Abstract: A system to assess risk of changes to brain white matter includes a sensor system adapted to measure an energy of each impact to an individual belonging to a sub-population that causes a repetitive head impact (RHI). A head impact dose equivalent number (HIDEN) process calculates a HIDEN for a most recent RHI event based on the energy of the most recent RHI event, a time of the most recent RHI, and all previously recorded RHI events available in a non-volatile memory. A sub-population function process calculates a risk assessment number based on the sub-population and the HIDEN. A risk assessment notification means provides a notification of the risk assessment number. A method to assess risk of changes to brain white matter based on a head impact dose equivalent number and a method to define a sub-population function to convert a HIDEN to a risk assessment value is also described.

Abstract: A system to assess risk of changes to brain white matter includes a sensor system adapted to measure an energy of each impact to an individual belonging to a sub-population that causes a repetitive head impact (RHI). A head impact dose equivalent number (HIDEN) process calculates a HIDEN for a most recent RHI event based on the energy of the most recent RHI event, a time of the most recent RHI, and all previously recorded RHI events available in a non-volatile memory. A sub-population function process calculates a risk assessment number based on the sub-population and the HIDEN. A risk assessment notification means provides a notification of the risk assessment number. A method to assess risk of changes to brain white matter based on a head impact dose equivalent number and a method to define a sub-population function to convert a HIDEN to a risk assessment value is also described.

Abstract: Described herein are compositions and methods relating to biomarkers used to diagnose brain injury in a subject who has experienced a head trauma. The biomarkers described herein can be used to diagnose, monitor the onset, monitor the progression, and assess the recovery of brain injury. The biomarkers can also be used to establish and evaluate treatment plans.