Patents by Inventor Khanhlinh Nguyen

Khanhlinh Nguyen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxysterol compounds and the hedgehog pathway
    Patent number: 9670244
    Abstract: This invention relates, for example, to synthetic oxysterols. Also described are methods for using the compounds, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: June 6, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Farhad Parhami, Michael E. Jung, Jennifer R. Dwyer, Khanhlinh Nguyen
  • Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling
    Patent number: 9526737
    Abstract: Synthetic oxysterols can be made and can be used for the treatment of bone disorders, obesity, cardiovascular disorders, and neurological disorders.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: December 27, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Farhad Parhami, Michael E. Jung, Khanhlinh Nguyen, Dongwon Yoo, Woo-Kyun Kim
  • OXYSTEROLS THAT ACTIVATE LIVER X RECEPTOR SIGNALING AND INHIBIT HEDGEHOG SIGNALING
    Publication number: 20160206631
    Abstract: This invention relates, e.g., to compositions comprising oxysterol compounds represented by Formula I or Formula II, e.g., comprising one or more of Oxy 16, Oxy 22, Oxy30, Oxy 31, Oxy35, Oxy37, Oxy43, Oxy44, Oxy45 or Oxy47. The compounds are shown to be Hedgehog pathway inhibiting, and to act as agonists for liver X receptor (LXR). Also disclosed are methods of using compositions of the invention to inhibit Hedgehog signaling effects, such as cell proliferation, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.
    Type: Application
    Filed: November 18, 2015
    Publication date: July 21, 2016
    Applicants: JOHNS HOPKINS UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Farhad PARHAMI, Michael JUNG, Khanhlinh NGUYEN, Dongwon YOO, William MATSUI
  • OXYSTEROLS THAT ACTIVATE LIVER X RECEPTOR SIGNALING AND INHIBIT HEDGEHOG SIGNALING
    Publication number: 20120309730
    Abstract: This invention relates, e.g., to compositions comprising oxysterol compounds represented by Formula I or Formula II, e.g., comprising one or more of Oxy 16, Oxy 22, Oxy30, Oxy 31, Oxy35, Oxy37, Oxy43, Oxy44, Oxy45 or Oxy47. The compounds are shown to be Hedgehog pathway inhibiting, and to act as agonists for liver X receptor (LXR). Also disclosed are methods of using compositions of the invention to inhibit Hedgehog signaling effects, such as cell proliferation, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.
    Type: Application
    Filed: February 16, 2011
    Publication date: December 6, 2012
    Applicants: The Johns Hopkins University, The Regents of the University of California
    Inventors: Farhad Parhami, Michael Jung, Khanhlinh Nguyen, Dongwon Yoo, VIncente Meliton
  • Inhibition of PPAR gamma expression by specific osteogenic oxysterols
    Patent number: 8022052
    Abstract: This invention relates to methods for using agents to inhibit peroxisome proliferator activated receptor expression.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: September 20, 2011
    Assignee: The Regents of the University of California
    Inventors: Farhad Parhami, Woo-Kyun Kim, Michael E. Jung, Khanhlinh Nguyen
  • OXYSTEROLS FOR ACTIVATION OF HEDGEHOG SIGNALING, OSTEOINDUCTION, ANTIADIPOGENESIS, AND WNT SIGNALING
    Publication number: 20110008297
    Abstract: Synthetic oxysterols can be made and can be used for the treatment of bone disorders, obesity, cardiovascular disorders, and neurological disorders.
    Type: Application
    Filed: December 3, 2008
    Publication date: January 13, 2011
    Applicant: The Regents of the University of California
    Inventors: Farhad Parhami, Michael E. Jung, Khanhlinh Nguyen, Dongwon Yoo, Woo-Kyun Kim
  • ROLE OF HEDGEHOG SIGNALING IN ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASE
    Publication number: 20100112030
    Abstract: The present invention provides methods and related compositions for treating or preventing cardiovascular diseases, including, e.g., atherosclerosis, using an oxysterol. In addition, the present invention provides novel methods and related compositions for treating or preventing cardiovascular diseases, including, e.g., atherosclerosis, using a hedgehog protein, or a biologically active fragment or variant thereof.
    Type: Application
    Filed: March 17, 2008
    Publication date: May 6, 2010
    Applicant: The Regents of the University of California
    Inventors: Farhad Parhami, Michael E. Jung, Khanhlinh Nguyen, Dongwon Yoo
  • INHIBITION OF PPAR GAMMA EXPRESSION BY SPECIFIC OSTEOGENIC OXYSTEROLS
    Publication number: 20100105645
    Abstract: This invention relates to methods for using agents to inhibit peroxisome proliferator activated receptor expression.
    Type: Application
    Filed: December 19, 2007
    Publication date: April 29, 2010
    Applicant: The Regents of the University of California
    Inventors: Farhad Parhami, Woo-Kyun Kim, Michael E. Jung, Khanhlinh Nguyen
  • Oxysterol Compounds and the Hedgehog Pathway
    Publication number: 20100034781
    Abstract: This invention relates, for example, to synthetic oxysterols. Also described are methods for using the compounds, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.
    Type: Application
    Filed: February 27, 2007
    Publication date: February 11, 2010
    Applicant: The Regents of the University of California
    Inventors: Farhad Parhami, Michael E. Jung, Jennifer R. Dwyer, Khanhlinh Nguyen