Patents by Inventor Khen Perlmutter
Khen Perlmutter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11938021Abstract: A prosthetic heart valve has a frame including a plurality of strut members, an inflow end, and an outflow end. A leaflet structure is situated at least partially within the frame, and a covering is disposed around an exterior of the frame. The covering includes a cushioning layer, and a first strip member folded over an inflow circumferential edge portion of the cushioning layer to form a first protective portion. A second strip member is folded over an outflow circumferential edge portion of the cushioning layer to form a second protective portion. The first strip member and the second strip member are spaced apart from each other along a longitudinal axis of the prosthetic heart valve.Type: GrantFiled: November 23, 2021Date of Patent: March 26, 2024Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Sara Tzadok, Khen Perlmutter, Darshin S. Patel, Boaz Manash, Ajay Chadha, Waina Michelle Chu, Chambory Chhe, Evan T. Schwartz, Sandip Vasant Pawar
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Patent number: 11801133Abstract: Docking devices for docking a prosthetic valve at a native valve of a heart can include a coiled docking anchor and a retrieval suture. The docking device and retrieval suture can be configured for improved retention and retrieval of the docking device after deployment. The docking devices can have an end portion with a central axis. The retrieval suture can be connected to the end portion such that a line of force applied by applying tension to the retrieval suture is substantially aligned with the central axis.Type: GrantFiled: July 20, 2020Date of Patent: October 31, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Darshin S. Patel, Boaz Manash, Khen Perlmutter, Eyal Leiba, Yoav Rozen, Dinesh L. Sirimanne, Tri D. Tran, Jocelyn Chau, Noa Axelrod Manela, Zohar Kiblitski
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Publication number: 20230310152Abstract: A docking device for docking a prosthetic valve at a native valve of a heart can include a coil comprising a plurality of turns and having a proximal end and distal end. The docking device can further include a first covering disposed around and covering the coil from the distal end to the proximal end of the coil, and a second covering disposed over the first covering. A distal end and proximal end of the second covering are spaced away from a distal end and proximal end, respectively, of the first covering.Type: ApplicationFiled: June 6, 2023Publication date: October 5, 2023Inventors: Darshin S. Patel, Boaz Manash, Khen Perlmutter, Eyal Leiba, Yoav Rozen, Dinesh L. Sirimanne, Tri D. Tran, Jocelyn Chau, Noa Axelrod Manela, Zohar Kiblitski
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Publication number: 20230201015Abstract: A docking station for a prosthetic heart valve includes a radially expandable and collapsible frame with a first plurality of struts, an inflow end portion, an outflow end portion, and a longitudinal axis. A sealing member is disposed on the outflow end portion and configured to form a seal between the docking station and a body lumen. The docking station further includes a valve seat coupled to the frame and configured to receive an expandable prosthetic valve. The valve seat includes a second plurality of struts coupled to the frame and extending in a downstream direction and angled inwardly toward the longitudinal axis of the frame.Type: ApplicationFiled: February 17, 2023Publication date: June 29, 2023Inventors: Nikolai Gurovich, Boaz Manash, Adi Carmi, Eran Goldberg, Khen Perlmutter
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Publication number: 20220287828Abstract: Anchoring or docking devices configured to be positioned at a native valve of a human heart and to provide structural support for docking a prosthetic valve therein. The docking devices can have coiled structures that define an inner space in which the prosthetic valve can be held. The docking devices can have enlarged end regions with circular or non-circular shapes, for example, to facilitate implantation of the docking device or to better hold the docking device in position once deployed. The docking devices can be laser-cut tubes with locking wires to assist in better maintaining a shape of the docking device. The docking devices can include various features to promote friction, such as frictional cover layers. Such docking devices can have ends configured to more securely attach the cover layers to cores of the docking devices.Type: ApplicationFiled: May 27, 2022Publication date: September 15, 2022Inventors: Darshin S. Patel, Boaz Manash, Khen Perlmutter, Yoav Rozen, Dinesh L. Sirimanne, Zohar Kiblitski, Noa Axelrod Manela
