Patents by Inventor Kevon Ray Shuler

Kevon Ray Shuler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridine matrix metalloproteinase inhibitors
    Patent number: 6881743
    Abstract: Selective MMP-13 inhibitors are pyridine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 independently are hydrogen, halo, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, NO2, NR4R5, CN, or CF3, E is independently O or S; A and B independently are OR4 or NR4R5; R4 and R5 independently are H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)n aryl, (CH2)n cycloalkyl, (CH2)n heteroaryl, or R4 and R5 when taken together with the nitrogen to which they are attached complete a 3- to 8-membered ring containing carbon atoms and optionally containing a heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted, n is an integer of from 0 to 6.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: April 19, 2005
    Assignee: Warner-Lambert Company
    Inventors: Nicole Chantel Barvian, David Thomas Connor, Patrick Michael O'Brien, Daniel Fred Ortwine, William Chester Patt, Kevon Ray Shuler, Michael William Wilson
  • Inhibitors of protein farnesyl transferase
    Patent number: 6737410
    Abstract: The present invention provides compounds having the structure represented by Formula I: and methods of treating cancer, restenosis, atherosclerosis, or psoriasis or preventing restenosis, and a pharmaceutical composition comprising a compound of Formula I and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: May 18, 2004
    Assignee: Warner-Lambert Company
    Inventors: Annette Marian Doherty, Daniele Marie Leonard, Dennis Joseph McNamara, Kevon Ray Shuler
  • Sulfonamide matrix metalloproteinase inhibitors
    Patent number: 6559142
    Abstract: Matrix metalloproteinase inhibitors are tricyclic substituted cyclic sulfonamides of the formula or a pharmaceutically acceptable salt thereof wherein R1 and R2 include hydrogen, alkyl, and substituted alkyl; R3 and R4 include hydrogen, halo, and alkyl; X is OH or NHOH, V is O, S, SO2, NR5, or CH2, R5 is a hydrogen or alkyl, and Z is (CH2)n, wherein n is an integer from 0 to 2.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: May 6, 2003
    Assignee: Warner-Lambert Company
    Inventors: Patrick Michael O'Brien, William Chester Patt, Joseph Armand Picard, Kevon Ray Shuler, Drago Robert Sliskovic
  • Fused pyrimidinone matrix metalloproteinase inhibitors
    Publication number: 20030004172
    Abstract: Selective MMP-13 inhibitors are fused pyrimidinones of the formula 1
    Type: Application
    Filed: February 13, 2002
    Publication date: January 2, 2003
    Inventors: William Glen Harter, Jie Jack Li, Daniel Fred Ortwine, Kevon Ray Shuler, Wen-Song Yue
  • Sulfonamide matrix metalloproteinase inhibitors
    Publication number: 20020169160
    Abstract: Matrix metalloproteinase inhibitors are tricyclic substituted cyclic sulfonamides of the formula 1
    Type: Application
    Filed: February 8, 2002
    Publication date: November 14, 2002
    Inventors: Patrick Michael O'Brien, William Chester Patt, Joseph Armand Picard, Kevon Ray Shuler, Drago Robert Sliskovic
  • Pyridine matrix metalloproteinase inhibitors
    Publication number: 20020161000
    Abstract: Selective MMP-13 inhibitors are pyridine derivatives of the formula 1
    Type: Application
    Filed: February 8, 2002
    Publication date: October 31, 2002
    Inventors: Nicole Chantel Barvian, David Thomas Connor, Patrick Michael O'Brien, Daniel Fred Ortwine, William Chester Patt, Kevon Ray Shuler, Michael William Wilson
  • Dipeptide inhibitors of protein farnesyltransferase
    Patent number: 6265382
    Abstract: The present invention provides compounds having the structure represented by formula (I). Also provided is a method of treating cancer, restenosis, atherosclerosis, or psoriasis or preventing restenosis, and a pharmaceutical composition comprising a compound of formula (I).
    Type: Grant
    Filed: June 28, 1999
    Date of Patent: July 24, 2001
    Assignee: Warner-Lambert Company
    Inventors: Annette Marian Doherty, Daniele Marie Leonard, Dennis Joseph McNamara, Kevon Ray Shuler