Patents by Inventor Khai Luong
Khai Luong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240125007Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.Type: ApplicationFiled: December 29, 2023Publication date: April 18, 2024Inventors: Jan BERKA, Carolina DALLETT, Richard DANNEBAUM, Brian GODWIN, Seoyoung KIM, Jainee LEWIS, Khai LUONG, Sedide OZTURK, Joseph PLATZER, Florian RUBELT, Dilduz TELMAN
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Patent number: 11929147Abstract: Described herein are methods for identifying quasispecies of genomes by clustering sequence reads for samples including the genomes based on the similarities of the sequence reads.Type: GrantFiled: September 12, 2018Date of Patent: March 12, 2024Assignee: Roche Sequencing Solutions, Inc.Inventors: Darya Filippova, Khai Luong, Garima Kushwaha
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Publication number: 20240026570Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.Type: ApplicationFiled: August 14, 2023Publication date: January 25, 2024Inventors: Jan BERKA, Carolina DALLETT, Richard DANNEBAUM, Brian GODWIN, Seoyoung KIM, Jainee LEWIS, Khai LUONG, Sedide OZTURK, Joseph PLATZER, Florian RUBELT, Dilduz TELMAN
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Patent number: 11773511Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.Type: GrantFiled: August 18, 2020Date of Patent: October 3, 2023Assignee: Roche Sequencing Solutions, Inc.Inventors: Jan Berka, Carolina Dallett, Richard Dannebaum, Brian Godwin, Seoyoung Kim, Jainee Lewis, Khai Luong, Sedide Ozturk, Joseph Platzer, Florian Rubelt, Dilduz Telman
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Publication number: 20220259667Abstract: The present invention relates generally to classification of biological samples, and more specifically to cell of original classification. In particular, some embodiments of the invention relate to diffuse large B cell lymphoma cell of origin classification using machine learning models. The machine learning models can be based on decision trees such as a random forest algorithm or a gradient boosted decision tree. Features for the models can be determined through analysis of variant data from plasma or blood samples from a plurality of subjects with the disease.Type: ApplicationFiled: July 20, 2020Publication date: August 18, 2022Inventors: David Kurtz, Hai Lin, Alexander Lovejoy, Khai Luong, Ehsan Tabari
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Publication number: 20210172015Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.Type: ApplicationFiled: August 18, 2020Publication date: June 10, 2021Inventors: Jan Berka, Carolina Dallett, Richard Dannebaum, Brian Godwin, Seoyoung Kim, Jainee Lewis, Khai Luong, Sedide Ozturk, Joseph Platzer, Florian Rubelt, Dilduz Telman
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Patent number: 10858651Abstract: Methods are provided for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids, e.g., sequence analysis. The methods result in a subset of the initial population enriched for a target region, which is typically located within one or more target fragments. The methods are particularly useful for analyzing populations having a high degree of complexity, e.g., chromosomal-derived DNA, whole genomic DNA, or mRNA populations.Type: GrantFiled: August 28, 2019Date of Patent: December 8, 2020Assignee: Pacific Biosciences of California, Inc.Inventors: Yu-Chih Tsai, Igor Vilfan, Khai Luong
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Publication number: 20200211675Abstract: Described herein are methods for identifying quasispecies of genomes by clustering sequence reads for samples including the genomes based on the similarities of the sequence reads.Type: ApplicationFiled: September 12, 2018Publication date: July 2, 2020Inventors: Darya FILIPPOVA, Khai LUONG, Garima KUSHWAHA
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Publication number: 20200109396Abstract: Methods are provided for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids, e.g., sequence analysis. The methods result in a subset of the initial population enriched for a target region, which is typically located within one or more target fragments. The methods are particularly useful for analyzing populations having a high degree of complexity, e.g., chromosomal-derived DNA, whole genomic DNA, or mRNA populations.Type: ApplicationFiled: August 28, 2019Publication date: April 9, 2020Inventors: Yu-Chih Tsai, Igor Vilfan, Khai Luong
