Patents by Inventor Khanh Le

Khanh Le has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11757532
    Abstract: A telecom system is disclosed with a laser controlled by an acousto-optic deflector including an optical element having a surface with one or more steps formed thereon; a conductive layer formed on the surface with the steps; one or more crystals secured to each step; and electrodes positioned on each surface of each crystal.
    Type: Grant
    Filed: April 7, 2023
    Date of Patent: September 12, 2023
    Assignee: IntraAction Corp.
    Inventors: Khanh Le, John Lekavich, Bao Tran
  • Publication number: 20230016983
    Abstract: The present invention concerns the treatment of prostate cancer and particularly castration resistant prostate cancer (CRPC). The Heat Shock Protein Hsp27, a chaperone protein, has been long demonstrated as a driver of Castration Resistance Prostate Cancer (CRPC). In the light of identification of the molecular mechanisms, the inventor determined that the Probable ATP-dependent RNA helicase DDX5 is an interactor of Hsp27 and DDX5's expression is modulated by Hsp27. They confirmed that DDX5 overexpression is correlated to the aggressiveness of the tumor, to the CRPC emergency and to the biochemical recurrence risk. They also developed DDX5-targeting antisense oligonucleotides for research purpose and clinical application. Thus, the invention relates to an inhibitor of DDX5 wherein said inhibitor reduces the expression and/or activity of DDX5 in a subject in need thereof and targets the gene or the mRNA of DDX5.
    Type: Application
    Filed: November 18, 2020
    Publication date: January 19, 2023
    Inventors: Palma ROCCHI, Thi-Khanh LE, François BERTUCCI, David TAIEB, Clément PARIS, Pascal FINETTI
  • Publication number: 20220332764
    Abstract: The present invention relates to relates to T cell epitope peptides, proteins, nucleic acids and cells for use in immunother-apeutic methods. In particular, the present invention relates to the immunotherapy of viral infection. The present invention specifically relates to virus-associated T-cell peptide epitopes, alone or in combination with other virus-associated peptides that can serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-viral immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
    Type: Application
    Filed: August 28, 2020
    Publication date: October 20, 2022
    Inventors: ANNIKA NELDE, MAREN LÜBKE, STEFANIE SPALT, DANIEL KOWALEWSKI, HANS-GEORG RAMMENSEE, ANNE HALENIUS, COSIMA ZIMMERMANN, HARTMUT HENGEL, LIANE BAUERSFELD, VU THUY KHANH LE-TRILLING
  • Publication number: 20210276929
    Abstract: A method enhances soil by preparing a microbial solution with microbes, a growth medium, and water; iteratively and selectively breeding generations of microbes to arrive at a predetermined microbial solution in a concentrated form of at least 1×107 cfu/ml (colony-forming units per milliliter); adding humic acid with amino acids and protein to support an active microbial population to support active and healthy plant growth; and storing the microbial solution as a solid for enriching the soil with micronutrients, microbial cultures and organic materials.
    Type: Application
    Filed: March 16, 2021
    Publication date: September 9, 2021
    Inventor: Khanh Le
  • Publication number: 20210230081
    Abstract: In one aspect, a method for feeding animals includes selecting a plurality of strains of sporulated living microbes and form a microbial solution; and applying the microbial solution to a carrier. In another aspect during use, the method includes feeding animals with the microbial infused carrier to deliver microbes to a gastrointestinal tract alive; and germinating the microbes in the digestive tract and stimulating local intestinal immunity with the microbes.
    Type: Application
    Filed: December 15, 2020
    Publication date: July 29, 2021
    Inventor: Khanh Le
  • Patent number: 10899676
    Abstract: In one aspect, a method for feeding animals includes selecting a plurality of strains of sporulated living microbes and form a microbial solution; and applying the microbial solution to a carrier. In another aspect during use, the method includes feeding animals with the microbial infused carrier to deliver microbes to a gastrointestinal tract alive; and germinating the microbes in the digestive tract and stimulating local intestinal immunity with the microbes.
    Type: Grant
    Filed: November 23, 2019
    Date of Patent: January 26, 2021
    Assignee: Cisbay Global Inc.
    Inventor: Khanh Le
  • Publication number: 20200299164
    Abstract: A method to remediate water includes preparing a microbial solution with microbes, a growth medium, and water; iteratively and selectively breeding generations of microbes to arrive at a predetermined microbial solution in a highly concentrated form of at least 1×109 cfu/ml (colony-forming units per milliliter); and dispensing the microbial solution into the water, wherein the microbes metabolizes excess nutrients and uses microbial desalination to reduce water salinity.
    Type: Application
    Filed: November 2, 2018
    Publication date: September 24, 2020
    Inventor: Khanh Le
  • Publication number: 20200189988
    Abstract: In one aspect, a method for feeding animals includes selecting a plurality of strains of sporulated living microbes and form a microbial solution; and applying the microbial solution to a carrier. In another aspect during use, the method includes feeding animals with the microbial infused carrier to deliver microbes to a gastrointestinal tract alive; and germinating the microbes in the digestive tract and stimulating local intestinal immunity with the microbes.
    Type: Application
    Filed: November 23, 2019
    Publication date: June 18, 2020
    Inventor: Khanh Le
  • Publication number: 20200078841
    Abstract: A method for forming soil enhancement includes forming microbes in a concentrated form of at least 1×107 cfu/ml (colony-forming units per milliliter); and dry forming the microbes onto humic acid.