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Publication number: 20220257367Abstract: An implantable prosthetic valve can include a frame movable between a radially compressed and a radially expanded configuration. The frame can include a first strut having a first locking feature disposed on a radially facing inner surface of the strut and a second strut having a second locking feature disposed on a radially facing outer surface of the strut. The first and second locking features can engage each other so as to allow pivoting of the first and second struts relative to one another in a first direction upon radial expansion of the frame and resist pivoting of the first and second struts relative to one another in a second direction to resist radial compression of the frame.Type: ApplicationFiled: April 29, 2022Publication date: August 18, 2022Applicant: Edwards Lifesciences CorporationInventors: Yair A. Neumann, Oren Cohen, Khen Perlmutter, Eitan Atias, Noam Miller, Eran Goldberg, Anatoly Dvorsky, Tamir S. Levi, Haim Yushtein, Danny M. Garmahi, Ziv Yohanan, Michael Bukin, Noam Nir, Elena Sherman, Gideon Sagi
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Patent number: 11344407Abstract: Anchoring or docking devices configured to be positioned at a native valve of a human heart and to provide structural support for docking a prosthetic valve therein. The docking devices can have coiled structures that define an inner space in which the prosthetic valve can be held. The docking devices can have enlarged end regions with circular or non-circular shapes, for example, to facilitate implantation of the docking device or to better hold the docking device in position once deployed. The docking devices can be laser-cut tubes with locking wires to assist in better maintaining a shape of the docking device. The docking devices can include various features to promote friction, such as frictional cover layers. Such docking devices can have ends configured to more securely attach the cover layers to cores of the docking devices.Type: GrantFiled: November 4, 2019Date of Patent: May 31, 2022Assignee: Edwards Lifesciences CorporationInventors: Darshin S. Patel, Boaz Manash, Khen Perlmutter, Yoav Rozen, Dinesh L. Sirimanne, Zohar Kiblitski, Noa Axelrod
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Publication number: 20220110742Abstract: Various mechanically expandable prosthetic heart valves, as well as deliver apparatus, delivery assemblies, and methods for implanting such prosthetic heart valves. In one example, a prosthetic heart valve includes a mechanically expandable frame, a valve structure, and an actuator. The frame includes a plurality of struts and is movable between a radially compressed state and a radially expanded state. The valve structure includes a plurality of leaflets. The actuator is coupled to the frame and comprises an actuation lumen, a locking member, and a locking element. The actuation lumen is circumferentially spaced and axially parallel to the locking member. The actuation lumen is configured for receiving an axially movable actuation shaft that can move the frame between the radially compressed state and the radially expanded state. The locking element is rotatably coupled to the locking member and is configured to lock the frame at a desired state.Type: ApplicationFiled: December 20, 2021Publication date: April 14, 2022Applicant: Edwards Lifesciences CorporationInventors: Tamir S. Levi, Michael Bukin, Noam Nir, Ziv Yohanan, Elazar Levi Schwarcz, Oren Cohen, Ofir Witzman, Eitan Atias, Noam Miller, Khen Perlmutter, Boaz Manash, Eyal Leiba, Eran Goldberg
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Publication number: 20220079750Abstract: A prosthetic heart valve has a frame including a plurality of strut members, an inflow end, and an outflow end. A leaflet structure is situated at least partially within the frame, and a covering is disposed around an exterior of the frame. The covering includes a cushioning layer, and a first strip member folded over an inflow circumferential edge portion of the cushioning layer to form a first protective portion. A second strip member is folded over an outflow circumferential edge portion of the cushioning layer to form a second protective portion. The first strip member and the second strip member are spaced apart from each other along a longitudinal axis of the prosthetic heart valve.Type: ApplicationFiled: November 23, 2021Publication date: March 17, 2022Inventors: Sara Tzadok (formerly Haivatov), Khen Perlmutter, Darshin S. Patel, Boaz Manash, Ajay Chadha, Waina Michelle Chu, Chambory Chhe, Evan T. Schwartz, Sandip Vasant Pawar
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Patent number: 11185406Abstract: A prosthetic heart valve includes a frame having a plurality of strut members, an inflow end, and an outflow end. The prosthetic heart valve further includes a leaflet structure situated at least partially within the frame, and a covering disposed around the frame. The covering has a first layer and a second layer, wherein the second layer has a plush surface. The first layer is folded over a circumferential edge portion of the second layer to form a protective portion that extends beyond the strut members in a direction along a longitudinal axis of the prosthetic heart valve.Type: GrantFiled: January 19, 2018Date of Patent: November 30, 2021Assignee: Edwards Lifesciences CorporationInventors: Sara Haivatov, Khen Perlmutter, Darshin S. Patel, Boaz Manash, Ajay Chadha, Waina Michelle Chu, Chambory Chhe, Evan T. Schwartz, Sandip Vasant Pawar