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Patent number: 10435685Abstract: Methods are provided for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids, e.g., sequence analysis. The methods result in a subset of the initial population enriched for a target region, which is typically located within one or more target fragments. The methods are particularly useful for analyzing populations having a high degree of complexity, e.g., chromosomal-derived DNA, whole genomic DNA, or mRNA populations.Type: GrantFiled: January 14, 2016Date of Patent: October 8, 2019Assignee: Pacific Biosciences of California, Inc.Inventors: Yu-Chih Tsai, Igor Drasko Vilfan, Khai Luong
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Publication number: 20160208241Abstract: Methods are provided for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids, e.g., sequence analysis. The methods result in a subset of the initial population enriched for a target region, which is typically located within one or more target fragments. The methods are particularly useful for analyzing populations having a high degree of complexity, e.g., chromosomal-derived DNA, whole genomic DNA, or mRNA populations.Type: ApplicationFiled: January 14, 2016Publication date: July 21, 2016Inventors: Yu-Chih Tsai, Igor Drasko Vilfan, Khai Luong
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Patent number: 8802424Abstract: Methods, systems and their components for monitoring fluorescent signals and particularly transient fluorescent signals from reaction mixtures of interest, which methods and systems employ modulated excitation light sources to reduce impacts of excessive illumination on the reaction components or the data obtained therefrom.Type: GrantFiled: January 9, 2009Date of Patent: August 12, 2014Assignee: Pacific Biosciences of California, Inc.Inventors: Khai Luong, Paul Lundquist, Ravi Dalal, John Lyle, Stephen Turner
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Publication number: 20110159305Abstract: Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby are described. Hydroxyl or hydroxide groups on the oxide surfaces are reacted with a metal reagent of the formula Y(L-Pol)m, where Y is a transition metal, magnesium or aluminum, L is oxygen, sulfur, selenium or an amine, and “Pol” represents a passivating agent such as a polyethylene glycol, a hydrocarbon, or a fluorocarbon. The resulting modified surface can be further reacted with a passivating agent having a phosphate functional group or a polyvalent reagent comprising a passivating moiety and a plurality of functional groups that are reactive with or that form complexes with Y. The passivating agent can also include a functional group such as biotin to provide surfaces with a desired functionality. The passivated surfaces exhibit minimal binding to bio-molecules and can be used in single-molecule detection schemes.Type: ApplicationFiled: March 10, 2011Publication date: June 30, 2011Applicant: APPLIED BIOSYSTEMS, LLCInventors: Steven M. MENCHEN, Christina E. Inman, Meng Taing, Khai Luong, Handong Li
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Patent number: 7928038Abstract: Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby are described. Hydroxyl or hydroxide groups on the oxide surfaces are reacted with a metal reagent of the formula Y(L-Pol)m, where Y is a transition metal, magnesium or aluminum, L is oxygen, sulfur, selenium or an amine, and “Pol” represents a passivating agent such as a polyethylene glycol, a hydrocarbon, or a fluorocarbon. The resulting modified surface can be further reacted with a passivating agent having a phosphate functional group or a polyvalent reagent comprising a passivating moiety and a plurality of functional groups that are reactive with or that form complexes with Y. The passivating agent can also include a functional group such as biotin to provide surfaces with a desired functionality. The passivated surfaces exhibit minimal binding to bio-molecules and can be used in single-molecule detection schemes.Type: GrantFiled: November 21, 2007Date of Patent: April 19, 2011Assignee: Applied Biosystems, LLCInventors: Steven M. Menchen, Christina E. Inman, Meng Taing, Khai Luong, Handong Li
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Publication number: 20090181396Abstract: Methods, systems and their components for monitoring fluorescent signals and particularly transient fluorescent signals from reaction mixtures of interest, which methods and systems employ modulated excitation light sources to reduce impacts of excessive illumination on the reaction components or the data obtained therefrom.Type: ApplicationFiled: January 9, 2009Publication date: July 16, 2009Applicant: Pacific Biosciences of California, Inc.Inventors: Khai Luong, Paul Lundquist, Ravi Dalal, John Lyle, Stephen Turner
