Patents by Inventor Khai Huynh

Khai Huynh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATMENT AND USES FOR CAMKII AND ITS INTERACTION WITH HDACS AND CALPAIN
    Publication number: 20110171196
    Abstract: The present invention provides for methods of treating and cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension comprising the use of CaMKII-HDAC binding domains. The present invention discloses not only the fact that CaMKII binds to HDAC4 at a specific site, but that HDAC4 may dimerize with other HDACs. Both events can lead to export of HDACs from the nucleus to the cytoplasm, an event associated with the development of heart disease. Thus the methods of treatment and the screening methods of the present invention are novel attempts to prevent, treat or identify therapies for cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension.
    Type: Application
    Filed: January 4, 2011
    Publication date: July 14, 2011
    Applicants: The Board of Regents of the University of Texas System, Gilead Sciences, Inc.
    Inventors: JOHANNES BACKS, BROOKE HARRISON, KHAI HUYNH, KEITH KOCH, TIMOTHY A. MCKINSEY, ERIC OLSON, NIKOS PAGRATIS
  • Methods of treatment and uses for CaMKII and its interaction with HDACs and calpain
    Patent number: 7863414
    Abstract: The present invention provides for methods of treating and cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension comprising the use of CaMKII-HDAC binding domains. The present invention discloses not only the fact that CaMKII binds to HDAC4 at a specific site, but that HDAC4 may dimerize with other HDACs. Both events can lead to export of HDACs from the nucleus to the cytoplasm, an event associated with the development of heart disease. Thus the methods of treatment and the screening methods of the present invention are novel attempts to prevent, treat or identify therapies for cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: January 4, 2011
    Assignees: The Board of Regents of the University of Texas Systems, Gilead Sciences, Inc.
    Inventors: Johannes Backs, Brooke Harrison, Khai Huynh, Keith Koch, Timothy A. McKinsey, Eric Olson, Nikos Pagratis
  • SUBSTITUTED ADENINES AND THE USES THEREOF
    Publication number: 20090118220
    Abstract: This invention relates to compounds of Formula I: and their use in the treatment of bacterial infections.
    Type: Application
    Filed: April 2, 2007
    Publication date: May 7, 2009
    Applicant: AstraZeneca AB
    Inventors: Marta Cavero-Tomas, Jenna Harang, Hoan Khai Huynh, Haihong Ni, Suzanne Stokes
  • Methods of Treatment and Uses for CaMKII and Its Interaction with HDACs and Calpain
    Publication number: 20070142285
    Abstract: The present invention provides for methods of treating and cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension comprising the use of CaMKII-HDAC binding domains. The present invention discloses not only the fact that CaMKII binds to HDAC4 at a specific site, but that HDAC4 may dimerize with other HDACs. Both events can lead to export of HDACs from the nucleus to the cytoplasm, an event associated with the development of heart disease. Thus the methods of treatment and the screening methods of the present invention are novel attempts to prevent, treat or identify therapies for cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension.
    Type: Application
    Filed: November 17, 2006
    Publication date: June 21, 2007
    Inventors: Johannes Backs, Brooke Harrison, Khai Huynh, Keith Koch, Timothy McKinsey, Eric Olson, Nikos Pagratis