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Publication number: 20210361417Abstract: A method of treating mitral valve stenosis in a human heart includes advancing a delivery apparatus through a right femoral vein, across a septal wall, and through a calcified mitral valve. A prosthetic heart valve is provided along a distal end portion of the delivery apparatus, wherein the prosthetic heart valve includes a metallic frame having a plurality of tissue-engaging elements positioned along an exterior surface and a leaflet structure for replacing the function of the calcified mitral valve. The prosthetic heart valve is radially expanded within an annulus of the calcified mitral valve such that at least some of the tissue-engaging elements of the prosthetic heart valve embed into the annulus. After radial expansion, the prosthetic heart valve is retained in position within the annulus via the tissue-engaging element and the leaflet structure replaces the function of the native mitral valve.Type: ApplicationFiled: August 9, 2021Publication date: November 25, 2021Applicant: Edwards Lifesciences CorporationInventors: Boaz Manash, Khen Perlmutter, Adi Carmi, Noa Axelrod Manela, Nikolay Gurovich
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Patent number: 11083571Abstract: A prosthetic heart valve is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. The heart valve includes an annular inner frame formed with a plurality of angled first strut members, the inner frame being configured to foreshorten from a first length corresponding to the collapsed configuration to a second length corresponding to the expanded configuration. A leaflet structure is situated at least partially within the inner frame. An outer frame is disposed radially outward of the inner frame and coupled to the inner frame. The outer frame is configured to collapse with the inner frame and radially expand with the inner frame, and includes a plurality of second strut members. Portions of the second strut members are configured to bend radially outwardly into a curved shape as the inner frame and the outer frame move from the collapsed configuration to the expanded configuration.Type: GrantFiled: June 14, 2019Date of Patent: August 10, 2021Assignee: Edwards Lifesciences CorporationInventors: Boaz Manash, Khen Perlmutter, Adi Carmi, Noa Axelrod, Nikolay Gurovich
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Publication number: 20200345492Abstract: Docking devices for docking a prosthetic valve at a native valve of a heart can include a coiled docking anchor and a retrieval suture. The docking device and retrieval suture can be configured for improved retention and retrieval of the docking device after deployment. The docking devices can have an end portion with a central axis. The retrieval suture can be connected to the end portion such that a line of force applied by applying tension to the retrieval suture is substantially aligned with the central axis.Type: ApplicationFiled: July 20, 2020Publication date: November 5, 2020Inventors: Darshin S. Patel, Boaz Manash, Khen Perlmutter, Eyal Leiba, Yoav Rozen, Dinesh L. Sirimanne, Tri D. Tran, Jocelyn Chau, Noa Axelrod Manela, Zohar Kiblitski
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Patent number: 10722359Abstract: Docking devices for docking a prosthetic valve at a native valve of a heart can include a coiled docking anchor and a retrieval suture. The docking device and retrieval suture can be configured for improved retention and retrieval of the docking device after deployment. The docking devices can have an end portion with a central axis. The retrieval suture can be connected to the end portion such that a line of force applied by applying tension to the retrieval suture is substantially aligned with the central axis.Type: GrantFiled: February 22, 2018Date of Patent: July 28, 2020Assignee: Edwards Lifesciences CorporationInventors: Darshin S. Patel, Boaz Manash, Khen Perlmutter, Eyal Leiba, Yoav Rozen, Dinesh L. Sirimanne, Tri D. Tran, Jocelyn Chau, Noa Axelrod, Zohar Kiblitski
