Abstract: The compound of formula (I) has a good inhibitory effect on the proliferation of human prostate cancer cells CWR22RV1 and breast cancer cells; and combined use of the compound with an androgen receptor inhibitor HC-1119 significantly enhances the inhibitory effect on prostate cancer cells, and the inhibitory effect increases with increased concentration. The compound of formula (I) can not only be used independently to prepare an antineoplastic agent but can also be used in combination with other agents having antineoplastic effects, such as an androgen receptor inhibitor, or other targeting drugs etc., to prepare an antineoplastic agent having stronger therapeutic effects, especially an agent for treating prostate cancer and breast cancer.

Abstract: A synthesis and an application of a phosphatase degrader are provided. The phosphatase degrader is a compound represented by formula I, or a salt thereof, or a deuterated compound thereof, or a stereoisomer thereof, or a solvate thereof, or a hydrate thereof, or a prodrug thereof. The compound can be used as a phosphatase degrader, especially as an SHP2 protein degrader, can treat malignant diseases such as tumors, and has good application prospects.

Abstract: A method and a device of measuring a tissue element, and a wearable apparatus. The method includes: irradiating a measurement region with incident light having a single predetermined wavelength, where the incident light passes through the measurement region to form exit light exited from at least one exit position; obtaining a light intensity value corresponding to the exit light acquired by M photosensitive surfaces so as to obtain T output light intensities, where each output light intensity is obtained by processing the light intensity value of the exit light acquired by one or more photosensitive surfaces, and each photosensitive surface is used to acquire the light intensity value of the exit light exited from the exit position within a predetermined anti-jitter range corresponding to the photosensitive surface, 1?T?M; and determining a concentration of a detected tissue element according to at least one output light intensity corresponding to the predetermined wavelength.

Abstract: A method and a device of measuring tissue element and a wearable apparatus are provided. The method includes: irradiating a measurement region with incident light having multiple predetermined wavelengths, where each beam of the incident light passes through the measurement region to form exit light exited from at least one exit position; obtaining a light intensity value corresponding to each beam of the exit light acquired by M photosensitive surfaces, to obtain T output light intensities each obtained by processing the light intensity value of the exit light acquired by one or more photosensitive surfaces, and each photosensitive surface is used to acquire the light intensity value of the exit light exited from the exit position within a predetermined anti-jitter range corresponding to the photosensitive surface, 1?T?M; and determining a concentration of a measured tissue element according to at least one output light intensity corresponding to the predetermined wavelengths.

Abstract: A method of measuring a tissue element, a device of measuring a tissue element, and a wearable apparatus are provided. The method includes: determining a positioning feature; determining a measurement region according to the positioning feature, where the measurement region meets a reproducibility of a measurement condition; arranging the measurement probe at a position corresponding to the measurement region; and performing a tissue element measurement by using the measurement probe.

Abstract: A method and a device of measuring a tissue element, and a wearable apparatus. The method includes: irradiating a measurement region with incident light having a single predetermined wavelength, where the incident light passes through the measurement region to form exit light exited from at least one exit position; obtaining a light intensity value corresponding to the exit light acquired by M photosensitive surfaces so as to obtain T output light intensities, where each output light intensity is obtained by processing the light intensity value of the exit light acquired by one or more photosensitive surfaces, and each photosensitive surface is used to acquire the light intensity value of the exit light exited from the exit position within a predetermined anti-jitter range corresponding to the photosensitive surface, 1?T?M; and determining a concentration of a detected tissue element according to at least one output light intensity corresponding to the predetermined wavelength.

Abstract: A method and a device of measuring tissue element and a wearable apparatus are provided. The method includes: irradiating a measurement region with incident light having multiple predetermined wavelengths, where each beam of the incident light passes through the measurement region to form exit light exited from at least one exit position; obtaining a light intensity value corresponding to each beam of the exit light acquired by M photosensitive surfaces, to obtain T output light intensities each obtained by processing the light intensity value of the exit light acquired by one or more photosensitive surfaces, and each photosensitive surface is used to acquire the light intensity value of the exit light exited from the exit position within a predetermined anti-jitter range corresponding to the photosensitive surface, 1?T?M; and determining a concentration of a measured tissue element according to at least one output light intensity corresponding to the predetermined wavelengths.

Abstract: A method and a device of detecting a living tissue element and a wearable apparatus are provided. The method includes: irradiating a detection region with incident light, where the incident light passes through the detection region to form exit light exited from at least one exit position; obtaining a light intensity value corresponding to each beam of the exit light acquired by M photosensitive surfaces, to obtain T output light intensities, where each output light intensity is obtained by processing the light intensity value of the exit light acquired by one or more photosensitive surfaces, and each photosensitive surface is used to acquire the light intensity value of the exit light exited from the exit position within a predetermined anti-jitter range corresponding to the photosensitive surface, 1?T?M; and determining a concentration of at least one detected tissue element according to at least one output light intensity.

Abstract: A method and a device of measuring a tissue element, and a wearable apparatus. The method includes: obtaining, in response to a reproducibility of a controllable measurement condition being met, an output light intensity corresponding to exit light having at least one predetermined wavelength, where the output light intensity is acquired by a measurement probe, the measurement probe is provided on a device of measuring a tissue element, and the device of measuring a tissue element has a signal-to-noise ratio level for distinguishing an expected change in a concentration of a tissue element; and processing at least one output light intensity corresponding to the at least one predetermined wavelength based on an interference suppression method, so as to determine a concentration of a detected tissue element.

