Abstract: A system for ab-interno trabeculotomy is provided. The system comprises an inserter device for inserting an excising device into the anterior chamber of a human eye. The inserter features a tubular structure, a tip for excising the trabecular meshwork, and a cannula for injecting fluids into the anterior chamber. The inserter optionally features roller mechanisms for advancing and retracting an excising device. The system also features a trabecular excision device having a rough surface for excising the inner wall of Schlemm's canal. The rough surface may comprise different shapes such as porcupines, cones, fins or the like. The system may also feature a custom eyelid speculum for supporting an endoscope that is movable with respect to the eye and pivotally movable along an incision point in the eye.

Abstract: A system and method for diagnosing and treating glaucoma is presented. The system imparts pressure on the anterior chamber of a eye using a coupling mechanism, while capturing three-dimensional imagery of the eye using optical coherence tomography angiography. Applying pressure in various areas of the eye, imparts changes that can help detect parts of the eye, or diagnose certain disorders related to the drainage of aqueous humor. A controller coupled to the optical coherence tomography angiography scanner may be used to guide a laser for excision of the trabecular meshwork for enhancing aqueous humor drainage thus lowering intraocular pressure and preventing glaucoma.

Abstract: A system and method for diagnosing and treating glaucoma is presented. The system imparts pressure on the anterior chamber of a eye using a coupling mechanism, while capturing three-dimensional imagery of the eye using optical coherence tomography angiography. Applying pressure in various areas of the eye, imparts changes that can help detect parts of the eye, or diagnose certain disorders related to the drainage of aqueous humor. A controller coupled to the optical coherence tomography angiography scanner may be used to guide a laser for excision of the trabecular meshwork for enhancing aqueous humor drainage thus lowering intraocular pressure and preventing glaucoma.

Abstract: A hazardous materials protective garment for protecting the wearer while maintaining the sterile field, and further offering the wearer the ability to directly access and interface with technological equipment being operated during a surgical procedure. The hazardous materials protective garment comprising one or more functional windows positioned on the garment to allow the wearer to interface with a device attached to the wearer underneath the garment, for example a device attached to the wearer's arm and/or chest. The windows disposed in the garment are sized and adapted to accommodate a variety of devices including cameras for POV filming and/or recording, as well as control displays for remotely located technological equipment.

Abstract: Devices and methods for the ab interno delivery of two or more fluid compositions into Schlemm's canal through a single insertion point in the eye with minimal trauma. The hand-held delivery device includes a handle coupled to an elongated shaft that terminates in a self-trephinating tip through which one or more cannulae are slidably disposed and can be extended or retracted therethrough. The handle further defines a chamber for receiving one or more cartridges each containing at least one fluid composition. Each cartridge is fluidly connected to a respective cannula such that sequential actuation of each cartridge causes dispensation of the fluid compositions at the site for delivery without having to repeatedly enter the target site multiple times. Ab interno methods for localized delivery of a fluid composition into Schlemm's canal are further described.