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Publication number: 20200060811Abstract: Anchoring or docking devices configured to be positioned at a native valve of a human heart and to provide structural support for docking a prosthetic valve therein. The docking devices can have coiled structures that define an inner space in which the prosthetic valve can be held. The docking devices can have enlarged end regions with circular or non-circular shapes, for example, to facilitate implantation of the docking device or to better hold the docking device in position once deployed. The docking devices can be laser-cut tubes with locking wires to assist in better maintaining a shape of the docking device. The docking devices can include various features to promote friction, such as frictional cover layers. Such docking devices can have ends configured to more securely attach the cover layers to cores of the docking devices.Type: ApplicationFiled: November 4, 2019Publication date: February 27, 2020Inventors: Darshin S. Patel, Boaz Manash, Khen Perlmutter, Yoav Rozen, Dinesh L. Sirimanne, Zohar Kiblitski, Noa Axelrod
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Publication number: 20200000579Abstract: A prosthetic heart valve is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. The heart valve includes an annular inner frame formed with a plurality of angled first strut members, the inner frame being configured to foreshorten from a first length corresponding to the collapsed configuration to a second length corresponding to the expanded configuration. A leaflet structure is situated at least partially within the inner frame. An outer frame is disposed radially outward of the inner frame and coupled to the inner frame. The outer frame is configured to collapse with the inner frame and radially expand with the inner frame, and includes a plurality of second strut members. Portions of the second strut members are configured to bend radially outwardly into a curved shape as the inner frame and the outer frame move from the collapsed configuration to the expanded configuration.Type: ApplicationFiled: June 14, 2019Publication date: January 2, 2020Inventors: Boaz Manash, Khen Perlmutter, Adi Carmi, Noa Axelrod, Nikolay Gurovich
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Patent number: 10463479Abstract: Anchoring or docking devices configured to be positioned at a native valve of a human heart and to provide structural support for docking a prosthetic valve therein. The docking devices can have coiled structures that define an inner space in which the prosthetic valve can be held. The docking devices can have enlarged end regions with circular or non-circular shapes, for example, to facilitate implantation of the docking device or to better hold the docking device in position once deployed. The docking devices can be laser-cut tubes with locking wires to assist in better maintaining a shape of the docking device. The docking devices can include various features to promote friction, such as frictional cover layers. Such docking devices can have ends configured to more securely attach the cover layers to cores of the docking devices.Type: GrantFiled: August 21, 2017Date of Patent: November 5, 2019Assignee: Edwards Lifesciences CorporationInventors: Boaz Manash, Darshin S. Patel, Khen Perlmutter, Yoav Rozen, Dinesh L. Sirimanne, Zohar Kiblitski, Noa Axelrod
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Publication number: 20180206982Abstract: A prosthetic heart valve includes a frame having a plurality of strut members, an inflow end, and an outflow end. The prosthetic heart valve further includes a leaflet structure situated at least partially within the frame, and a covering disposed around the frame. The covering has a first layer and a second layer, wherein the second layer has a plush surface. The first layer is folded over a circumferential edge portion of the second layer to form a protective portion that extends beyond the strut members in a direction along a longitudinal axis of the prosthetic heart valve.Type: ApplicationFiled: January 19, 2018Publication date: July 26, 2018Inventors: Sara Haivatov, Khen Perlmutter, Darshin S. Patel, Boaz Manash, Ajay Chadha, Waina Michelle Chu, Chambory Chhe, Evan T. Schwartz, Sandip Vasant Pawar
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Publication number: 20180177594Abstract: Docking devices for docking a prosthetic valve at a native valve of a heart can include a coiled docking anchor and a retrieval suture. The docking device and retrieval suture can be configured for improved retention and retrieval of the docking device after deployment. The docking devices can have an end portion with a central axis. The retrieval suture can be connected to the end portion such that a line of force applied by applying tension to the retrieval suture is substantially aligned with the central axis.Type: ApplicationFiled: February 22, 2018Publication date: June 28, 2018Inventors: Darshin S. Patel, Boaz Manash, Khen Perlmutter, Eyal Leiba, Yoav Rozen, Dinesh L. Sirimanne, Tri D. Tran, Jocelyn Chau, Noa Axelrod, Zohar Kiblitski
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Patent number: D890333Type: GrantFiled: February 2, 2018Date of Patent: July 14, 2020Assignee: Edwards Lifesciences CorporationInventors: Darshin S. Patel, Boaz Manash, Khen Perlmutter, Noa Axelrod