    Type: Application
    Filed: August 15, 2019
    Publication date: March 12, 2020
    Inventor: Khanh Le
  • Publication number: 20200079703
    Abstract: Systems and methods are disclosed to provide plant nutrient by selecting a series of microbes optimal for plant growing; mixing the microbes, urea and humic acid in a mixture; and combining the mixture with a fertilizer.
    Type: Application
    Filed: March 15, 2019
    Publication date: March 12, 2020
    Inventor: Khanh Le
  • Publication number: 20200055793
    Abstract: Systems and methods are disclosed to provide a plant nutrient by selecting a microbial solution with predetermined characteristics for agriculture use; iteratively and selectively breeding generations of microbes for microbial strain selection with predetermined microbial gene profiles to arrive at a predetermined microbial solution, wherein multiple single microbial series are separately cultivated and followed with cross cultivation among the microbial series in a specific sequence; and mixing by-products produced by the crossly cultivated microbial series with a fertilizer, a mineral or both.
    Type: Application
    Filed: February 22, 2019
    Publication date: February 20, 2020
    Inventor: Khanh Le
  • Patent number: 10524487
    Abstract: In one aspect, a method for feeding animals includes selecting a plurality of strains of sporulated living microbes and form a microbial solution; and applying the microbial solution to a carrier. In another aspect during use, the method includes feeding animals with the microbial infused carrier to deliver microbes to a gastrointestinal tract alive; and germinating the microbes in the digestive tract and stimulating local intestinal immunity with the microbes.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: January 7, 2020
    Assignee: Cisbay
    Inventor: Khanh Le
  • Publication number: 20190352597
    Abstract: Systems and methods for cleaning a water dispenser by preparing a bioremediation solution with microbes, a growth medium, and water; injecting the bioremediation solution into a water supply; and flushing the water supply with the bioremediation solution.
    Type: Application
    Filed: November 15, 2018
    Publication date: November 21, 2019
    Inventor: Khanh Le
  • Publication number: 20190169078
    Abstract: A method enhances soil by preparing a microbial solution with microbes, a growth medium, and water; iteratively and selectively breeding generations of microbes to arrive at a predetermined microbial solution in a concentrated form of at least 1×107 cfu/ml (colony-forming units per milliliter); adding humic acid with amino acids and protein to support an active microbial population to support active and healthy plant growth; and storing the microbial solution as a solid for enriching the soil with micronutrients, microbial cultures and organic materials.
    Type: Application
    Filed: January 17, 2019
    Publication date: June 6, 2019
    Inventor: Khanh Le
  • Publication number: 20190169079
    Abstract: Systems and methods are disclosed to provide a plant nutrient by selecting a microbial solution with predetermined characteristics for agriculture use; iteratively and selectively breeding generations of microbes for microbial strain selection with predetermined microbial gene profiles to arrive at a predetermined microbial solution in a highly concentrated form of at least 1×107 cfu/ml (colony-forming units per milliliter), wherein multiple single microbial series are separately cultivated and followed with cross cultivation among the microbial series in a specific sequence; and mixing by-products produced by the crossly cultivated microbial series with humic acid and a filler.
    Type: Application
    Filed: January 29, 2019
    Publication date: June 6, 2019
    Inventor: Khanh Le
  • Patent number: 10221107
    Abstract: A method enhances soil by preparing a microbial solution with microbes, a growth medium, and water; iteratively and selectively breeding generations of microbes to arrive at a predetermined microbial solution in a concentrated form of at least 1×107 cfu/ml (colony-forming units per milliliter); adding humic acid with amino acids and protein to support an active microbial population to support active and healthy plant growth; and storing the microbial solution as a solid for enriching the soil with micronutrients, microbial cultures and organic materials.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: March 5, 2019
    Assignee: Cisbay Global Inc.
    Inventor: Khanh Le
  • Patent number: 10179744
    Abstract: A method to remediate water includes preparing a microbial solution with microbes, a growth medium, and water; iteratively and selectively breeding generations of microbes to arrive at a predetermined microbial solution in a highly concentrated form of at least 1×109 cfu/ml (colony-forming units per milliliter); and dispensing the microbial solution into the water, wherein the microbes metabolizes excess nutrients and uses microbial desalination to reduce water salinity.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: January 15, 2019
    Assignee: Cisbay Global Inc.
    Inventor: Khanh Le
  • Patent number: 10174283
    Abstract: Systems and methods for cleaning a water dispenser by preparing a bioremediation solution with microbes, a growth medium, and water; injecting the bioremediation solution into a water supply; and flushing the water supply with the bioremediation solution.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: January 8, 2019
    Assignee: Cisbay Global Inc.
    Inventor: Khanh Le
  • Publication number: 20180312448
    Abstract: A method for enhancing soil in a predetermined farming area includes selecting a plurality of strains of sporulated living microbes and form a microbial solution; infusing the microbes with a carrier for a predetermined animal; feeding the animal with the microbes infused carrier; excrementing the microbes infused carrier as the animal moves around the area to receive the soil enhancement; and upon receipt of liquid, activating the microbes to perform soil enhancement.
    Type: Application
    Filed: April 27, 2017
    Publication date: November 1, 2018
    Inventor: Khanh Le
  • Publication number: 20180311712
    Abstract: A method for forming soil enhancement includes forming microbes in a concentrated form of at least 1×107 cfu/ml (colony-forming units per milliliter); and dry forming the microbes onto humic acid.
    Type: Application
    Filed: April 27, 2017
    Publication date: November 1, 2018
    Inventor: Khanh Le