Patents by Inventor Khashayar Karimian

Khashayar Karimian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190240144
    Abstract: An oral pharmaceutical formulation for effervescent tablet of deferiprone is reported comprising of deferiprone and a taste-masking composition consisting of an effective amount of sweetener and flavoring agent and containing appropriate amount of alkali earth metal bicarbonate or carbonate and an organic carboxylic to afford a final acid pH of about 3.
    Type: Application
    Filed: August 17, 2016
    Publication date: August 8, 2019
    Inventor: Khashayar KARIMIAN
  • Publication number: 20190211150
    Abstract: The present invention is related to a product for the resolution of racemic mixtures in which various separation processes of a salt composed of a PEGylated resolving agent and an enantiomer in a racemic mixture is utilized. Separation can be caused by temperature-dependent phase transformation of the said salt pair in aqueous or organic media as well as other methods used is separation of PEG such as salting out (e.g. addition of ammonium sulfate). The first cycle of racemic resolution by this method was shown to afford 85% optically pure amino acid from a 50:50 mixture of racemic L,D-amino acids esters. An additional cycle improved optical purity up to 95%.
    Type: Application
    Filed: August 22, 2017
    Publication date: July 11, 2019
    Inventor: Khashayar KARIMIAN
  • Publication number: 20060183890
    Abstract: Azithromycin isopropanolate of the empirical formula azithromycin:[H20]x:[isopropanol]y is obtained from the crystallization of azithromycin in isopropanol and water. The x and y values is confirmed by single X-ray diffraction determination. In one embodiment x=1.5 and y=0.25. In another embodiment x=0.75 and y=0.5.
    Type: Application
    Filed: March 19, 2004
    Publication date: August 17, 2006
    Inventors: Tim Tam, Khashayar Karimian, Shui Hu, Anna Chow, Richard Storey
  • Publication number: 20030225007
    Abstract: A method of inhibiting the activity of transglutaminases containing a cysteine residue comprising administering to a mammal an effective amount of a sulfonamide derivative of imidazo[1,2-d]-1,2,4-thiadiazoles sufficient to inhibit the activity.
    Type: Application
    Filed: March 27, 2003
    Publication date: December 4, 2003
    Applicant: Apotex Inc.
    Inventors: Tim Fat Tam, Khashayar Karimian, Regis C.S.H. Leung-Toung, Yanqing Zhao, Jolanta Maria Wodzinska, Wanren Li, Jayme Nicole Lowrie
  • Patent number: 6506929
    Abstract: A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2′-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure.
    Type: Grant
    Filed: April 24, 2001
    Date of Patent: January 14, 2003
    Assignee: Apotex Inc.
    Inventors: Khashayar Karimian, Tim Fat Tam, Yong Tao, Yiwei Li, Gary Doucette
  • Patent number: 6468977
    Abstract: Novel 1,2,4-thiadiazole compounds are provided, which are effective as inhibitors of cysteine activity-dependent enzymes and in particular of cysteine proteases. The compounds are useful in treating acne by inhibition of transglutaminase, common cold by inhibition of human rhinovirus 3C protease and inflammatory joint disease by inhibition of cathepsins. The compounds of the present invention are 3,5-disubstituted 1,2,4-thiadazole of the general formula (I): where Z is a nitrogen containing group with recognition sequence for the enzyme and Y is a substituent that tunes the reactivity of the inhibitor towards the thiol group of the cysteine activity-dependent enzyme. The Y group may also serve in recognition.
    Type: Grant
    Filed: May 23, 2000
    Date of Patent: October 22, 2002
    Assignee: Apotex Inc.
    Inventors: Khashayar Karimian, Tim Fat Tam, Regis C. S. H. Leung-Toung, Wanren Li, Steve Patrick Bryson, Jolanta Maria Wodzinska
  • Patent number: 6245903
    Abstract: A novel form of azithromycin and processes for preparation of pure azithromycin monohydrate isopropanol clathrate (3 molecules of isopropanol for every 10 molecules of azithromycin monohydrate) has been obtained. Preparation of the novel form of azithromycin comprises the steps of dissolving azithromycin in isopropanol, followed by the slow addition of water to the organic solution.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: June 12, 2001
    Assignee: Apotex, Inc.
