Patents by Inventor Khehyong Ngu

Khehyong Ngu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • UBIQUITIN SPECIFIC PROCESSING PROTEASE 1 (USP1) COMPOUNDS
    Publication number: 20250145590
    Abstract: Compounds having the following formula I or a stereoisomer or pharmaceutically-acceptable salt thereof, where all substituents are as defined herein, are inhibitors of USP1 useful for treating diseases including, among others, treating proliferative, metabolic, allergic, autoimmune and inflammatory diseases.
    Type: Application
    Filed: October 30, 2024
    Publication date: May 8, 2025
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: KHEHYONG NGU, ROBERT J. CHERNEY, YANTING HUANG, WEI MENG, MURALI T.G. DHAR, LI-QIANG SUN, ZHIZHEN BARBARA ZHENG, JAMES AARON BALOG
  • KRAS G12D INHIBITORS
    Publication number: 20240317769
    Abstract: The present disclosure relates to KRAS inhibitors. Methods of treating cancers using the compounds are also provided.
    Type: Application
    Filed: March 14, 2022
    Publication date: September 26, 2024
    Applicant: Bristol-Myers Squibb Company
    Inventors: Brian Edward FINK, Robert Joseph CHERNEY, Khehyong NGU, Upender VELAPARTHI, Wayne David VACCARO, Zheming RUAN, Lan-Ying QIN, Pravin S. SHIRUDE, Hasibur RAHAMAN
  • KRAS INHIBITORS
    Publication number: 20240217982
    Abstract: The present disclosure relates to KRAS inhibitors. Methods of treatment cancers using the compounds are also provided.
    Type: Application
    Filed: March 14, 2022
    Publication date: July 4, 2024
    Inventors: Brian Edward FINK, Robert Joseph CHERNEY, Khehyong NGU, Upender VELAPARTHI, Wayne David VACCARO, Zheming RUAN, Lan-Ying QIN, Pravin S. SHIRUDE, Hasibur RAHAMAN
  • KRAS INHIBITORS
    Publication number: 20240199584
    Abstract: The present disclosure provides KRAS inhibitors. Methods of treating cancers using the compounds are also provided.
    Type: Application
    Filed: August 16, 2023
    Publication date: June 20, 2024
    Inventors: Brian Edward Fink, Khehyong Ngu, Pravin S. Shirude, Manoranjan Panda, Prasada Rao Jalagam, Laxmi Narayan Nanda, Vishweshwaraiah Baligar, Balaji Seshadri, Excel Merlin Soosairaj, Maximilian David Palkowitz, Amit Kumar Chattopadhyay
  • MACROCYCLIC PAD4 INHIBITORS USEFUL AS IMMUNOSUPPRESSANT
    Publication number: 20230203039
    Abstract: The present invention provides compounds of Formula (I) useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders, (I) wherein ring A, A1, A2, A3, A4, Q, R1, R2, R3, R4, R5, and R6 along with other variables are as defined herein.
    Type: Application
    Filed: February 5, 2021
    Publication date: June 29, 2023
    Inventors: Khehyong Ngu, Christopher Annunziato, John V. Duncia, Daniel Gardner
  • INDOLE CARBOXAMIDE COMPOUNDS
    Publication number: 20230192645
    Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Application
    Filed: February 23, 2023
    Publication date: June 22, 2023
    Inventors: Qingjie Liu, Scott Hunter Watterson, John E. Macor, Khehyong Ngu, Saleem Ahmad
  • Indole carboxamide compounds
    Patent number: 11623921
    Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: April 11, 2023
    Assignee: Bristol-Myers Squibb Company
    Inventors: Qingjie Liu, Scott Hunter Watterson, John E. Macor, Khehyong Ngu, Saleem Ahmad
  • SUBSTITUTED BENZIMIDAZOLES AS PAD4 INHIBITORS
    Publication number: 20220402950
    Abstract: The present invention provides compounds of Formula (I): useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
    Type: Application
    Filed: August 7, 2019
    Publication date: December 22, 2022
    Inventors: Daniel S. Gardner, John V. Duncia, Joseph B. Santella, Khehyong Ngu, Christopher Annunziato
  • Indole and azaindole inhibitors of pad enzymes
    Patent number: 11524959
    Abstract: The present invention provides compounds of Formula (I) useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders, wherein each of Ring A, L, Q, R1, R2, R3, R4, R7, and R8 along with other variables are as defined herein.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: December 13, 2022
    Assignee: Bristol-Myers Squibb Company
    Inventors: Anurag S. Srivastava, Robert J. Cherney, Khehyong Ngu
  • BENZIMIDAZOLE INHIBITORS OF PAD ENZYMES
    Publication number: 20220348562
    Abstract: The present invention provides compounds of Formula (I): or a pharmaceutically acceptable salt thereof, useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders. Variables rings A, B, R1, R3, R8, and other variables are as defined herein.
