Abstract: An apparatus and method for network channel capacity planning, measuring, and analyzing of WLAN networks are presented. In one embodiment, the method includes importing network and node configuration of an existing physical wireless local area network (WLAN) deployment from WLAN surveying system that captures and analyzes WLAN traffic in order to define a configuration of the existing physical WLAN, simulating a virtual WLAN using the imported network and node configuration as parameters of the simulated WLAN and applying various other configurations not present in the imported network and node configuration as parameters of the simulated WLAN, and analyzing the simulated WLAN to produce throughput statistics of network and nodes of the simulated WLAN.

Abstract: Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.

Abstract: A diagnostic tool and method of diagnosing brain injury and brain injury type (traumatic vs. ischemic) by detecting the level of expression of endothelial monocyte-activating polypeptide II (EMAP-II) and comparing to a control. An increase of EMAP-II indicates the presence of traumatic brain injury and a decrease of EMAP-II indicates the presence of ischemic brain injury.

Abstract: Systems and techniques for displaying detailed information in the context of a condensed enumeration of information. For example, in one aspect, in one aspect, a display includes a visual rendition of a table that systematically arranges condensed information in a collection of rows and columns for reference by a human user. The table includes information characterizing a collection of items. The visual rendition of the table comprises a region that renders additional detail regarding a first item in the collection. The region is disposed in the midst of the visual rendition of the table.

Abstract: Systems, techniques, and machine-readable instructions for coupling simulations with filtering. In one aspect, a method is for coupling simulations with filtering of data. The method includes generating a first visual rendition of a first collection of display data and a second visual rendition of a second collection of display data, receiving user input changing a variable rendered in the second visual rendition, and representing an impact of the change to the variable on the first visual rendition of the first collection of display data. The second collection of display data is a product of filtering the first collection of display data.

Abstract: In large scale proteome applications, protein separation is paramount to observing discrete changes and quantitative evaluation must coincide with qualitative protein identification for effective differential analysis. A four dimensional (4D) platform for resolving and differentially analyzing complex biological samples is presented. The system, collectively termed CAX-PAGE/RPLC-MSMS, combines bi-phasic ion-exchange chromatography (1st dimension) and polyacrylamide gel electrophoresis (2nd dimension) for protein separation, quantification and differential band targeting leading toward subsequent capillary reverse phase liquid chromatography (3rd dimension) and data dependant tandem mass spectrometry (4th dimension) for semi-quantitative and qualitative peptide analysis.

Abstract: The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided.

Abstract: Methods for detecting a cell damage relate to the discovery that proteases are selectively activated in subjects suffering from nervous system damage compared to samples from healthy subjects. Breakdown products reflecting activation of proteases that degrade spectrin are produced. A cell injury is detected by providing a biological sample derived from the subject; detecting in the sample the presence of these breakdown products generated by multiple proteases, and correlating the presence of these breakdown products with the presence or type of cell damage.

Abstract: Novel, sensitive and specific markers for diagnostics and monitoring of liver injuries, including, but not limited to ischemic liver damage, are provided. This includes identification several enzymes of arginine/urea/nitric oxide cycle, sulfuration enzymes and spectrin breakdown related products, among others.

Abstract: The voltage-controlled oscillator (VCO) in a frequency synthesizer using a phase-locked loop (PLL) is calibrated digitally during power up. The VCO has a coarse frequency control and a fine frequency control. The coarse control is a digital phase-locked loop to quantize the broad frequency range into limited number of frequency steps with a clock frequency divided from the VCO frequency, and to hold the phase-locked dc control voltage for the fine control. By limiting the number of frequency steps and clocking at a divided frequency of the VCO, the coarse control is speeded up. The fine control is [connected to the charge pump output as in] a regular PLL. By searching for the optimal control setting, the center frequency of the VCO is trimmed close to the wanted frequency for the PLL to lock. This allows small VCO gain without losing the tolerance of process and temperature variations. As a result, the PLL phase noise performance is improved.

