Abstract: The disclosure provides a light-responsive aptamer for regulating the activity of a DNA polymerase. The DNA polymerase includes a G-quadruplex-binding peptide and a polymerase sequence; the polymerase sequence includes an active site; and the light-responsive aptamer includes an aptamer sequence and a photoactive linker connected to the aptamer sequence; the aptamer sequence includes a G-quadruplex-forming sequence and a substrate DNA sequence; the G-quadruplex-forming sequence forms a G-quadruplex, and the substrate DNA sequence folds to form a hairpin structure; the G-quadruplex-forming sequence binds to the G-quadruplex-binding peptide, and the substrate DNA binds to the active site of the DNA polymerase; in the presence of ultraviolet light irradiation (UV irradiation), the photoactive linker is broken, and the substrate DNA is detached from the active site of the DNA polymerase.

Abstract: A primer set for detecting telomerase activity, the primer set including a first primer set or a second primer set. The first primer set includes: an upstream primer selected from MTS; and a downstream primer selected from the group consisting of ACX-M4, Beacon ACX62-2C, and Beacon ACX62-10. The second primer set includes: an upstream primer selected from STS or CTS; and a downstream primer selected from the group consisting of ACX, CXT, ACX-M4, Beacon ACX62-2C, or Beacon ACX62-10. The sequences of the primers ACX, CXT, ACX-M4, Beacon ACX62-2C, Beacon ACX62-10, STS, CTS and MTS are shown as SEQ ID NOs: 1 to 8, respectively.

Abstract: A polypeptide probe for detecting G-quadruplexes (G4s), includes: from two to four G4-binding domains, and one or more linkers disposed between every two G4-binding domains. Each G4-binding domain includes a specific motif including a sequence of amino acids PGHLKGREIGMWY (SEQ ID NO: 1).

Abstract: A modified DNA polymerase includes a DNA polymerase fragment and a G-quadruplex binding peptide fused to an N-terminal of the DNA polymerase fragment.

Abstract: An intermediate code encryption method based on fully homomorphic encryption technology, and a ciphertext virtual machine system; instructions and data of an application in a virtual machine are fully homomorphically encrypted by improving a function key part, and output result ciphertext is obtained by performing ciphertext identification on input data and adopting corresponding homomorphic processing operations, so that running of the virtual machine in an encrypted environment is implemented; according to the present invention, an application is fully homomorphically encrypted, not only data in the program but also instructions of the program are encrypted, and thus, the program logic and structure are protected to the greatest extent.

Abstract: A polypeptide probe, including: from two to four G4-binding domains, and one or more linkers disposed between every two G4-binding domains. Each G4-binding domain includes a specific motif including a sequence of amino acids (SEQ?ID?NO:?1) PGHLKGREIGMWY.

Abstract: A primer set for detecting telomerase activity, the primer set including a first primer set or a second primer set. The first primer set includes: an upstream primer selected from MTS; and a downstream primer selected from the group consisting of ACX-M4, Beacon ACX62-2C, and Beacon ACX62-10. The second primer set includes: an upstream primer selected from STS or CTS; and a downstream primer selected from the group consisting of ACX, CXT, ACX-M4, Beacon ACX62-2C, or Beacon ACX62-10. The sequences of the primers ACX, CXT, ACX-M4, Beacon ACX62-2C, Beacon ACX62-10, STS, CTS and MTS are shown as SEQ ID NOs: 1 to 8, respectively.

Abstract: A polynomial complete homomorphic encryption method based on the coefficient mapping transformation. A plaintext is expressed as a polynomial consisting of a set of random values, two sets of random coefficient factors and a random constant of a specified mapping function, and in the polynomial: the expression and a set of random coefficient factors of the specified mapping function are taken as a key; another set of random coefficient factors, a set of random arguments and random constants of the mapping function are taken as the ciphertexts for homomorphic operations, so that the part of function key performs three different mappings and then undergoes numerical fitting to obtain the family of operational support functions consisting of three sub-functions respectively, which are used to perform the homomorphic operation of the ciphertext based on the family of operational support functions and return to the locality for decryption by the key.

Abstract: A polynomial complete homomorphic encryption method based on the coefficient mapping transformation. A plaintext is expressed as a polynomial consisting of a set of random values, two sets of random coefficient factors and a random constant of a specified mapping function, and in the polynomial: the expression and a set of random coefficient factors of the specified mapping function are taken as a key; another set of random coefficient factors, a set of random arguments and random constants of the mapping function are taken as the ciphertexts for homomorphic operations, so that the part of function key performs three different mappings and then undergoes numerical fitting to obtain the family of operational support functions consisting of three sub-functions respectively, which are used to perform the homomorphic operation of the ciphertext based on the family of operational support functions and return to the locality for decryption by the key.