Patents by Inventor Khalid Chakir

Khalid Chakir has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of (R,R)-fenoterol and (R,R)- or (R,S)-fenoterol analogues and their use in treating congestive heart failure
    Patent number: 10562843
    Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: February 18, 2020
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Irving William Wainer, Weizhong Zhu, Khalid Chakir, Rui-Ping Xiao, Darrell R. Abernethy, Farideh M. Beigi Abhari
  • PREPARATION OF (R,R)-FENOTEROL AND (R,R)- OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE
    Publication number: 20190248732
    Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
    Type: Application
    Filed: April 22, 2019
    Publication date: August 15, 2019
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Irving William Wainer, Weizhong Zhu, Khalid Chakir, Rui-Ping Xiao, Darrell R. Abernethy, Farideh M. Beigi Abhari
  • Preparation of (R,R)-fenoterol and (R,R)- or (R,S)-fenoterol analogues and their use in treating congestive heart failure
    Patent number: 10308591
    Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogs which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogs are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogs, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: June 4, 2019
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Irving William Wainer, Weizhong Zhu, Khalid Chakir, Rui-Ping Xiao, Darrell R. Abernethy, Farideh M. Beigi Abhari
  • PREPARATION OF (R,R)-FENOTEROL AND (R,R)- OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE
    Publication number: 20180141894
    Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
    Type: Application
    Filed: January 18, 2018
    Publication date: May 24, 2018
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Irving William Wainer, Weizhong Zhu, Khalid Chakir, Rui-Ping Xiao, Darrell R. Abernethy, Farideh M. Beigi Abhari
  • Preparation of (R,R)-fenoterol and (R,R)- or (R,S)-fenoterol analogues and their use in treating congestive heart failure
    Patent number: 9908841
    Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogs which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogs are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogs, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: March 6, 2018
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Irving William Wainer, Weizhong Zhu, Khalid Chakir, Rui-Ping Xiao, Darrell R. Abernethy, Farideh M. Beigi Abhari
  • PREPARATION OF (R,R)-FENOTEROL AND (R,R)- OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE
    Publication number: 20170081276
    Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
    Type: Application
    Filed: November 9, 2016
    Publication date: March 23, 2017
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Irving William Wainer, Weizhong Zhu, Khalid Chakir, Rui-Ping Xiao, Darrell R. Abernethy, Farideh M. Beigi Abhari
  • Preparation of ()-fenoterol and ()-or ()-fenoterol analogues and their use in treating congestive heart failure
    Patent number: 9522871
    Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: December 20, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Irving William Wainer, Weizhong Zhu, Khalid Chakir, Rui-Ping Xiao, Darrell R. Abernethy, Farideh M. Beigi Abhari
  • PREPARATION OF (R,R)-FENOTEROL AND (R,R)-OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE
    Publication number: 20160009636
    Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
    Type: Application
    Filed: March 6, 2014
    Publication date: January 14, 2016
    Applicant: The USA, as represented by the Secretary, Department of Health and Human Services
    Inventors: Irving William Wainer, Weizhong Zhu, Khalid Chakir, Rui-Ping Xiao, Darrell R. Abernethy, Farideh M. Beigi Abhari
  • PREPARATION OF (R,R)-FENOTEROL AND (R,R)-OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE
    Publication number: 20140187645
    Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
    Type: Application
    Filed: March 6, 2014
    Publication date: July 3, 2014
    Applicant: The USA, as represented by the Secretary, Department of Health and Human Services
    Inventors: Irving William Wainer, Weizhong Zhu, Khalid Chakir, Rui-Ping Xiao, Darrel R. Abernethy, Farideh M. Beigi-Abhari
  • Preparation of ()-fenoterol and ()-or ()-fenoterol analogues and their use in treating congestive heart failure
    Patent number: 8703826
    Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: April 22, 2014
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, National Institutes of Health
    Inventors: Irving W. Wainer, Weizhong Zhu, Khalid Chakir, Rui Ping Xiao, Darrell R. Abernethy, Farideh M. Beigi
  • PREPARATION OF (R,R)-FENOTEROL AND (R,R)-OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE
    Publication number: 20120157543
    Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
    Type: Application
    Filed: December 21, 2011
    Publication date: June 21, 2012
    Inventors: Irving W. Wainer, Weizhong Zhu, Khalid Chakir, Rui Ping Xiao, Darrell R. Abernethy, Farideh M. Beigi
  • PREPARATION OF (R,R)-FENOTEROL AND (R,R)-OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE
    Publication number: 20100168245
    Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
    Type: Application
    Filed: August 10, 2007
    Publication date: July 1, 2010
    Inventors: Irving W. Wainer, Weizhong Zhu, Khalid Chakir, Rui Ping Xiao, Darrell R. Abernethy, Farideh M. Beigi