Abstract: The invention provides novel substituted heterocyclic compounds represented by Formula I and Formula II, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans.

Abstract: The invention provides novel substituted heterocyclic compounds represented by Formula I and Formula II, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans.

Abstract: The present invention provides for a composition capable of storing hydrogen from molecular hydrogen. The composition comprises a magnesium nanoparticle (NP) and a polymer, wherein the Mg NC is essentially embedded in the polymer. The polymer is selectively permeable wherein the polymer is essentially not permeable to O2 and H2O. The composition is capable of absorbing and desorbing molecular hydrogen.

Abstract: According to one embodiment, a ball mill for working generally spherically shaped target particles into a flake-shaped end product is provided. The ball mill includes a milling tube, one or more milling balls disposed within the milling tube, and a vibration source that is positioned and adapted to move the milling tube such that its central axis follows along a substantially circular path. The continuously changing direction of the acceleration of the milling tube results in each of the milling balls following a respective, substantially orbital path about the milling tube's central axis. As the milling balls follow the respective, orbital paths, the milling balls come into contact with and transform the target particles into flakes. In a further embodiment, the ball mill may further include a virtual particle separator configured to route intermediate particles back to an inlet portion of the milling tube for additional processing time.