Patents by Inventor Khew-Voon Chin

Khew-Voon Chin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small Molecule Intervention for Obesity
    Publication number: 20100284925
    Abstract: Methods and compositions for activating PLTP gene expression include administering an effective amount of a limonoid.
    Type: Application
    Filed: October 17, 2007
    Publication date: November 11, 2010
    Inventor: Khew-Voon Chin
  • Nucleic acid and protein expression thereby and their involvement in stress
    Patent number: 7214771
    Abstract: The present invention pertains to a novel BTB-POZ domain zinc finger protein, which is named herein RI?-associated zinc finger (RIAZ). The nucleic acid and corresponding protein products have been identified, as have numerous diagnostic and therapeutic utilities predicated on the observed role that the factors play as mediators of the progression of several cancers, and the host response to multiple stress. We have cloned and sequenced the full length cDNA of the gene expressing this protein. We demonstrate that in vitro synthesized RIAZ protein interacts with RI?. We hypothesize that the interaction of RI? with RIAZ may regulate apoptosis, cell growth and drug resistance. The factors of the invention are also believed to play a role in host chemosensitivity to cancer drugs, and the invention extends to the modulation of the factors to treat conditions reflective of abnormal levels thereof.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: May 8, 2007
    Assignee: University of Medicine & Dentistry of New Jersey
    Inventor: Khew-Voon Chin
  • Phospholipid transfer protein (PLTP) and cholesterol metabolism
    Publication number: 20060252787
    Abstract: A method for controlling cholesterol metabolism in a host, a screening assay for agents that can control cholesterol metabolism, and the agents that may be identified are practiced and determined in relation to the expression of PLTP in HepG2 cells and a clone from these cells, designated HepG2/PLTPpLuc. Particular agents that are covered comprise camptothecin, topotecan, derivatives thereof, metabolic byproducts thereof and small molecule mimics thereof.
    Type: Application
    Filed: July 17, 2006
    Publication date: November 9, 2006
    Inventor: Khew-Voon Chin
  • Phospholipid transfer protein (PLTP) and cholestoral metabolism
    Patent number: 7078411
    Abstract: A method for controlling cholesterol metabolism in a host, a screening assay for agents that can control cholesterol metabolism, and the agents that may be identified are practiced and determined in relation to the expression of PLTP in HepG2 cells and a clone from these cells, designated HepG2/PLTPpLuc. Particular agents that are covered comprise camptothecin, topotecan, derivatives thereof, metabolic byproducts thereof and small molecule mimics thereof.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: July 18, 2006
    Assignee: UMDNJ (Univ of Medicine & Dentist. of NJ)
    Inventor: Khew-Voon Chin
  • Nucleic acid and protein expressed thereby and their involvement in stress
    Publication number: 20030012776
    Abstract: The present invention pertains to a novel BTB-POZ domain zinc finger protein, which is named herein RI&agr;-associated zinc finger (RIAZ). The nucleic acid and corresponding protein products have been identified, as have numerous diagnostic and therapeutic utilities predicated on the observed role that the factors play as mediators of the progression of several cancers, and the host response to multiple stress. We have cloned and sequenced the full length cDNA of the gene expressing this protein. We demonstrate that in vitro synthesized RIAZ protein interacts with RI&agr;. We hypothesize that the interaction of RI&agr; with RIAZ may regulate apoptosis, cell growth and drug resistance. The factors of the invention are also believed to play a role in host chemosensitivity to cancer drugs, and the invention extends to the modulation of the factors to treat conditions reflective of abnormal levels thereof.
    Type: Application
    Filed: June 6, 2002
    Publication date: January 16, 2003
    Inventor: Khew-Voon Chin
  • Phospholipid transfer protein (PLTP) and cholesterol metabolism
    Publication number: 20020187997
    Abstract: A method for controlling cholesterol metabolism in a host, a screening assay for agents that can control cholesterol metabolism, and the agents that may be identified are practiced and determined in relation to the expression of PLTP in HepG2 cells and a clone from these cells, designated HepG2/PLTPpLuc. Particular agents that are covered comprise camptothecin, topotecan, derivatives thereof, metabolic byproducts thereof and small molecule mimics thereof.
    Type: Application
    Filed: May 15, 2002
    Publication date: December 12, 2002
    Inventor: Khew-Voon Chin