Abstract: A system, apparatus, and method for removing pressure adhesive indicia, such as labels or stamps, from their backing and affixing the same to a target substrate is provided. The automated process affixes stamps, for example, to the target substrate with both speed and precision of placement. Desired stamps can be selectively removed from a backing, for example, can be placed on variable locations upon the target substrate, and can be affixed in the desired orientation with precise spacing between stamps. The precision of affixation afforded by this system is commensurate with philatelic standards and is suitable for all pressure adhesive indicia where rapid and precise placement is desired for aesthetic or other reasons.

Abstract: A method of illuminating an item is disclosed. The method includes applying adhesive to the item, interspersing a taggant in the adhesive, illuminating the item with an excitation signal, sensing luminescence emitted by the taggant in response to illumination by the excitation signal, and determining the authenticity of the item based on the sensed emitted luminescence. The item can include any item benefited by authentication, and can include a postage stamp. A method of customizing an item is disclosed. This can include the steps of preparing a substrate, applying a security feature to the substrate, printing non-customized information on the substrate, receiving image information, and printing the image information on the substrate.

Abstract: The invention describes a process for the purification of iodinated aryl compounds where the purification is performed by continuous crystallization of a crude product in a solvent with addition of anti-solvent. The continuous crystallization process is performed in one or more crystallizers at a temperature up to the boiling point of the content of the crystallizer.

Abstract: A method of illuminating an item is disclosed. The method includes applying adhesive to the item, interspersing a taggant in the adhesive, illuminating the item with an excitation signal, sensing luminescence emitted by the taggant in response to illumination by the excitation signal, and determining the authenticity of the item based on the sensed emitted luminescence. The item can include any item benefited by authentication, and can include a postage stamp. A method of customizing an item is disclosed. This can include the steps of preparing a substrate, applying a security feature to the substrate, printing non-customized information on the substrate, receiving image information, and printing the image information on the substrate.

Abstract: A process for the manufacture of iodixanol by performing a purification process of the crude product in a solvent comprising 1-methoxy-2-propanol. The crude product may be obtained in aqueous solution from dimerization of 5-acetamido-N,N?-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide (“Compound A”).

Abstract: The invention describes a process for the purification of iodinated aryl compounds where the purification is performed by continuous crystallization of a crude product in a solvent with removal of at least a fraction of the solvent. The continuous crystallization process is performed in one or more crystallizers at the boiling point of the content of the crystallizer.

Abstract: This invention relates to the manufacture of iodixanol (1,3-bis(acetamido)-N,N?-bis[3,5-bis (2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the purification of iodixanol by crystallization by using ultrasound.

Abstract: This invention relates to the manufacture of iodixanol(1,3-bis(acetamido)-N,N?-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the purification of iodixanol by crystallization by using wet milling.

Abstract: This invention relates to an improved method for the synthesis of 5-acetamido-N,N?-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of acetylation of 5-amino-N,N?-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound B”) followed by the removal of acetic anhydride.

Abstract: This invention relates to an improved method for the synthesis of 5-acetamido-N,N?-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of deacetylation of the acetylated hydroxyl group in 5-amino-N,N?-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound B”) followed by crystallisations, filtration, and washing of Compound A.

Abstract: This invention relates to the manufacture of iodixanol(1,3-bis(acetamido)-N,N?-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the purification of iodixanol by crystallization by using wet milling.

Abstract: This invention relates to the manufacture of iodixanol (1,3-bis(acetamido)-N,N?-bis[3,5-bis (2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the purification of iodixanol by crystallization by using ultrasound.

Abstract: Creating a customized item cover comprises receiving customization data and creating at least one customization segment using the customization data. In addition, creating a customized item cover includes producing the customized item cover including the at least one customization segment. Producing the customized item cover may comprise printing the at least one customization segment on the customized item cover or embossing the at least one customization segment on the customized item cover.

Abstract: A process for the manufacture of iodixanol by performing a purification process of the crude product in a solvent comprising 1-methoxy-2-propanol. The crude product may be obtained in aqueous solution from dimerisation of 5-acetamido-N,N?-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide (“Compound A”).

Abstract: The invention describes a process for the purification of iodinated aryl compounds where the purification is performed by continuous crystallisation of a crude product in a solvent with addition of anti-solvent. The continuous crystallisation process is performed in one or more crystallisers at a temperature up to the boiling point of the content of the crystalliser.

Abstract: The present invention relates to a process for the manufacture of iohexol, 5-[N-(2,3-dihydroxypropyl)-acetamido]-N,N?-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophtalamide by selecting a solvent comprising a C1-C5-monoalkylether of a C3-C10 alkylene-glycol.

Abstract: A method is disclosed for creating a pictorial cancellation mark that may be applied to a mailpiece. The pictorial cancellation originates as a digital image that is then printed through a printer on the mailpiece, such as by application to the postal indicia on the mailpiece. This invention takes advantage of the technology now available in digital printing techniques to vary the pictorial cancellation through a variety of color, sizes, shapes, and images. Pictorial cancellations may thus be individualized for markets, applications, and unique purposes.

Abstract: A method is disclosed for providing a pictorial cancellation mark that may be applied to the postage indicia on a mailpiece. The pictorial cancellation originates as a digital image that is then printed through a printer on the mailpiece. This invention takes advantage of the technology now available in digital printing techniques to vary the pictorial cancellation through a variety of color, sizes, shapes, and images. Pictorial cancellations may thus be individualized for markets, applications, and unique purposes.

Abstract: A method is disclosed for providing a pictorial cancellation mark that may be applied to the postage indicia on a mailpiece. The pictorial cancellation originates as a digital image that is then printed through a printer on the mailpiece. This invention takes advantage of the technology now available in digital printing techniques to vary the pictorial cancellation through a variety of color, sizes, shapes, and images. Pictorial cancellations may thus be individualized for markets, applications, and unique purposes.

Abstract: A method is disclosed for providing a pictorial cancellation mark that may be applied to the postage indicia on a mailpiece. The pictorial cancellation originates as a digital image that is then printed through a printer on the mailpiece. This invention takes advantage of the technology now available in digital printing techniques to vary the pictorial cancellation through a variety of color, sizes, shapes, and images. Pictorial cancellations may thus be individualized for markets, applications, and unique purposes.