Patents by Inventor Keyang Xu

Keyang Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11860156
    Abstract: Methods to rapidly and accurately detect, characterize, measure, and quantify site-specific antibody drug conjugates, that may be present in pre-clinical animal biological samples, or human biological samples, including plasma/serum and tissue samples.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: January 2, 2024
    Assignee: Genentech, Inc.
    Inventors: Martine Darwish, Surinder Kaur, Dian Su, Keyang Xu
  • Publication number: 20230296620
    Abstract: The present application relates to systems and methods for assaying presence of large molecule analytes, such as proteins, e.g., antibodies, antigens, receptors, and the like, using a targeted two-dimensional liquid chromatography, tandem mass spectrometry (2D-LC-MS/MS) system, optionally combined with affinity capture. In some aspects, the system is partially or fully automated. In some aspects, the system may allow detection of protein biomarkers (e.g., antibodies or antigens) from clinical or nonclinical biological tissue or fluid samples in the pg/mL to ng/mL range.
    Type: Application
    Filed: October 13, 2022
    Publication date: September 21, 2023
    Applicant: Genentech Inc.
    Inventors: Keyang Xu, Jintang He, Surinder Kaur
  • Publication number: 20210011000
    Abstract: Methods to rapidly and accurately detect, characterize, measure, and quantify site-specific antibody drug conjugates, that may be present in pre-clinical animal biological samples, or human biological samples, including plasma/serum and tissue samples.
    Type: Application
    Filed: May 26, 2020
    Publication date: January 14, 2021
    Applicant: Genentech, Inc.
    Inventors: Martine Darwish, Surinder Kaur, Dian Su, Keyang Xu
  • Publication number: 20170370906
    Abstract: Methods to rapidly and accurately detect, characterize, measure, and quantify site-specific antibody drug conjugates, that may be present in pre-clinical animal biological samples, or human biological samples, including plasma/serum and tissue samples.
    Type: Application
    Filed: May 26, 2017
    Publication date: December 28, 2017
    Applicant: Genentech, Inc.
    Inventors: Martine Darwish, Surinder Kaur, Dian Su, Keyang Xu
  • Publication number: 20160002355
    Abstract: The invention provides anti-idiotypic HCMV antibodies as well as methods of using the same.
    Type: Application
    Filed: September 21, 2015
    Publication date: January 7, 2016
    Inventors: Jo-Anne Hongo, Yanhong Li, Luna Liu, John Lowe, Mauricio Maia, Rajesh Vij, Terence Wong, Keyang Xu
  • Patent number: 9139659
    Abstract: The invention provides anti-idiotypic HCMV antibodies as well as methods of using the same.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 22, 2015
    Assignee: GENENTECH, INC.
    Inventors: Jo-Anne Hongo, Yanhong Li, Luna Liu, John Lowe, Mauricio Maia, Rajesh Vij, Terence Wong, Keyang Xu
  • Patent number: 8679767
    Abstract: Methods are disclosed to detect, characterize, measure, and quantitate human and humanized antibodies, and their conjugates, present in pre-clinical animal biological samples, including plasma/serum and tissue samples.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: March 25, 2014
    Assignee: Genentech, Inc.
    Inventors: Surinder Kaur, Ola Saad, Keyang Xu
  • Publication number: 20130266973
    Abstract: The invention provides anti-idiotypic HCMV antibodies as well as methods of using the same.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 10, 2013
    Inventors: Jo-Anne Hongo, Yanhong Li, Luna Liu, John Lowe, Mauricio Maia, Rajesh Vij, Terence Wong, Keyang XU
  • Patent number: 8541178
    Abstract: Methods to detect, characterize, and quantitate biological samples after administration of antibody conjugates, antibody-drug conjugates of Formula I, antibodies, and fragments and metabolites thereof, by immunoaffinity bead separation, chromatography, and mass spectrometry are disclosed; Ab-(L-D)p??I wherein Ab is an antibody; D is a drug moiety; L is a linker covalently attached to Ab, and covalently attached to D; and p is 1, 2, 3, 4, 5, 6, 7, or 8.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: September 24, 2013
    Assignee: Genentech, Inc.
    Inventors: Surinder Kaur, Ola Saad, Keyang Xu
  • Publication number: 20120315645
    Abstract: Methods are disclosed to detect, characterize, measure, and quantitate human and humanized antibodies, and their conjugates, present in pre-clinical animal biological samples, including plasma/serum and tissue samples.
    Type: Application
    Filed: May 11, 2012
    Publication date: December 13, 2012
    Inventors: Surinder Kaur, Ola Saad, Keyang Xu
  • Publication number: 20090286258
    Abstract: Methods to detect, characterize, and quantitate biological samples after administration of antibody conjugates, antibody-drug conjugates of Formula I, antibodies, and fragments and metabolites thereof, by immunoaffinity bead separation, chromatography, and mass spectrometry are disclosed.
    Type: Application
    Filed: May 12, 2009
    Publication date: November 19, 2009
    Inventors: Surinder Kaur, Ola Saad, Keyang Xu