Patents by Inventor Keyi Liu

Keyi Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TOXIN-DERIVED DELIVERY CONSTRUCTS
    Publication number: 20230158163
    Abstract: The present disclosure relates to isolated non-naturally occurring delivery constructs comprising a bacterial toxin-derived delivery construct coupled to a biologically active therapeutic cargo; wherein the delivery construct is capable of delivering the biologically active cargo via transcytosis transport across an epithelial cell; and wherein the delivery construct does not comprise a bacterial toxin-derived translocation domain or a bacterial toxin-derived catalytic (cytotoxic) domain.
    Type: Application
    Filed: July 19, 2022
    Publication date: May 25, 2023
    Inventors: Keyi Liu, Julia Dawn Mackay, Weijun Feng, Thomas Carl Hunter, Randall J. Mrsny
  • COMPOSITIONS AND PARTICLES FOR PAYLOAD DELIVERY
    Publication number: 20220275029
    Abstract: The present disclosure provides complexes and compositions comprising particles, microparticles or nanoparticles, for delivery of payloads into a cell or across a polarized epithelial cell. The compositions can comprise a payload in a pill or tablet for delivery of the payload into or across a polarized epithelial cell.
    Type: Application
    Filed: February 16, 2022
    Publication date: September 1, 2022
    Inventors: Randall J. MRSNY, Derek MACLEAN, Michael SEKAR, Kevin YIN, Tahir Mahmood, Thomas Carl Hunter, Keyi Liu
  • Toxin-derived delivery constructs for pulmonary delivery
    Patent number: 11426466
    Abstract: The present disclosure relates to isolated non-naturally occurring delivery constructs comprising a bacterial toxin-derived delivery construct coupled to a biologically active therapeutic cargo; wherein the delivery construct is capable of delivering the biologically active cargo via transcytosis transport across an epithelial cell; and wherein the delivery construct does not comprise a bacterial toxin-derived translocation domain or a bacterial toxin-derived catalytic (cytotoxic) domain.
    Type: Grant
    Filed: September 8, 2020
    Date of Patent: August 30, 2022
    Assignee: Applied Molecular Transport Inc.
    Inventors: Keyi Liu, Julia Dawn Mackay, Weijun Feng, Thomas Carl Hunter, Randall J. Mrsny
  • NOVEL TOXIN-DERIVED DELIVERY CONSTRUCTS
    Publication number: 20210113704
    Abstract: The present disclosure relates to isolated non-naturally occurring delivery constructs comprising a bacterial toxin-derived delivery construct coupled to a biologically active therapeutic cargo; wherein the delivery construct is capable of delivering the biologically active cargo via transcytosis transport across an epithelial cell; and wherein the delivery construct does not comprise a bacterial toxin-derived translocation domain or a bacterial toxin-derived catalytic (cytotoxic) domain.
    Type: Application
    Filed: September 8, 2020
    Publication date: April 22, 2021
    Inventors: Keyi Liu, Julia Dawn MACKAY, Weijun FENG, Thomas Carl HUNTER, Randall J. MRSNY