Abstract: The present disclosure relates to extracellular vesicles comprising one or more antigens from a coronavirus (e.g., SARS-CoV-1 or SARS-CoV-2) and optionally an adjuvant. Also provided herein are methods for producing the EVs and methods for using the EVs to treat and/or prevent diseases or disorders, e.g., infectious diseases.

Abstract: Methods of forming devices comprise forming a dielectric layer on a substrate, the dielectric layer comprising at least one feature defining a gap including sidewalls and a bottom. A self-assembled monolayer (SAM) is formed on the bottom of the gap, and a barrier layer is formed on the SAM before selectively depositing a metal liner on the barrier layer. The SAM is removed after selectively depositing the metal liner on the barrier layer.

Abstract: Integrated circuit structures having internal spacers for 2D channel materials, and methods of fabricating integrated circuit structures having internal spacers for 2D channel materials, are described. For example, an integrated circuit structure includes a stack of two-dimensional (2D) material nanowires. A gate structure is vertically around the stack of 2D material nanowires. Internal gate spacers are between vertically adjacent ones of the stack of 2D material nanowires and laterally adjacent to the gate structure. The 2D material nanowires are recessed relative to the internal gate spacers. Conductive contact structures are at corresponding ends of the stack of 2D material nanowires, the conductive contact structures adjacent to the internal gate spacers and vertically overlapping with the internal gate spacers.

Abstract: The present disclosure relates to compounds that are Syk inhibitors or pharmaceutically acceptable salts or co-crystals thereof, and pharmaceutical compositions thereof, and to their use in the treatment of various disease states, including cancer and inflammatory conditions.

Abstract: The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.

Abstract: Provided are compounds of Formula (I): wherein R1, R2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.

Abstract: A system described herein may maintain one or more smart contracts on a distributed ledger. The system may receive a request, associated with a User Equipment (“UE”), for access to a particular network (e.g., a private network), identify one or more attributes of the UE, and select a particular smart contract based on the attributes of the UE. The system may execute the selected particular smart contract, which may include performing operations, indicated by the particular smart contract, using the one or more attributes of the UE as inputs. Executing the particular smart contract may further include identifying outputs that result from performing the particular set of operations using the attributes of the UE as inputs, such as a network access policy for the UE. The system may output a response to the request, indicating the network access policy determined based on executing the particular smart contract.

Abstract: A method includes monitoring content inline between any of users, enterprises, and the Internet by a cloud-based system; analyzing the content with a trained machine learning model to provide an initial classification of benign or malicious; determining an uncertainty associated with the initial classification; and one of allowing the content, blocking the content, and sandboxing the content, based on the initial classification and the uncertainty. The uncertainty is used to minimize latency for user experience while avoiding incorrect classifications, in the inline monitoring.

Abstract: A linear accelerator is provided. The linear accelerator includes a plurality of cells. Each cell includes an outer ring comprising a first material; an inner ring, comprising a second material, and at least one end plate in physical contact with the outer ring and the inner ring and having beam aperture therethrough. The first material is substantially electrically conductive and the second material is substantially not electrically conductive. The inner ring is centered within the outer ring. The beam aperture of each cell of the plurality of cells are aligned to define a beam path.

Abstract: The invention relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting the SCAP gene, as well as methods of inhibiting epression of a SCAP gene and methods of treating subjects having a SCAP-associated disorder, such as nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH), using such dsRNAi agents and compositions.

Abstract: Methods of forming devices comprise forming a dielectric layer on a substrate, the dielectric layer comprising at least one feature defining a gap including sidewalls and a bottom. A self-assembled monolayer (SAM) is formed on the bottom of the gap, and a barrier layer is formed on the SAM before selectively depositing a metal liner on the barrier layer. The SAM is removed after selectively depositing the metal liner on the barrier layer.

Abstract: An unmanned aerial vehicle (UAV) that includes: a chassis; a plurality of arms that extend outwardly from the chassis; a plurality of propeller assemblies that are supported by the plurality of arms; a canopy that is connected to the chassis so as to provide an outer cover for the UAV that is configured to protect internal components thereof; a frame that is supported by the canopy such that the frame is isolated from the chassis; and a plurality of image capture assemblies that are supported by the frame such that the frame separates the plurality of image capture assemblies from the chassis and the canopy so as to inhibit relative movement between the plurality of image capture assemblies during operation of the UAV.

Abstract: An unmanned aerial vehicle (UAV) that includes: a chassis; a plurality of arms that extend outwardly from the chassis; a plurality of propeller assemblies that are supported by the plurality of arms; a canopy that is connected to the chassis so as to provide an outer cover for the UAV that is configured to protect internal components thereof; a frame that is supported by the canopy such that the frame is isolated from the chassis; and a plurality of image capture assemblies that are supported by the frame such that the frame separates the plurality of image capture assemblies from the chassis and the canopy so as to inhibit relative movement between the plurality of image capture assemblies during operation of the UAV.

Abstract: A source site includes a controller, a set of source worker nodes, and a message queue connected between the controller and source worker nodes. The message queue receives messages and stores the messages for retrieval. A destination site includes a set of destination worker nodes. Tasks are generated to replicate changes to objects at the source site to the destination site. The controller pushes messages corresponding to the tasks onto the message queue. A source worker node retrieves a message corresponding to a task from the message queue for processing in conjunction with a destination worker node. The message is indicated as having been retrieved from the message queue.

Abstract: A system described herein may determine that a first measure of likelihood of demand for a particular service from a first set of edge computing devices exceeds a first threshold, and may instruct the first set of edge computing devices to provision resources to provide the particular service. The system may subsequently determine that a second measure of likelihood of demand for the particular service from a second set of edge computing devices exceeds a second threshold, the second set of edge computing devices being a subset of the first set of edge computing devices, and may initiate a service state synchronization operation with respect to the second set of edge computing devices. The system may select a particular edge computing device, of the second set of edge computing devices, to provide the particular service to a User Equipment (“UE”).

Abstract: One or more computing devices, systems, and/or methods for dynamic resource slice allocation are provided. A bidding engine dynamically tracks available network slices and available edge computing resources to generate a current list of resource slices corresponding to combinations of available network slices and available edge computing resources. A bidding auction is conducted for the current list of resource slices. A user equipment device is determined to be a winner of the bidding auction for a resource slice based upon a bidding request from the user equipment device. In this way, the user equipment device is provide with access to the resource slice based upon a determination that the user equipment device won the bidding auction.

Abstract: A system described herein may identify a particular service provided by a first Edge Computing (“EC”) device to a particular User Equipment (“UE”), and may monitor performance information associated with the first EC device and/or a second EC device. The system may determine, based on the monitoring, that the second EC device should provide the service to the particular UE in lieu of the first EC device; and may accordingly cause the service to be provided to the particular UE by the second EC device in lieu of the first EC device. The system may notify the first EC device that the second EC device has been selected to provide the service to the particular UE in lieu of the first EC device, and/or may notify the second EC device that the second EC device has been selected to provide the service to the particular UE.

Abstract: A system described herein may provide a technique for receiving a communication session request associated with a particular User Equipment (“UE”). The system may identify locator information associated with an edge discovery system associated with a network that includes a plurality of edge devices, wherein the edge discovery system receives service requests associated with one or more UEs and provides an indication of a respective edge device of the plurality of edge device in response to respective service requests. The system may output, in response to the communication session request, the locator information associated with the edge discovery system, wherein the particular UE communicates with the edge discovery system using the locator information to output a particular service request and receive, from the edge discovery system, an indication of a particular edge device of the plurality of edge devices in response to the particular service request.

Abstract: A system described herein may maintain one or more smart contracts on a distributed ledger. The system may receive a request, associated with a User Equipment (“UE”), for access to a particular network (e.g., a private network), identify one or more attributes of the UE, and select a particular smart contract based on the attributes of the UE. The system may execute the selected particular smart contract, which may include performing operations, indicated by the particular smart contract, using the one or more attributes of the UE as inputs. Executing the particular smart contract may further include identifying outputs that result from performing the particular set of operations using the attributes of the UE as inputs, such as a network access policy for the UE. The system may output a response to the request, indicating the network access policy determined based on executing the particular smart contract.

Abstract: A system described herein may provide a technique for selectively granting or revoking/denying access to applications, services, data, etc. to a User Equipment (“UE”) based on location-based policies and a network-determined location of the UE. The network-determined location may be determined by elements of a wireless network, such as a Mobility Management Entity (“MME”), Access and Mobility Management Function (“AMF”), or other suitable element.