Patents by Inventor Kevin Yu Wang

Kevin Yu Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONJUGATES CONTAINING HYDROPHILIC SPACER LINKERS
    Publication number: 20210024581
    Abstract: Described herein are compositions and methods for use in targeted drug delivery using cell receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in imaging, diagnosing, and/or treating diseases and disease states caused by pathogenic cell populations.
    Type: Application
    Filed: July 2, 2020
    Publication date: January 28, 2021
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Hari Krishna R. Santhapuram, Paul Joseph Kleindl, Kevin Yu Wang, Fei You
  • PBD CONJUGATES FOR TREATING DISEASES
    Publication number: 20200323991
    Abstract: The present disclosure relates to pyrrolobenzodiazepine (PBD) prodrugs and conjugates thereof. The present disclosure also relates to pharmaceutical compositions of the conjugates described herein, methods of making and methods of using the same.
    Type: Application
    Filed: March 29, 2017
    Publication date: October 15, 2020
    Inventors: Iontcho Radoslavov VLAHOV, Christopher Paul LEAMON, Longwu QI, Ning ZOU, Kevin Yu WANG, Albert E. FELTEN, Garth L. PARHAM, Fei YOU, Hari Krishna R. SANTHAPURAM, Spencer J. HAHN, Joseph Anand REDDY, Yingjuan J. LU, Leroy W. WHEELER, II
  • CONJUGATES FOR TREATING DISEASES
    Publication number: 20200289659
    Abstract: The present disclosure relates to pyrrolobenzodiazepine (PBD) prodrugs and conjugates thereof. The present disclosure also relates to pharmaceutical compositions of the conjugates described herein, methods of making and methods of using the same.
    Type: Application
    Filed: March 20, 2020
    Publication date: September 17, 2020
    Inventors: Iontcho Radoslavov Vlahov, Christopher Paul Leamon, Longwu QI, Yingcai Wang, Kevin Yu Wang, Ning Zou, Albert E. Felten
  • Conjugates containing hydrophilic spacer linkers
    Patent number: 10738086
    Abstract: Described herein are compositions and methods for use in targeted drug delivery using cell-surface receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: August 11, 2020
    Assignee: Endocyte Inc.
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Hari Krishna R. Santhapuram, Paul Joseph Kleindl, Kevin Yu Wang, Fei You
  • VITAMIN RECEPTOR DRUG DELIVERY CONJUGATES FOR TREATING INFLAMMATION
    Publication number: 20200155555
    Abstract: Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells.
    Type: Application
    Filed: November 13, 2019
    Publication date: May 21, 2020
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Yingjuan June Lu, Kevin Yu Wang, Fei You, Paul Joseph Kleindl, Hari Krishna R. Santhapuram
  • Conjugates for treating diseases
    Patent number: 10624972
    Abstract: The present disclosure relates to pyrrolobenzodiazepine (PBD) prodrugs and conjugates thereof. The present disclosure also relates to pharmaceutical compositions of the conjugates described herein, methods of making and methods of using the same.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: April 21, 2020
    Assignee: Endocyte, Inc.
    Inventors: Iontcho Radoslavov Vlahov, Christopher Paul Leamon, Longwu Qi, Yingcai Wang, Kevin Yu Wang, Ning Zou, Albert E. Felten
  • FOLATE CONJUGATE FOR USE IN TARGETING TUMOR ASSOCIATED MACROPHAGES
    Publication number: 20200038514
    Abstract: Methods are provided for treating cancers using a conjugate herein described as Conjugate 5, or a pharmaceutically acceptable salt thereof. Methods for treating cancers using Conjugate 5, or a pharmaceutically acceptable salt thereof, to target tumor associated macrophages are also described.
    Type: Application
    Filed: September 14, 2017
    Publication date: February 6, 2020
    Inventors: Iontcho Radoslavov VLAHOV, Christopher Paul LEAMON, Longwu QI, Ning ZOU, Kevin Yu WANG, Albert E. FELTEN, Garth L. PARHAM, Fei YOU, Hari Krishna R. SANTHAPURAM, Spencer J. HAHN, Joseph Anand REDDY, Yingjuan J. LU, Leroy W. WHEELER, II
  • Vitamin receptor drug delivery conjugates for treating inflammation
    Patent number: 10500204
    Abstract: Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: December 10, 2019
    Assignee: Endocyte, Inc.
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Yingjuan June Lu, Kevin Yu Wang, Fei You, Paul Joseph Kleindl, Hari Krishna R. Santhapuram
  • CONJUGATES FOR TREATING DISEASES
    Publication number: 20180228914
    Abstract: The present disclosure relates to pyrrolobenzodiazepine (PBD) prodrugs and conjugates thereof. The present disclosure also relates to pharmaceutical compositions of the conjugates described herein, methods of making and methods of using the same.
    Type: Application
    Filed: March 13, 2015
    Publication date: August 16, 2018
    Inventors: Iontcho Radoslavov VLAHOV, Christopher Paul LEAMON, Longwu QI, Yingcai WANG, Kevin Yu WANG, Ning ZOU, Albert E. FELTEN
  • VITAMIN RECEPTOR DRUG DELIVERY CONJUGATES FOR TREATING INFLAMMATION
    Publication number: 20180221372
    Abstract: Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells.