Abstract: A method of measuring a tissue element, a device of measuring a tissue element, and a wearable apparatus are provided. The method includes: irradiating a measurement region with incident light having at least one predetermined wavelength (S110), where each beam of the incident light is incident on an incident position to form at least one beam of exit light exited from at least one exit position on the measurement region; and arranging an anti-jitter portion at a position corresponding to the measurement region, so that an average optical path of exit light received by a measurement probe associated with the anti-jitter portion is maintained within a predetermined optical path range during a skin jitter process at the measurement region (S120).

Abstract: The embodiments of the present disclosure provide a positioning method, a positioning apparatus, an electronic device and a storage medium. The method includes: acquiring a measurement region of an object; determining a positioning portion of the object according to the measurement region; and positioning the positioning portion to position the measurement region and ensure that a measurement posture meets a predetermined condition.

Abstract: Provided are a method, an apparatus and a system of measuring tissue element, an electronic device, and a medium. The method includes: acquiring a target image information of a target position of a tissue to be measured and a pre-stored template image information of a locating position, the target image information includes a surface target image and/or an internal target image, and the template image information includes a surface template image and/or an internal template image; determining the target position as the locating position in response to the target image information being matched with the template image information; determining a measurement position according to the locating position and a corresponding relationship between the locating position and the measurement position of the tissue to be measured, the measurement position is a position meeting a reproducibility; and performing a tissue element measurement at the measurement position.

Abstract: A non-invasive detection method, device, system and wearable apparatus for tissue element. The method includes: acquiring, for a detected site of a detected object, second light intensity measurement value for each predetermined wavelength of at least one predetermined wavelength at a measurement distance, and/or a second light intensity reference value for each predetermined wavelength of at least one predetermined wavelength at a reference distance, wherein the measurement distance is a source-detection distance corresponding to a first light intensity measurement value, and the reference distance is a source-detection distance corresponding to a first light intensity reference value and determining a concentration of a tissue element to be detected according to the second light intensity measurement value for each predetermined wavelength and/or the second light intensity reference value for each predetermined wavelength.

Abstract: A method and apparatus for processing an image signal, an electronic device, and a computer-readable storage medium. The method includes: obtaining a digital image signal of a target image, the target image including object imaging corresponding to an object, identifying a first area of the object imaging in the target image from the digital image signal, removing the object imaging from the target image based on the first area, to obtain a background image corresponding to an original background, performing image inpainting processing on the first area of the background image to obtain a filled image, the filled image including the original background and a perspective background connected to the original background, identifying a second area in the object imaging, and removing an imaging portion corresponding to the second area from the object imaging, and superimposing the obtained adjusted object imaging on the first area.

Abstract: Disclosed is a BRD4 inhibitor as shown in formula I, belonging to the field of compound drugs. The compound provided has a good inhibitory effect on prostate cancer cell proliferation, and can be used for preparing a drug combatting tumors, autoimmune or inflammatory diseases and viral infection, and in particular an anti-prostate cancer drug.

Abstract: An EP300/CBP inhibitor, specifically provided is a compound as shown in formula I, or a deuterated product thereof, or a salt thereof, or a conformational isomer thereof, or a crystal form thereof, or a solvate thereof. The compound is highly selective for EP300/CBP, and can effectively inhibit the activity of EP300/CBP; in addition, the compound has an excellent inhibitory effect on various tumor cells including prostate cancer cells, leukemia cells, breast cancer cells and multiple myeloma cells. The compound has broad application prospects in the preparation of an EP300/CBP inhibitor, and drugs for preventing and/or treating tumors, myeloid hematopoietic stem/progenitor cells malignant disease, and regulating regulatory T cells.

Abstract: A non-invasive detection method and device, and a wearable apparatus for tissue element are provided. The method includes: acquiring, for a detected site of a detected object, a second light intensity measurement value for each predetermined wavelength of at least one predetermined wavelength at a measurement distance, and/or a second light intensity reference value for each predetermined wavelength of at least one predetermined wavelength at a reference distance, wherein the measurement distance is a source-detection distance corresponding to the first light intensity measurement value, and the reference distance is a source-detection distance corresponding to the first light intensity reference value; and determining a concentration of a tissue element to be detected according to the second light intensity measurement value of each predetermined wavelength and/or the second light intensity reference value for each predetermined wavelength.

Abstract: Described here are methods of assessing response of a patient to an EZH2 inhibitor and methods of treating certain cancers by administering therapeutically effective amounts of an EZH2 inhibitor and a PARP-1 inhibitor.

Abstract: The present disclosure provides a method for correcting a light intensity measurement value is provided. The method includes: emitting detection light into a measured object; measuring a light intensity measurement value at a measurement position, and measuring light intensity of photons at a benchmark position as a light intensity reference value. A sensitivity of the light intensity of photons to a concentration change of a specific substance in the measured object is less than or equal to a preset threshold, and a change rate of the light intensity at the measurement position with a concentration of the specific substance in the measured object is greater than a change rate of the light intensity at the benchmark position with the concentration of the specific substance; correcting the light intensity measurement value by using the light intensity reference value. The present disclosure further provides a concentration measurement device.

Abstract: A compound represented by formula (I), or a stereochemical isomer thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, can inhibit the activity of histone acetylase p300 and inhibit the proliferation activity of a variety of tumor cells.