising a plurality of radio frequency signal ports disposed in a first area, a plurality of tuning devices disposed in a second area of the radio frequency integrated circuit, at least one antenna element disposed on a substrate coupled to the radio frequency integrated circuit, and at least one feedline disposed in the substrate and configured to communicatively couple the at least one antenna element, at least one of the plurality of tuning devices, and one of the plurality of radio frequency signal ports.

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: Systems and methods are described for generating record clusters. The methods comprise receiving a plurality of records from data sources and providing at least a subset of the records to a scoring model that determines scores for various pairings of the records, a score for a given pair of the records representing a probability that the given pair of records contain data elements about the same entity. The method further comprises generating a graph data structure that includes a plurality of nodes, individual nodes representing a different record from the records. The method also comprises assigning a different unique identifier to individual clusters of the final clusters and responding to a request for data regarding a given entity by providing aggregated data elements from those records of the records associated with a cluster of the final clusters having an identifier that represents the given entity.

Abstract: Antigens of Toxoplasma gondii that provide specific and strong delayed type hypersensitivity (DTH) immune response, or which stimulate IFN-? secretion, are used for testing subjects for infection. Any skin testing format may be adapted for testing for the delayed type hypersensitivity, including a patch, a needle, or a prong. Presence of DTH indicates infection. Alternate methods of detecting a T cell response including monitoring IFN-? secretion may be used.

Abstract: Disclosed are support-activators and catalyst compositions comprising the support-activators for polymerizing olefins in which the support-activator includes clay heteroadduct, prepare from a colloidal phyllosilicate such as a colloidal smectite clay, which is chemically-modified with a heterocoagulation agent. By limiting the amount of heterocoagulation reagent relative to the colloidal smectite clay as described herein, the smectite heteroadduct support-activator is a porous and amorphous solid which can be readily isolated from the resulting slurry by a conventional filtration process, and which can activate metallocenes and related catalysts toward olefin polymerization. Related compositions and processes are disclosed.

Abstract: A telepresence robot may include a drive system, a control system, an imaging system, and a mapping module. The mapping module may access a plan view map of an area and tags associated with the area. In various embodiments, each tag may include tag coordinates and tag information, which may include a tag annotation. A tag identification system may identify tags within a predetermined range of the current position and the control system may execute an action based on an identified tag whose tag information comprises a telepresence robot action modifier. The telepresence robot may rotate an upper portion independent from a lower portion. A remote terminal may allow an operator to control the telepresence robot using any combination of control methods, including by selecting a destination in a live video feed, by selecting a destination on a plan view map, or by using a joystick or other peripheral device.

Abstract: Systems and methods for inspection and repair of VSAN object metadata. A user-space indirection layer is maintained to map logical addresses of VSAN objects to physical memory addresses of their metadata. Commands may then be sent from the user space to distributed object manager (DOM) clients, with the physical addresses of metadata of objects to be inspected. DOM owners thus may bypass their own indirection layers to retrieve object metadata directly from received user commands. Retrieved information is then used to reconstruct and repair object metadata. Repaired metadata may be written back to the VSAN by transmitting a write request containing the physical address at which the repaired metadata is to be written. DOM owners may be placed in a specified mode in which received I/O instructions are ignored unless they are designated as being for metadata repair purposes, such as by including a physical address.

Abstract: In some cases, once Fast Reroute (FRR) has taken place (e.g., for MPLS protection), a further FRR is undesirable, and even detrimental. A mechanism to prevent a further FRR, once such a further FRR is determined to be potentially harmful, is described.

Abstract: An electronic device may be provided with an antenna having a resonating element and a light source module mounted to a flexible printed circuit and a metal cowling. The module may emit light through a rear housing wall. The printed circuit may be interposed between the metal cowling and a conductive support plate in the rear housing wall. The printed circuit may include a ground trace coupled to the resonating element. A dimpled pad may couple the ground trace to the support plate. Compressive foam may be used to exert a force against the flexible printed circuit that presses the dimpled pad against the conductive support plate. The ground trace and the dimpled pad may form a return path to ground for the resonating element. The dimpled pad may occupy less height within the device than other structures such as metal springs.