Abstract: The present invention provides stabilized cream formulations of oxymetazoline and uses thereof. The present invention also provides a method of treating facial erythema associated with rosacea in a patient in need of such treatment, comprising topically administering once or twice daily to the site of erythema on the face of the patient a pharmaceutical composition comprising 0.5%, 1.0% or 1.5% oxymetazoline or a pharmaceutically acceptable salt thereof as the sole active ingredient.

Abstract: An improved liquid vaporization and conditioning system, and associated method, for efficiently vaporizing a liquid sample for accurately determining the constituent components thereof providing enhanced flow rate, pressure and thermal control, the improvement including a combination of a resistance temperature detector, a sweeping bend to, an in-line thermal break, a flow buffering input manifold, enhanced multi-path heater vaporizer construction with four heater units, a vaporizer output mixing manifold and control elements providing a capability for partial shutdown in the event of compromised heating or flow anomalies without risk of flow loss/volume capacity beyond a permissible threshold and an improved, modular heat vaporizer enclosure.

Abstract: A multi-stage pressure regulation system, device and associated methodology for reducing the pressure of gas passing through a gas sample conditioning system. The device and method allow for automatic and/or manual configuration settings for regulating different types of gas having different profiles while still avoiding dew point dropout thereby ensuring accurate sample analysis at a downstream analyzer. The pressure regulating device includes a housing having a core, a vapor sample input port, a plurality of openings on an upper surface, a plurality of pressure regulating valves configured to reduce the pressure of a vapor sample, and an assembly having a base and substantially central stem orthogonal to the base and extending axially therefrom, the stem being disposed within the core.

Abstract: An improved liquid vaporization and conditioning system, and associated method, for efficiently vaporizing a liquid sample for accurately determining the constituent components thereof providing enhanced flow rate, pressure and thermal control, the improvement including a combination of a resistance temperature detector, a sweeping bend to, an in-line thermal break, a flow buffering input manifold, enhanced multi-path heater vaporizer construction with four heater units, a vaporizer output mixing manifold and control elements providing a capability for partial shutdown in the event of compromised heating or flow anomalies without risk of flow loss/volume capacity beyond a permissible threshold and an improved, modular heat vaporizer enclosure.

Abstract: A multi-stage pressure regulation system, device and associated methodology for reducing the pressure of gas passing through a gas sample conditioning system. The device and method allow for automatic and/or manual configuration settings for regulating different types of gas having different profiles while still avoiding dew point dropout thereby ensuring accurate sample analysis at a downstream analyzer. The pressure regulating device includes a housing having a core, a vapor sample input port, a plurality of openings on an upper surface, a plurality of pressure regulating valves configured to reduce the pressure of a vapor sample, and an assembly having a base and substantially central stem orthogonal to the base and extending axially therefrom, the stem being disposed within the core.

Abstract: A system and method for substantially coincidental sample takeoff flow rate verification which detects unstable flow conditions in a pipeline, terminates fluid sample analysis during flow instability, and resumes sample takeoff when a steady flow state is re-established.

Abstract: A vaporizer device and associated methodology for providing accurate sampling through substantially efficient, complete and uniform single pass vaporization of a liquid sample by avoiding liquid pre-vaporization and downtime attributable to system damage from incomplete vaporization, particularly in the distribution, transportation, and custody transfer of natural gas. The vaporizer device includes at least one input port for receiving a liquid sample, a channel for directing the liquid to a vaporizer core and a heating assembly within the vaporizer core configured to flash vaporize the liquid sample. The vaporized sample can then be passed to an outlet for sample analysis.

Abstract: The present invention provides stabilized cream formulations of oxymetazoline and uses thereof. The present invention also provides a method of treating facial erythema associated with rosacea in a patient in need of such treatment, comprising topically administering once or twice daily to the site of erythema on the face of the patient a pharmaceutical composition comprising 0.5%, 1.0% or 1.5% oxymetazoline or a pharmaceutically acceptable salt thereof as the sole active ingredient.

Abstract: A multi-component in-line thermal break including concentrical arranges, an outer thermally insulating body, an elongated axial insert incorporating integrated pipe fittings, and a thermally non-conductive fluid channel tube set within the elongated axial insert.

Abstract: A cryogenic liquid sampling system including a chamber having affixed therein a sample pump to proportionally pull a cryogenic liquid sample from an external source to a constant pressure piston accumulator and an enclosure. The enclosure includes a supply port to receive an input stream of a gas, an input port connected to the chamber via a vacuum line, a sample pump port connected to the chamber via a pump line and configured to feed therethrough gas received at the supply port to the sample pump, a vacuum device connected to the input port and configured to generate a vacuum within the chamber by pulling air from the vacuum line, and processing circuitry to control the vacuum device and the sample pump to perform transfer of a cryogenic liquid sample from the external source to an external device.