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Patent number: 7486399Abstract: A system is described that is suitable for use in determining the location of leaks of gases having a background concentration. The system is a point-wise backscatter absorption gas measurement system that measures absorption and distance to each point of an image. The absorption measurement provides an indication of the total amount of a gas of interest, and the distance provides an estimate of the background concentration of gas. The distance is measured from the time-of-flight of laser pulse that is generated along with the absorption measurement light. The measurements are formatted into an image of the presence of gas in excess of the background. Alternatively, an image of the scene is superimposed on the image of the gas to aid in locating leaks. By further modeling excess gas as a plume having a known concentration profile, the present system provides an estimate of the maximum concentration of the gas of interest.Type: GrantFiled: February 4, 2008Date of Patent: February 3, 2009Assignee: Sandia CorporationInventors: Thomas A. Reichardt, Amy Khai Luong, Thomas J. Kulp, Sanjay Devdas
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Publication number: 20080176761Abstract: Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby are described. Hydroxyl or hydroxide groups on the oxide surfaces are reacted with a metal reagent of the formula Y(L-Pol)m, where Y is a transition metal, magnesium or aluminum, L is oxygen, sulfur, selenium or an amine, and “Pol” represents a passivating agent such as a polyethylene glycol, a hydrocarbon, or a fluorocarbon. The resulting modified surface can be further reacted with a passivating agent having a phosphate functional group or a polyvalent reagent comprising a passivating moiety and a plurality of functional groups that are reactive with or that form complexes with Y. The passivating agent can also include a functional group such as biotin to provide surfaces with a desired functionality. The passivated surfaces exhibit minimal binding to bio-molecules and can be used in single-molecule detection schemes.Type: ApplicationFiled: November 21, 2007Publication date: July 24, 2008Applicant: APPLERA CORPORATION, APPLIED BIOSYSTEMS GROUPInventors: Steven M. Menchen, Christina E. Inman, Meng Taing, Khai Luong, Handong Li
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Patent number: 7375814Abstract: A system is described that is suitable for use in determining the location of leaks of gases having a background concentration. The system is a point-wise backscatter absorption gas measurement system that measures absorption and distance to each point of an image. The absorption measurement provides an indication of the total amount of a gas of interest, and the distance provides an estimate of the background concentration of gas. The distance is measured from the time-of-flight of laser pulse that is generated along with the absorption measurement light. The measurements are formated into an image of the presence of gas in excess of the background. Alternatively, an image of the scene is superimosed on the image of the gas to aid in locating leaks. By further modeling excess gas as a plume having a known concentration profile, the present system provides an estimate of the maximum concentration of the gas of interest.Type: GrantFiled: March 11, 2005Date of Patent: May 20, 2008Assignee: Sandia CorporationInventors: Thomas A. Reichardt, Amy Khai Luong, Thomas J. Kulp, Sanjay Devdas
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Patent number: 7310142Abstract: Photons emitted from a sample responsive to being excited by laser pulses are directed through a prism onto a photomultiplier tube having several spaced-apart anodes. The prism alters the path of each photon as a function of its wavelength so that the wavelength determines the anode to which the photon is directed. Taps of first and second delay lines that are coupled to respective alternating anodes. When an anode receives the photon, it generates a pulse that propagates through the delay line in opposite directions from its associated tap. A timer determines first and second times from the laser pulse to the pulse reaching the first and second ends of the delay line. The difference between the first and second times corresponds to the wavelength of the emitted photon and the sum of the first and second times corresponds to the emission delay of the emitted photon.Type: GrantFiled: August 22, 2005Date of Patent: December 18, 2007Assignee: Sandia National LaboratoriesInventors: Carl C. Hayden, David W. Chandler, A. Khai Luong
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Publication number: 20060277748Abstract: An inexpensive method to build thin-wall, flush-mounted, electro-conductive rings directly from the conductor leads embedded inside a non-conductive tubular body is described. Such rings, made from a combination of mechanical and chemical processes, are intended for use as cylindrical electrodes when placed inside human tubular organs.Type: ApplicationFiled: June 8, 2005Publication date: December 14, 2006Inventor: Khai Luong