Patents by Inventor Keyao Pan

Keyao Pan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Techniques for controlling spatial structure of nucleic acid structures based on lattice-free, three dimensional junction coordinates
    Patent number: 10289799
    Abstract: Techniques for controlling nucleic acid structures include determining, for each junction type, values for parameters indicating ground-state geometry and both translational and rotational stiffness coefficients. Topological design data indicates a number of bases in each helix connected to corresponding junctions. Initial positions of each base are determined by connecting helices to junctions using the ground-state geometry and arbitrary coordinates not confined to lattice coordinates. Misalignment vectors each indicate a difference in coordinates and orientations between initial positions of a pair of bases that are not adjacent in the initial positions but are adjacent or coincident in the design data. Forces and moments at the junctions to reduce misalignment magnitudes are determined based on the translational and rotational stiffness coefficients at each junction.
    Type: Grant
    Filed: October 3, 2015
    Date of Patent: May 14, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Mark Bathe, Keyao Pan, Do-Nyun Kim
  • Techniques for Controlling Spatial Structure of Nucleic Acid Structures Based on Lattice-free, Three Dimensional Junction Coordinates
    Publication number: 20160103951
    Abstract: Techniques for controlling nucleic acid structures include determining, for each junction type, values for parameters indicating ground-state geometry and both translational and rotational stiffness coefficients. Topological design data indicates a number of bases in each helix connected to corresponding junctions. Initial positions of each base are determined by connecting helices to junctions using the ground-state geometry and arbitrary coordinates not confined to lattice coordinates. Misalignment vectors each indicate a difference in coordinates and orientations between initial positions of a pair of bases that are not adjacent in the initial positions but are adjacent or coincident in the design data. Forces and moments at the junctions to reduce misalignment magnitudes are determined based on the translational and rotational stiffness coefficients at each junction.
    Type: Application
    Filed: October 3, 2015
    Publication date: April 14, 2016
    Applicant: Massachusetts Institute of Technology
    Inventors: Mark Bathe, Keyao Pan, Do-Nyun Kim