Abstract: The present application relates to the field of pharmaceutical chemistry, relates to an SOS1 inhibitor containing phosphorus, i.e., a compound of formula (I) and a preparation method therefor, and a pharmaceutical composition containing the compound, and relates to use thereof in the preparation of a drug for treating a disease and/or disorder related to SOS1 or regulated by SOS1.

Abstract: A method may include acquiring real-time data during rig operations that include rig operations for drilling a borehole in a subsurface geologic region using a drillstring that includes a drill bit, where the drillstring includes stands of drill pipe; based on stand statistics, using at least a portion of the real-time data, calibrating a torque and drag model that models torque and drag of the drillstring in the borehole; based on operation statistics, calling for use of the torque and drag model to make a prediction; and, based at least in part on the prediction, detecting an anomaly.

Abstract: A method for monitoring an adherence of actual drilling parameters to planned drilling parameters in real-time includes receiving a well plan for a well. The well plan includes a plurality of planned drilling parameters corresponding to a plurality of intervals in the well. The method also includes receiving actual drilling parameters corresponding to the plurality of intervals in the well and comparing the actual drilling parameters to the planned drilling parameters. The method also includes determining a plurality of compliance indicators based at least partially upon the comparison. The compliance indicators indicate a level of adherence between the actual drilling parameters adhere to the planned drilling parameters. The method also includes generating a first alarm in response to greater than a first predetermined amount and less than a second predetermined amount of the compliance indicators being below a planned minimum threshold, above a planned maximum threshold, or both.

Abstract: A method may include receiving a digital well plan that specifies planned drilling parameters for drilling a borehole, where each of the specified planned drilling parameters includes one or more of a minimum threshold and a maximum threshold; generating statistical distributions of actual drilling parameters in real-time responsive to receipt of real-time data acquired during a depth-based window for the drilling; generating comparisons in real-time, where each of the comparisons is between one of the statistical distributions and a corresponding one of the planned drilling parameters for the depth-based window; and, responsive to one or more of the comparisons indicating an unacceptable actual to planned parameter deviation, issuing a control signal.

Abstract: A method may include acquiring real-time data during rig operations that include rig operations for drilling a borehole in a subsurface geologic region using a drillstring that includes a drill bit, where the drillstring includes stands of drill pipe; based on stand statistics, using at least a portion of the real-time data, calibrating a torque and drag model that models torque and drag of the drillstring in the borehole; based on operation statistics, calling for use of the torque and drag model to make a prediction; and, based at least in part on the prediction, detecting an anomaly.