    Inventors: Khashayar Karimian, Mehrnoush Motamedi
  • Patent number: 6162791
    Abstract: Novel 1,2,4-thiadiazole compounds are provided, which are effective as inhibitors of cysteine activity-dependent enzymes and in particular of cysteine proteases. The compounds are useful in treating acne by inhibition of transglutaminase, common cold by inhibition of human rhinovirus 3C protease and inflammatory joint disease by inhibition of cathepsins. The compounds of the present invention are 3,5-disubstituted 1,2,4-thiadazole of the general formula (I): ##STR1## where Z is a nitrogen containing group with recognition sequence for the enzyme and Y is a substituent that tunes the reactivity of the inhibitor towards the thiol group of the cysteine activity-dependent enzyme. The Y group may also serve in recognition.
    Type: Grant
    Filed: March 2, 1998
    Date of Patent: December 19, 2000
    Assignee: Apotex Inc.
    Inventors: Khashayar Karimian, Tim Fat Tam, Regis C. S. H. Leung-Toung, Wanren Li
  • Patent number: 6114537
    Abstract: Thiols are trapped, and converted to disulfide compounds, by a process of reacting them with compounds containing a 1,2,4-thiadiazole ring structure carrying a substituent at position 3 of the thiadiazole ring, and being unsubstituted at position N-2. The process is useful pharmacologically, in inhibiting certain thiol-containing enzymes such as H.sup.+ /K.sup.+ -ATPase (the proton pump), and industrially, in selective removal of thiol compounds from gas or liquid mixtures.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: September 5, 2000
    Assignee: Apotex Inc.
    Inventors: Khashayar Karimian, Tim F. Tam, Denis Desilets, Sue Lee, Tullio Cappelletto, Wanren Li
  • Patent number: 6093738
    Abstract: Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H.sup.+ /K.sup.+ -ATPase. The compounds are 3-substituted 1,2,4-thiadiazolo [4,5-.alpha.]benzimidazole and 3-substituted imidazo[1,2-d]-1,2,4-thiadiazoles corresponding to the general formula: ##STR1## where X and Z either represent an optionally substituted benzene ring fused to the diazole nucleus, or represent a variety of independent chemical groupings (hydrogen, lower alkyl, halo, etc.) and Y is selected from a wide range, e.g. heterocyclics and carbonyl groups.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: July 25, 2000
    Inventors: Khashayar Karimian, Tim F. Tam, Denis Desilets, Sue Lee, Tullio Cappelletto, Wanren Li
  • Patent number: 6080860
    Abstract: Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediates suitable for use in such methods of synthesis are taught.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: June 27, 2000
    Assignee: Brantford Chemicalss Inc.
    Inventors: Khashayar Karimian, Keshava Murthy, Darren Hall
  • Patent number: 6063933
    Abstract: The present invention relates to a process to prepare a compound of formula (I) wherein Y and Z can be identical or different and represent a halogene. The bis-triazole compounds of formula (I) and intermediates have antifungal activity.
    Type: Grant
    Filed: February 24, 1998
    Date of Patent: May 16, 2000
    Assignees: Khashayar Karimian, Tim F. Tam, John F. Braganza, Yuri Goldberg, Salvatore Zinghini
    Inventors: Khashayar Karimian, Tim F. Tam, John F. Braganza, Yuri Goldberg, Salvatore Zinghini
  • Patent number: 6060472
    Abstract: Novel 3,5-disubstituted 1,2,4-thiadiazole compounds are provided, which are effective in treating peptic ulcers by the inhibition of H.sup.+ /K.sup.+ -ATPase. The compounds of the present invention are 3,5-disubstituted 1,2,4-thiadiazole corresponding to the general formula (I): ##STR1## where R.sup.1 is a group with cell penetration properties for the inhibition of the enzyme in-vitro and in-vivo, and Y is a substituent that tunes the reactivity of the inhibitor towards the cysteine residue of H.sup.+ /K.sup.+ -ATPase. The Y group may also serve in recognition.
