Patents by Inventor Keyong Du

Keyong Du has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein kinase B/Akt modulators and methods for the use thereof
    Patent number: 7220539
    Abstract: The present invention describes modulator of protein kinase B (PKB)/Akt proteins, exemplified by the Tribbles (TRB) family. An exemplary member of the TRB family, TRB-3, binds to Akt and inhibits its catalytic activity, in turn causing altered regulation of glucose metabolism pathways. TRB-3 expression is strongly induced in the fasting state, and upregulated in mouse models of type II, causing disruptions in insulin signaling. Accordingly, the present invention further provides compositions and methods for disrupting the interaction between such a modulator and PKB/Akt protein kinases. Also provided are methods of determining if a subject has a predisposition to impaired glucose regulation and methods for treating diabetes mellitus using invention compositions.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: May 22, 2007
    Assignee: The Salk Institute for Biological Studies
    Inventors: Keyong Du, Stephan Herzig, Marc Montminy