Abstract: A method includes forming one or more cores, wherein each of the one or more cores has a cross section corresponding to a conductor to be subsequently formed, forming an insulator around the one or more cores, removing the one or more cores to expose one or more recesses within the insulator, and forming one or more conductors in at least one of the one or more recesses of the insulator such that the cross sections of the one or more conductors conform to an interior surface of the one or more recesses in the insulator.

Abstract: A multi-stage pressure regulation system, device and associated methodology for reducing the pressure of gas passing through a gas sample conditioning system. The device and method allow for automatic and/or manual configuration settings for regulating different types of gas having different profiles while still avoiding dew point dropout thereby ensuring accurate sample analysis at a downstream analyzer. The pressure regulating device includes a housing having a core, a vapor sample input port, a plurality of openings on an upper surface, a plurality of pressure regulating valves configured to reduce the pressure of a vapor sample, and an assembly having a base and substantially central stem orthogonal to the base and extending axially therefrom, the stem being disposed within the core.

Abstract: A multi-stage pressure regulation system, device and associated methodology for reducing the pressure of gas passing through a gas sample conditioning system. The device and method allow for automatic and/or manual configuration settings for regulating different types of gas having different profiles while still avoiding dew point dropout thereby ensuring accurate sample analysis at a downstream analyzer. The pressure regulating device includes a housing having a core, a vapor sample input port, a plurality of openings on an upper surface, a plurality of pressure regulating valves configured to reduce the pressure of a vapor sample, and an assembly having a base and substantially central stem orthogonal to the base and extending axially therefrom, the stem being disposed within the core.

Abstract: The present invention provides stabilized cream formulations of oxymetazoline and uses thereof. The present invention also provides a method of treating facial erythema associated with rosacea in a patient in need of such treatment, comprising topically administering once or twice daily to the site of erythema on the face of the patient a pharmaceutical composition comprising 0.5%, 1.0% or 1.5% oxymetazoline or a pharmaceutically acceptable salt thereof as the sole active ingredient.

Abstract: A vaporizer device and associated methodology for providing accurate sampling through substantially efficient, complete and uniform single pass vaporization of a liquid sample by avoiding liquid pre-vaporization and downtime attributable to system damage from incomplete vaporization, particularly in the distribution, transportation, and custody transfer of natural gas. The vaporizer device includes at least one input port for receiving a liquid sample, a channel for directing the liquid to a vaporizer core and a heating assembly within the vaporizer core configured to flash vaporize the liquid sample. The vaporized sample can then be passed to an outlet for sample analysis.

Abstract: A multi-stage pressure regulation system, device and associated methodology for reducing the pressure of gas passing through a gas sample conditioning system. The device and method allow for automatic and/or manual configuration settings for regulating different types of gas having different profiles while still avoiding dew point dropout thereby ensuring accurate sample analysis at a downstream analyzer. The pressure regulating device includes a housing having a core, a vapor sample input port, a plurality of openings on an upper surface, a plurality of pressure regulating valves configured to reduce the pressure of a vapor sample, and an assembly having a base and substantially central stem orthogonal to the base and extending axially therefrom, the stem being disposed within the core.

Abstract: A cryogenic liquid sampling system including a chamber having affixed therein a sample pump to pull a cryogenic liquid sample from an external source and an enclosure. The enclosure includes a supply port to receive an input stream of a gas, an input port connected to the chamber via a vacuum line, a sample pump port connected to the chamber via a pump line and configured to feed therethrough gas received at the supply port to the sample pump, a vacuum device connected to the input port and configured to generate a vacuum within the chamber by pulling air from the vacuum line, and processing circuitry to control the vacuum device and the sample pump to perform transfer of a cryogenic liquid sample from the external source to an external device.

Abstract: A vaporizer device and associated methodology for providing accurate sampling through substantially efficient, complete and uniform single pass vaporization of a liquid sample by avoiding liquid pre-vaporization and downtime attributable to system damage from incomplete vaporization, particularly in the distribution, transportation, and custody transfer of natural gas. The vaporizer device includes at least one input port for receiving a liquid sample, a channel for directing the liquid to a vaporizer core and a heating assembly within the vaporizer core configured to flash vaporize the liquid sample. The vaporized sample can then be passed to an outlet for sample analysis.

Abstract: A method includes forming one or more cores, wherein each of the one or more cores has a cross section corresponding to a conductor to be subsequently formed, forming an insulator around the one or more cores, removing the one or more cores to expose one or more recesses within the insulator, and forming one or more conductors in at least one of the one or more recesses of the insulator such that the cross sections of the one or more conductors conform to an interior surface of the one or more recesses in the insulator.