Patents by Inventor Keyu LYU

Keyu LYU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of G007-LK in promoting osteogenic differentiation of dental mesenchymal stem cells and bone tissue regeneration
    Patent number: 12540312
    Abstract: Disclosed is a use of G007-LK in promoting osteogenic differentiation of dental mesenchymal stem cells and bone tissue regeneration. In vitro experiments of the present application show that G007-LK has the ability to induce SHED to form mineralized nodules and promote osteogenic differentiation; in vivo experiments show that G007-LK pretreatment of SHED for 7 days combined with Geistlich Bio-Oss® collagen bone scaffold can enhance the in vivo osteogenic effect of SHED and promote the subcutaneous ectopic osteogenesis of nude mice, indicating that G007-LK has good osteoinductivity and is a potential osteogenic drug. Therefore, G007-LK can promote osteogenic differentiation of dental mesenchymal stem cells and be applied to bone tissue regeneration.
    Type: Grant
    Filed: July 15, 2025
    Date of Patent: February 3, 2026
    Assignee: HOSPITAL OF STOMATOLOGY, GUANGZHOU MEDICAL UNIVERSITY
    Inventors: Sujuan Zeng, Ying Fang, Yan Zhang, Jianwen Li, Xi Xiang, Wenyan Huang, Danyuan Xie, Ying Ruan, Keyu Lyu, Jingjing Yang, Feng Zhou, Janak Lal Pathak, Lijing Wang
  • USE OF G007-LK IN PROMOTING OSTEOGENIC DIFFERENTIATION OF DENTAL MESENCHYMAL STEM CELLS AND BONE TISSUE REGENERATION
    Publication number: 20260022339
    Abstract: Disclosed is a use of G007-LK in promoting osteogenic differentiation of dental mesenchymal stem cells and bone tissue regeneration. In vitro experiments of the present application show that G007-LK has the ability to induce SHED to form mineralized nodules and promote osteogenic differentiation; in vivo experiments show that G007-LK pretreatment of SHED for 7 days combined with Geistlich Bio-Oss® collagen bone scaffold can enhance the in vivo osteogenic effect of SHED and promote the subcutaneous ectopic osteogenesis of nude mice, indicating that G007-LK has good osteoinductivity and is a potential osteogenic drug. Therefore, G007-LK can promote osteogenic differentiation of dental mesenchymal stem cells and be applied to bone tissue regeneration.
    Type: Application
    Filed: July 15, 2025
    Publication date: January 22, 2026
    Applicant: HOSPITAL OF STOMATOLOGY, GUANGZHOU MEDICAL UNIVERSITY
    Inventors: Sujuan ZENG, Ying FANG, Yan ZHANG, Jianwen LI, Xi XIANG, Wenyan HUANG, Danyuan XIE, Ying RUAN, Keyu LYU, Jingjing YANG, Feng ZHOU, Janak lal PATHAK, Lijing WANG