    Type: Application
    Filed: November 13, 2017
    Publication date: August 9, 2018
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Yingjuan June Lu, Kevin Yu Wang, Fei You, Paul Joseph Kleindl, Hari Krishna R. Santhapuram
  • Vitamin receptor drug delivery conjugates for treating inflammation
    Patent number: 9877965
    Abstract: Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: January 30, 2018
    Assignee: Endocyte, Inc.
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Yingjuan June Lu, Kevin Yu Wang, Fei Yu, Paul Joseph Kleindl, Hari Krishna R. Santhapuram
  • BINDING LIGAND LINKED DRUG DELIVERY CONJUGATES OF TUBULYSINS
    Publication number: 20170327537
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations. The compounds described herein include conjugates of tubulysins and vitamin receptor binding ligands. The conjugates also include a releasable bivalent linker.
    Type: Application
    Filed: January 30, 2017
    Publication date: November 16, 2017
    Inventors: Iontcho R. VLAHOV, Christopher P. LEAMON, Kevin Yu WANG
  • VITAMIN RECEPTOR DRUG DELIVERY CONJUGATES FOR TREATING INFLAMMATION
    Publication number: 20170319585
    Abstract: Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells.
    Type: Application
    Filed: March 27, 2015
    Publication date: November 9, 2017
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Yingjuan June Lu, Kevin Yu Wang, Fei Yu, Paul Joseph Kleindl, Hari Krishna R. Santhapuram
  • Tubulysins and processes for preparing
    Patent number: 9745341
    Abstract: Processes are described for the preparation of tubulysins. The processes are useful for preparing predetermined mixtures of tubulysins, preparing single tubulysins from mixtures of tubulysins, and for converting one tubulysin into a different tubulysin. The tubulysins described herein are useful in treating diseases and disease states that include pathogenic cell populations.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: August 29, 2017
    Assignee: Endocyte, Inc.
    Inventors: Iontcho Radoslavov Vlahov, Christopher Paul Leamon, Kevin Yu Wang
  • Conjugates Containing Hydrophilic Spacer Linkers
    Publication number: 20170151340
    Abstract: Described herein are compositions and methods for use in targeted drug delivery using cell receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in imaging, diagnosing, and/or treating diseases and disease states caused by pathogenic cell populations.
    Type: Application
    Filed: February 13, 2017
    Publication date: June 1, 2017
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Hari Krishna R. Santhapuram, Paul Joseph Kleindl, Kevin Yu Wang, Fei You
  • Processes for preparing tubulysins
    Patent number: 9499849
    Abstract: Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: November 22, 2016
    Assignee: Endocyte, Inc.
    Inventors: Iontcho Radoslavov Vlahov, Michael Groaning, Paul Joseph Kleindl, Hari Krishna R. Santhapuram, Fei You, Kevin Yu Wang, Le-Cun Xu, Katheryn Marie Stanford, Allen Ritter, Christopher Paul Leamon
  • PROCESSES FOR PREPARING TUBULYSINS
    Publication number: 20160177363
    Abstract: Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.
    Type: Application
    Filed: February 26, 2016
    Publication date: June 23, 2016
    Inventors: Iontcho Radoslavov VLAHOV, Michael GROANING, Paul Joseph KLEINDL, Hari Krishna R. SANTHAPURAM, Fei YOU, Kevin Yu WANG, Le-Cun XU, Katheryn Marie STANFORD, Allen RITTER, Christopher Paul LEAMON
  • TUBULYSINS AND PROCESSES FOR PREPARING
    Publication number: 20160108085
    Abstract: Processes are described for the preparation of tubulysins. The processes are useful for preparing predetermined mixtures of tubulysins, preparing single tubulysins from mixtures of tubulysins, and for converting one tubulysin into a different tubulysin. The tubulysins described herein are useful in treating diseases and disease states that include pathogenic cell populations.
    Type: Application
    Filed: October 23, 2015
    Publication date: April 21, 2016
    Inventors: Iontcho Radoslavov Vlahov, Christopher Paul Leamon, Kevin Yu Wang
  • Processes for preparing tubulysins
    Patent number: 9273091
    Abstract: Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: March 1, 2016
    Assignee: Endocyte, Inc.
    Inventors: Iontcho Radoslavov Vlahov, Michael Groaning, Paul Joseph Kleindl, Hari Krishna R. Santhapuram, Fei You, Kevin Yu Wang, Le-Cun Xu, Katheryn Marie Stanford, Allen Ritter, Christopher Paul Leamon
  • PROCESSES FOR PREPARING TUBULYSINS
    Publication number: 20150225447
    Abstract: Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.
    Type: Application
    Filed: October 20, 2014
    Publication date: August 13, 2015
    Applicant: ENDOCYTE, INC.
    Inventors: Iontcho Radoslavov VLAHOV, Michael GROANING, Paul Joseph KLEINDL, Hari Krishna R. SANTHAPURAM, Fei YOU, Kevin Yu WANG, Le-Cun XU, Katheryn Marie STANFORD, Allen RITTER, Christopher Paul LEAMON