    Type: Grant
    Filed: April 6, 1998
    Date of Patent: May 9, 2000
    Assignee: Apotex Inc.
    Inventors: Khashayar Karimian, Tim Fat Tam, Regis C. S. H. Leung-Toung, Wanren Li
  • Patent number: 6046332
    Abstract: The present invention relates to a process for the preparation of a [2-[4-[4-(chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid derivative of formula I: and, in particular, for the preparation of cetirizine. The method comprises the oxidation of a primary alcohol of a hydroxyzine. Cetirizine is a non-sedating type histamine H1-receptor antagonist and is used in the treatment of allergic syndromes.
    Type: Grant
    Filed: January 20, 1999
    Date of Patent: April 4, 2000
    Inventors: Yong Tao, Khashayar Karimian, Tim Fat Tam
  • Patent number: 5914401
    Abstract: Novel process for the preparation of quinolone carboxylic acid derivatives of general formula I, and intermediates thereof as illustrated in Scheme 1 wherein the key intermediate is a compound of formula IX.
    Type: Grant
    Filed: March 11, 1998
    Date of Patent: June 22, 1999
    Assignee: Apotex, Inc.
    Inventors: Ian Egle, Regis C.S.H. Leung-Toung, Bo Lei, Tim Fat Tam, Tao Xin, Khashayar Karimian
  • Patent number: 5900485
    Abstract: Process for the manufacture of triazolone compounds and in particular nefazodone and intermediates useful in the manufacture thereof.
    Type: Grant
    Filed: October 15, 1997
    Date of Patent: May 4, 1999
    Assignee: Apotex, Inc.
    Inventors: Bo Lei, Tim Fat Tam, Khashayar Karimian, Rudolf Kubela
  • Patent number: 5847118
    Abstract: A process for preparing pure amorphous cefuroxime axetil comprising the steps of dissolving crystalline cefuroxime axetil in a highly polar organic solvent and adding the resulting solution to water, or alternatively, dissolving crystalline cefuroxime axetil in a highly polar solvent and adding small quantities of water to the organic solution and adding the resulting organic-aqueous solution to water.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: December 8, 1998
    Assignee: Apotex, Inc.
    Inventors: Khashayar Karimian, Mehrnoush Motamedi, Salvatore Zinghini
  • Patent number: 5817875
    Abstract: Process for the manufacture of naphthylmethylamine derivatives and among them terbinafine as potential antimycotic agents.
    Type: Grant
    Filed: September 19, 1996
    Date of Patent: October 6, 1998
    Inventors: Khashayar Karimian, Regis C. H. S. Leung-Toung, Yiwei Li, Tim Fat Tam
  • Patent number: 5723618
    Abstract: The invention relates to a novel process to prepare 1,4-dihydropyridines and in particular amlopidine and in novel intermediates obtained during the synthesis of the 1,4-dihydropyridines which have potential activity as antihypertensive agents.
    Type: Grant
    Filed: October 10, 1996
    Date of Patent: March 3, 1998
    Assignee: Apotex, Inc.
    Inventors: Regis Chung Soon Hin Leung-Toung, Khashayar Karimian, Tim Fat Tam
  • Patent number: RE39087
    Abstract: A novel form of azithromycin and processes for preparation of pure azithromycin monohydrate isopropanol clathrate (3 molecules of isopropanol for every 10 molecules of azithromycin monohydrate) has been obtained. Preparation of the novel form of azithromycin comprises the steps of dissolving azithromycin in isopropanol, followed by the slow addition of water to the organic solution.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: May 2, 2006
    Assignee: Apotex, Inc.
    Inventors: Khashayar Karimian, Mehrnoush Motamedi