Abstract: Methods of manufacturing produce metal implants having nano-modified surfaces that contain antimicrobial properties. The methods may include immersing the implant in an acid, rinsing the acid-treated implant in an aqueous cleaner, and thereafter heating the rinsed implant. The nano-modified implants described herein may contain an increased surface roughness; surface features with increased width or height; and/or decreased surface energy. The implants that result from these methods contain a nano-modified surface that is resistant to microbial cell adhesion and ultimately reduce biomaterials-related infections at the implant site.

Abstract: Methods of manufacturing produce metal implants having nano-modified surfaces that contain antimicrobial properties. The methods may include immersing the implant in an acid, rinsing the acid-treated implant in an aqueous cleaner, and thereafter heating the rinsed implant. The nano-modified implants described herein may contain an increased surface roughness; surface features with increased width or height; and/or decreased surface energy. The implants that result from these methods contain a nano-modified surface that is resistant to microbial cell adhesion and ultimately reduce biomaterials-related infections at the implant site.

Abstract: Methods of manufacturing produce metal implants having nano-modified surfaces that contain antimicrobial properties. The methods may include immersing the implant in an acid, rinsing the acid-treated implant in an aqueous cleaner, and thereafter heating the rinsed implant. The nano-modified implants described herein may contain an increased surface roughness; surface features with increased width or height; and/or decreased surface energy. The implants that result from these methods contain a nano-modified surface that is resistant to microbial cell adhesion and ultimately reduce biomaterials-related infections at the implant site.

Abstract: Methods of manufacturing produce metal implants having nano-modified surfaces that contain antimicrobial properties. The methods may include immersing the implant in an acid, rinsing the acid-treated implant in an aqueous cleaner, and thereafter heating the rinsed implant. The nano-modified implants described herein may contain an increased surface roughness; surface features with increased width or height; and/or decreased surface energy. The implants that result from these methods contain a nano-modified surface that is resistant to microbial cell adhesion and ultimately reduce biomaterials-related infections at the implant site.

Abstract: A method for making an ultra-high weight polyethylene (UHMWPE) medical implant starts with obtaining a preform consolidated from UHMWPE resin. Thereafter the preform is hot isostaticly pressed at a temperature between 150° C. and 190° C. at a pressure up to 30,000 psi. After the hot isostatic pressing the preform is sequentially irradiated in a solid state at a total radiation dose of 2 to 10 MRad. The irradiated UHMWPE preform is then heated to a temperature of about 110° C. to about 190° C. for between 2 to 10 hours. The irradiated and heated preform is then cooled after each irradiation and heating to at or below 50° C., and thereafter a medical implant is formed from the preform. Alternately, the process can be performed on the medical implant itself.

Abstract: A graft fixation device combination. The device is useful for affixing a tissue graft to a bone or other body surface. The fixation device has two implantation members connected by a graft retention member. The retention member optionally has at least one lateral wing member extending therefrom. The implantation members have longitudinal passageways therethrough. The graft fixation device also has an insertion member extending from the distal end of each implantation member, the insertion member having a longitudinal passage having a distal blind wall. The passages of the implantation members and the insertion members are in communication with each other, and may be mounted onto insertion members.

Abstract: A relic process is used to produce bioresorbable ceramic scaffolds that can be used for in vitro or in vivo growth of human or animal tissue such as bone or cartilage. The process involves impregnating an organic fabric template with metal and phosphate ceramic precursors, heat treating the impregnated fabric to decompose the fabric to form a ceramic green body, and sintering the ceramic green body to form the scaffold which has a form analogous to that of the fabric template. Impregnating the fabric may be by soaking the fabric in a solution or sol containing the ceramic precursors. The fabric may be formed into a laminate prior to heat treating. Sintering results in fibers of the fabric being cross-sintered with one another to form a three-dimensional scaffold structure having controlled pore size and distribution. The scaffold may be treated with a material that promotes bone growth through the scaffold.

Abstract: A graft fixation device combination. The device is useful for affixing a tissue graft to a bone or other body surface. The fixation device has two implantation members connected by a graft retention member. The retention member optionally has at least one lateral wing member extending therefrom. The implantation members have longitudinal passageways therethrough. The graft fixation device also has an insertion member extending from the distal end of each implantation member, the insertion member having a longitudinal passage having a distal blind wall. The passages of the implantation members and the insertion members are in communication with each other, and may be mounted onto insertion members.

Abstract: The present invention relates to hard tissue scaffolds comprising a resorbable ceramic, and their method of production. Specifically, this invention relates to novel scaffolds, formed via a replication technique, and useful as biological replacements for hard tissue.