Abstract: Systems and methods for the ex vivo diagnostic analysis of samples of bodily fluids, including exhaled breath and blood. The present invention uses nanostructure-based assemblies in combination with sensor technology to provide an efficient and accurate means for identifying the presence of a target analyte/biomarker in a sample of bodily fluid. In a preferred embodiment, the nanostructure-based assemblies of the present invention include detecting means such as RNA oligonucleotide chains or “apparatus” and releasable surrogate markers such as DMSO.

Abstract: Inhibitors of Nogo Receptor (NgR)-p75 binding are used to reduce NgR-p75 binding mediated axon growth inhibition. Mixtures of NgR and p75 are used in pharmaceutical screens to characterize agents as inhibiting binding of NgR to p75 and promoting axon regeneration.

Abstract: A lamp actuating device includes a number of lamps each having an output terminal, an inverter circuit coupled to the lamps to energize the lamps, a low frequency control unit coupled to the inverter circuit, to set an average value for the level of the effective lamp current at the output terminals of the lamps and to control the inverter circuit, a number of current detecting devices coupled between the lamps and the low frequency control devices to obtain and send the average current value at the output terminals of the lamps to the low frequency control unit. A number of regulating devices are coupled between the lamps and the low frequency control unit, to maintain each lamp at the predetermined average value of the effective current.

Abstract: The invention provides transgenic, non-human animals and transgenic non-human mammalian cells harboring a transgene encoding a TGII (activator of the protein kinase cdk 5) polypeptide. The two neuropathological lesions associated with Alzheimer's disease (AD) are amyloid plaques and neurofibrillary tangles (NFTs), composed predominantly of amyloid ? peptides and hyperphosphorylated tau, respectively. While animal models for plaque formation exist, there is no animal model that recapitulates the formation of NFTs. This invention provides transgenic mice that overexpress human TGII, an activator of cdk5, resulting in tau that is hyperphosphorylated at AD-relevant epitopes. Deposition of tau is detected in the amygdala, thalamus and cortex. Increased phosphorylated neurofilament, silver-positive neurons and neuronal death are also observed in these regions. We conclude that the overexpression of TGII, an activator of cdk5, is sufficient to produce hyperphosphorylation of tau and neuronal death.

Abstract: The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.

Abstract: The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.

Abstract: Two reference signals are applied to an RC calibration circuit, which utilizes programmable resistors and switched capacitor resistors in parallel at the inputs of a differential amplifier with feedback capacitors, for the first cycle and then the two reference signals are swapped for the successive cycle. The circuit inherent DC offset is cancelled by these two successive cycles. The time duration when the difference of the differential amplifier outputs in the calibration circuit starts to reverse ramping direction and the time when the difference crosses zero is counted in terms of reference clock cycles by a binary counter. The binary count is used to select the capacitance of the capacitor arrays in an RC filter for time constant calibration. This calibration circuit provides the flexibility for various reference clock rates by adjusting the programmable resistors.

Abstract: The DCOC block is used in ZIF BB to form HPF function to cancel dc offset with a penalty of small silicon area and low power consumption. It is a LPF plus a voltage to current conversion (VIC) resistor, and can hook up with any BB opamp used in signal path, to form a feedback loop, with or without signal gain stages in the loop. The BB opamp is used as a summing point. The summing method is input current summing. The cutoff frequency of the HPF function is thus defined by the integrator, the VIC resistor, and the feedback resistor in the summing opamp. The presence of the VIC resistor can drastically reduce the integrator capacitor and resistor values and thus save silicon area or improve receiver performance.

Abstract: A lamp actuating device includes a number of lamps each having an output terminal, an inverter circuit coupled to the lamps to convert electric power and to energize the lamps, a low frequency control unit coupled to the inverter circuit, to set an average current value at the output terminals of the lamps and to control the inverter circuit, a number of current detecting units coupled between the lamps and the low frequency control unit to obtain and send the average current value at the output terminals of the lamps to the low frequency control unit. A number of regulating devices are coupled between the lamps and the low frequency control unit respectively, to control electric power through the lamps, and to maintain each of the lamps at the average current value.