Abstract: Methods of using copper (II) complexes of Formula I to prevent and/or treat coronavirus infections, such as SARS-CoV-2 infections, are provided. In Formula I, Y is NO2 or CH3 and X is a C1 to C20 hydrocarbon which is optionally substituted. The copper (II) complexes bind to an inactivate proteins that are necessary for the virus to successfully establish an infection and reproduce.

Abstract: Methods of using copper (II) complexes of Formula I to prevent and/or treat coronavirus infections, such as SARS-CoV-2 infections, are provided. In Formula I, Y is NO2 or CH3 and X is a C1 to C20 hydrocarbon which is optionally substituted. The copper (II) complexes bind to an inactivate proteins that are necessary for the virus to successfully establish an infection and reproduce.

Abstract: Methods of inducing apoptosis of cancer cells by contacting the cancer cells with a pyridine derivative are provided. Methods of treating a subject suffering from a hyperproliferative disease or complications thereof comprising the step of administering a therapeutically effective amount of a composition to the subject, wherein the composition comprises pyridine derivatives are provided.

Abstract: The invention is directed to 2-aryl hydrazonopropanals that exert anti-tumor activity and methods for using them to prevent, inhibit and treat cancer. It also involves anti-tumor compositions containing these 2-aryl hydrazonopropanals, and methods of treatment using these compositions.

Abstract: Small molecules and methods of treating cancer, a bacterial infection, and/or a fungal infection. The small molecules are chromenone derivatives. They have antimicrobial properties and are cytotoxic towards colon, liver, and breast cancer cell lines.

Abstract: Small molecules and methods of treating cancer, a bacterial infection, and/or a fungal infection. The small molecules are chromenone derivatives. They have antimicrobial properties and are cytotoxic towards colon, liver, and breast cancer cell lines.

Abstract: The method for making a phosphorus ylide produces the ylide 2,3-bismethoxycarbonyl-4-phenyl-5-arylhydrazono-cyclopenta-1,3-dienyl-triphenylphosphonium in pure form by simple recrystallization of the reaction product. 3-Oxo-3-phenyl-2-(arylhydrozono)propanal and dimethylacetylenedicarboxylate are mixed in dichloromethane at room temperature. After cyclization of the intermediate (preferably at least two hours), triphenylphosphine is added to the mixture, ultimately resulting in formation of 2,3-bismethoxycarbonyl-4-phenyl-5-arylhydrazono-cyclopenta-1,3-dienyl-triphenylphosphonium. The product is recrystallized to produce 2,3-bismethoxycarbonyl-4-phenyl-5-arylhydrazono-cyclopenta-1,3-dienyl-triphenylphosphonium in pure form and in high yield. The aryl group may be any aromatic or aliphatic group.

Abstract: The method for making a phosphorus ylide produces the ylide 2,3-bismethoxycarbonyl-4-phenyl-5-arylhydrazono-cyclopenta-1,3-dienyl-triphenylphosphonium in pure form by simple recrystallization of the reaction product. 3-Oxo-3-phenyl-2-(arylhydrozono)propanal and dimethylacetylenedicarboxylate are mixed in dichloromethane at room temperature. After cyclization of the intermediate (preferably at least two hours), triphenylphosphine is added to the mixture, ultimately resulting in formation of 2,3-bismethoxycarbonyl-4-phenyl-5-arylhydrazono-cyclopenta-1,3-dienyl-triphenylphosphonium. The product is recrystallized to produce 2,3-bismethoxycarbonyl-4-phenyl-5-arylhydrazono-cyclopenta-1,3-dienyl-triphenylphosphonium in pure form and in high yield. The aryl group may be any aromatic or aliphatic group.