    Type: Application
    Filed: August 7, 2019
    Publication date: November 3, 2022
    Inventor: Khehyong Ngu
  • INDOLE CARBOXAMIDE COMPOUNDS
    Publication number: 20210107891
    Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Application
    Filed: December 3, 2020
    Publication date: April 15, 2021
    Inventors: QINGJIE LIU, Scott Hunter Watterson, John E. Macor, Khehyong Ngu, Saleem Ahmad
  • Heterocyclic compounds useful as modulators of TNF alpha
    Patent number: 10865191
    Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: A is CR1 or N; B is CR3 or N; D is CR4 or N; L1 is —(CR7R7)m—; L2 is —(CR7R7)n—; and X, Z, R1, R2, R3, R4, R5, and R6 are define herein. Also disclosed are methods of using such compounds as modulators of TNF?, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: December 15, 2020
    Assignee: Bristol-Myers Squibb Company
    Inventors: Hai-Yun Xiao, T. G. Murali Dhar, Ning Li, Jingwu Duan, Bin Jiang, Zhonghui Lu, Khehyong Ngu, William J. Pitts, Joseph A. Tino
  • INDOLE CARBOXAMIDE COMPOUNDS
    Publication number: 20200165222
    Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Application
    Filed: January 28, 2020
    Publication date: May 28, 2020
    Inventors: Qingjie LIU, Scott Hunter Watterson, John E. Macor, Khehyong Ngu, Saleem Ahmad
  • Indole carboxamide compounds
    Patent number: 10604504
    Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: March 31, 2020
    Assignee: Bristol-Myers Squibb Company
    Inventors: Qingjie Liu, Scott Hunter Watterson, John E. Macor, Khehyong Ngu, Saleem Ahmad
  • INDOLE CARBOXAMIDE COMPOUNDS
    Publication number: 20190248760
    Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Application
    Filed: April 29, 2019
    Publication date: August 15, 2019
    Inventors: Qingjie LIU, Scott Hunter Watterson, John E. Macor, Khehyong Ngu, Saleem Ahmad
  • Indole carboxamide compounds
    Patent number: 10329274
    Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: June 25, 2019
    Assignee: Bristol-Myers Squibb Company
    Inventors: Qingjie Liu, Scott Hunter Watterson, John E. Macor, Khehyong Ngu, Saleem Ahmad
  • INDOLE CARBOXAMIDE COMPOUNDS
    Publication number: 20190119245
    Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Application
    Filed: February 1, 2018
    Publication date: April 25, 2019
    Inventors: Qingjie Liu, Scott Hunter Watterson, John E. Macor, Khehyong Ngu, Saleem Ahmad
  • HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF TNF ALPHA
    Publication number: 20180222883
    Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: A is CR1 or N; B is CR3 or N; D is CR4 or N; L1 is —(CR7R7)m—; L2 is —(CR7R7)n—; and X, Z, R1, R2, R3, R4, R5, and R6 are define herein. Also disclosed are methods of using such compounds as modulators of TNF?, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
    Type: Application
    Filed: August 2, 2016
    Publication date: August 9, 2018
    Inventors: Hai-Yun XIAO, Murali T.G. Dhar, Ning Li, Jingwu Duan, Bin Jiang, Zhonghui Lu, Khehyong Ngu, William J. Pitts, Joseph A. Tino
  • INDOLE CARBOXAMIDE COMPOUNDS
    Publication number: 20170260160
    Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Application
    Filed: May 30, 2017
    Publication date: September 14, 2017
    Inventors: Qingjie Liu, Scott Hunter Watterson, Douglas G. Batt, Saleem Ahmad, Myra Beaudoin Bertrand, Hua Gong, Weiwei Guo, John E. Macor, Khehyong Ngu, Andrew J. Tebben, Joseph A. Tino
  • INDOLE CARBOXAMIDE COMPOUNDS
    Publication number: 20160115126
    Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Application
    Filed: October 23, 2015
    Publication date: April 28, 2016
    Inventors: Qingjie Liu, Scott Hunter Watterson, Douglas G. Batt, Saleem Ahmad, Myra Beaudoin Bertrand, Hua Gong, Weiwei Guo, John E. Macor, Khehyong Ngu, Andrew J. Tebben, Joseph A. Tino