Patents by Inventor Khalid DIKER

Khalid DIKER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic methods and intermediates for producing compounds for treating KIT- and PDGFRA-mediated diseases
    Patent number: 12698290
    Abstract: The present disclosure provides methods and intermediates for making Compound A or a pharmaceutical salt thereof, and/or a solvate of, which are useful as methods and intermediates for producing compounds for treating diseases and conditions related to mutant KIT and PDGFRA.
    Type: Grant
    Filed: March 3, 2022
    Date of Patent: August 4, 2026
    Assignee: Blueprint Medicines Corporation
    Inventors: Gilles Caillot, Khalid Diker, Brian Heinrich, Christopher Lee, Hui Li, Baptiste Tournade, Andreas Wagner
  • PROCESSES AND INTERMEDIATES FOR PRODUCING DIAZASPIRO LACTAM COMPOUNDS
    Publication number: 20250243211
    Abstract: Processes for producing diazaspiro lactam compounds and intermediates useful in the processes.
    Type: Application
    Filed: December 20, 2024
    Publication date: July 31, 2025
    Inventors: Danny T. DINH, William R. Perrault, Khalid Diker
  • Processes and intermediates for producing diazaspiro lactam compounds
    Patent number: 12215114
    Abstract: Processes for producing diazaspiro lactam compounds and intermediates useful in the processes.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: February 4, 2025
    Assignee: NAUREX INC.
    Inventors: Danny T. Dinh, William R. Perrault, Khalid Diker
  • SYNTHETIC METHODS AND INTERMEDIATES FOR PRODUCING COMPOUNDS FOR TREATING KIT- AND PDGFRA-MEDIATED DISEASES
    Publication number: 20240166650
    Abstract: The present disclosure provides methods and intermediates for making Compound A or a pharmaceutical salt thereof, and/or a solvate of, which are useful as methods and intermediates for producing compounds for treating diseases and conditions related to mutant KIT and PDGFRA.
    Type: Application
    Filed: March 3, 2022
    Publication date: May 23, 2024
    Applicant: Blueprint Medicines Corporation
    Inventors: Gilles Caillot, Khalid Diker, Brian Heinrich, Christopher Lee, Hui Li, Baptiste Tournade, Andreas Wagner
  • PROCESS FOR THE PREPARATION OF A NITRIC OXIDE DONATING PROSTAGLANDIN ANALOGUE
    Publication number: 20240158345
    Abstract: The present invention relates to a process for preparing hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]-3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester of formula (I). In accordance with the present invention, the compound (I) can be efficiently prepared with high purity by coupling bimatoprost in a boronate protected form with 6-(nitrooxy)hexanoyl chloride and removing the boronate protecting group. The invention also relates to a process for the preparation of 6-(nitrooxy) hexanoic acid having a HPLC purity equal to or greater than 99% and containing an amount of 6-{[6-(nitrooxy)hexanoyl]oxy}hexanoic acid (compound (IXa) equal to or lower than 0.2%.
    Type: Application
    Filed: February 3, 2021
    Publication date: May 16, 2024
    Inventors: Nicoletta ALMIRANTE, Gael RONSIN, Khalid DIKER, Gilles GORINS, Jonathan COUSIN, Audrey BRUNEAU
  • Method for preparing dexmedetomidine
    Patent number: 11718586
    Abstract: The present invention relates to a method for preparing dexmedetomidine having the following formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, comprising the following successive steps: a) asymmetric hydrogenation of a methylene derivative of the following formula (II): in order to obtain dexmedetomidine, and b) optionally salifying and/or solvating dexmedetomidine in order to obtain a pharmaceutically acceptable salt and/or solvate of dexmedetomidine, wherein the methylene derivative of formula (II) is prepared from a halide of the following formula (V), in which Hal2 represents a halogen atom such as Br, and a cyanoimidazole of the following formula (VI).
    Type: Grant
    Filed: November 9, 2020
    Date of Patent: August 8, 2023
    Assignee: NORCHIM
    Inventors: Khalid Diker, Gilles Gorins, Aurélie Ozanne-Beaudenon, Corinne Goldstein
  • METHOD FOR PREPARING DEXMEDETOMIDINE
    Publication number: 20220363647
    Abstract: The present invention relates to a method for preparing dexmedetomidine having the following formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, comprising the following successive steps: a) asymmetric hydrogenation of a methylene derivative of the following formula (II): in order to obtain dexmedetomidine, and b) optionally salifying and/or solvating dexmedetomidine in order to obtain a pharmaceutically acceptable salt and/or solvate of dexmedetomidine, wherein the methylene derivative of formula (II) is prepared from a halide of the following formula (V), in which Hal2 represents a halogen atom such as Br, and a cyanoimidazole of the following formula (VI).
    Type: Application
    Filed: November 9, 2020
    Publication date: November 17, 2022
    Applicant: NORCHIM
    Inventors: Khalid DIKER, Gilles GORINS, Aurélie OZANNE-BEAUDENON, Corinne GOLDSTEIN
  • PROCESSES AND INTERMEDIATES FOR PRODUCING DIAZASPIRO LACTAM COMPOUNDS
    Publication number: 20220259217
    Abstract: Processes for producing diazaspiro lactam compounds and intermediates useful in the processes.
    Type: Application
    Filed: June 23, 2020
    Publication date: August 18, 2022
    Inventors: Danny T. DINH, William R. PERRAULT, Khalid DIKER