Abstract: The novel chlorinated sugar O-.alpha.-D-6-chloro-6-deoxygalactopyranosyl-(1.fwdarw.6)-.alpha.-D-4-chlo ro-4-deoxygalactopyranosyl-(1.fwdarw.2)-.beta.-D-1, 6-dichloro-1, 6-dideoxyfructofuranoside (TCR) can be used to prepare sucralose by incubating the TCR in solution in the presence of an enzyme serving to remove the 6-chloro-6-deoxygalactosyl moiety from the 6-position, especially an enzyme derived from a strain of Mortierella vinacea, Circinella muscae or Aspergillus niger. TCR is prepared by treating raffinose with thionyl chloride in the presence of triphenylphosphine oxide.

Abstract: A process for the preparation of 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose (TGS) comprising the steps of:(a) reacting sucrose with an acylating reagent under conditions to provide a mixture of acylated sucrose derivatives containing a major proportion of 6-monoacylated material;(b) optionally separating 6-monoacylated sucrose derivative from other acylated derivatives before step (c);(c) reacting the monoacylated sucrose derivative with a chlorinating reagent capable of chlorinating at positions 1', 4 and 6' of a sucrose 6- acylate; and(d) deacylating and separating (in either order) the 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose material formed.

Abstract: A novel cyclic acetal derivative of sucrose, 4,6-O-isopropylidenesucrose, is prepared by treating sucrose with 2,2-dimethoxypropane in N,N-dimethylformamide, in the presence of p-toluenesulphonic acid, suitably at room temperature. The product is conveniently isolated in the form of its hexa-acetate or hexabenzoate, by treatment with acetic anhydride or benzoyl chloride, respectively, in pyridine. The resulting compounds are valuable as synthetic intermediates and in conformational investigations.