Patents by Inventor Ki-byung Chai

Ki-byung Chai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C7 acyloxy metal alkoxides
    Patent number: 6762309
    Abstract: Taxane derivatives having alternative C7 substituents.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: July 13, 2004
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai
  • Beta-lactams having an alkyl-substituted side chain
    Publication number: 20030187061
    Abstract: Taxane derivatives having an alkyl substituted C13 side chain.
    Type: Application
    Filed: January 27, 2003
    Publication date: October 2, 2003
    Applicant: Florida State University
    Inventors: Robert A. Holton, Ki-Byung Chai, Hamid Idmoumaz, Hossain Nadizadeh, Yukio Suzuki
  • C9 hydrido, hydroxy and acyloxy metal alkoxides
    Publication number: 20030114419
    Abstract: Taxane derivatives having alternative C9 substituents.
    Type: Application
    Filed: November 18, 2002
    Publication date: June 19, 2003
    Applicant: Florida State University
    Inventors: Robert A. Holton, Ki-Byung Chai, Yukio Suzuki
  • C10 OXO and hydrido taxane derivatives and pharmaceutical compositions containing them
    Patent number: 6552205
    Abstract: Taxane derivatives having alternative C10 substituents.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: April 22, 2003
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai
  • Taxanes having T-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
    Publication number: 20030065200
    Abstract: Taxane derivatives having an alkoxy, alkenoxy or aryloxy substituted C13 side chain.
    Type: Application
    Filed: September 17, 2002
    Publication date: April 3, 2003
    Applicant: Florida State University
    Inventors: Robert A. Holton, Ki-Byung Chai, Hamid Idmoumaz, Hossain Nadizadeh, Kasthuri Rengan, Yukio Suzuki, Chunlin Tao
  • C7 ACYLOXY METAL ALKOXIDES
    Publication number: 20030055272
    Abstract: Taxane derivatives having alternative C7 substituents.
    Type: Application
    Filed: September 20, 2002
    Publication date: March 20, 2003
    Applicant: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai
  • Butenyl substituted taxanes
    Publication number: 20030045531
    Abstract: Taxane derivatives having a 3′ butenyl substituted C13 side chain.
    Type: Application
    Filed: March 29, 2002
    Publication date: March 6, 2003
    Applicant: Florida State University
    Inventors: Robert A. Holton, Ki-Byung Chai, Hossain Nadizadeh
  • 3?-alkyl substituted taxanes and pharmaceutical compositions containing them
    Patent number: 6521660
    Abstract: Taxane derivatives having an alkyl substituted C13 side chain.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: February 18, 2003
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-Byung Chai, Hamid Idmoumaz, Hossain Nadizadeh, Yukio Suzuki
  • C9 hydrido, hydroxy and acyloxy taxane derivatives and pharmaceutical compositions containing them
    Patent number: 6482963
    Abstract: Taxane derivatives having alternative C9 substituents.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: November 19, 2002
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai, Yukio Suzuki
  • Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
    Publication number: 20020147335
    Abstract: Taxane derivatives having an alkyl substituted C13 side chain.
    Type: Application
    Filed: April 29, 2002
    Publication date: October 10, 2002
    Applicant: Florida State University
    Inventors: Robert A. Holton, Ki-Byung Chai, Hamid Idmoumaz, Hossain Nadizadeh, Yukio Suzuki
  • C7 acyloxy and hydrido taxane derivatives and pharmaceutical compositions containing them
    Patent number: 6462208
    Abstract: Taxane derivatives having alternative C7 substituents.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: October 8, 2002
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-Byung Chai
  • Butenyl substituted &bgr;-lactams
    Patent number: 6395895
    Abstract: Taxane derivatives having a 3′ butenyl substituted C13 side chain.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: May 28, 2002
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai, Hossain Nadizadeh
  • C7 TAXANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20020002292
    Abstract: Taxane derivatives having alternative C7 substituents.
    Type: Application
    Filed: October 25, 1999
    Publication date: January 3, 2002
    Inventors: ROBERT A. HOLTON, KI-BYUNG CHAI
  • Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
    Patent number: 6335362
    Abstract: Taxane derivatives having an alkyl substituted C13 side chain.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 1, 2002
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai, Hamid Idmoumaz, Hossain Nabizadeh, Yukio Suzuki
  • Process for preparing paclitaxel
    Patent number: 6130336
    Abstract: The present invention elates to a process for preparing paclitaxel represented by formula (1) characterized in that: (a) an oxazolidine derivative represented by formula (2) or its salt in which X represents halogen, is coupled with a 7-trihaloacetyl-baccatin III represented by formula (3) in which R.sub.1 represents trihaloacetyl, in a solvent in the presence of a condensing agent to produce an oxazolidine substituent-containing taxane represented by formula (4) in which X and R.sub.1 are each as previously defined; (b) the oxazolidine ring is opened in a solvent in the presence of an acid, and the product thus obtained is reacted with benzoyl chloride in the presence of a base to produce a protected paclitaxel wherein the hydroxy group at 7-position is protected with trihaloacetyl group represented by formula (5) in which R.sub.1 is as previously defined; (c) then the protecting group at 7-position is removed by ammonia or a salt of ammonia with a weak acid in a solvent.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: October 10, 2000
    Assignee: Hanmi Pharm., Co. Ltd.
    Inventors: Kyoung Soo Kim, Ki Byung Chai, Young Ho Moon, Kwang Ok Lee, Nam Du Kim, Tae Hee Ha, Jung Ae Shin, Gwan Sun Lee, Wan Joo Kim
  • Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
    Patent number: 6018073
    Abstract: Taxane derivatives having an alkoxy, alkenoxy or aryloxy substituted C13 side chain.
    Type: Grant
    Filed: December 17, 1997
    Date of Patent: January 25, 2000
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai, Hamid Idmoumaz, Hossain Nadizadeh, Kasthuri Rengan, Yukio Suzuki, Chunlin Tao
  • C9 taxane derivatives and pharmaceutical compositions containing them
    Patent number: 6011056
    Abstract: Taxane derivatives having alternative C9 substituents.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 4, 2000
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai, Yukio Suzuki
  • Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
    Patent number: 6005138
    Abstract: Taxane derivatives having a 3' butenyl substituted C13 side chain.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: December 21, 1999
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai, Hossain Nadizadeh
  • C10 tricyclic taxanes
    Patent number: 5998656
    Abstract: Taxane derivatives having alternative C10 substituents.
    Type: Grant
    Filed: December 4, 1997
    Date of Patent: December 7, 1999
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai
  • C7 tricyclic taxanes
    Patent number: 5994576
    Abstract: Taxane derivatives having alternative C7 substituents.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: November 30, 1999
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai