Abstract: Systems and methods of providing push-to-application services are provided. A network includes a push-to-application session controller that manages a push-to-application session between an application and a client. The network also includes a media controller, coupled to the session controller, that transfers media between the client and the application. The network further includes an application synchronizer, coupled to the session controller, that controls synchronization between media provided by the media controller to the client and data provided by the application to the client.

Abstract: In a method for managing a target system from a Push-to-Talk station, a Gateway receives a request to manage the target system from the Push-to-Talk station. The request includes an identifier for the Push-to-Talk station and an identifier for the target system. A push-to-talk call session is established between the Push-to-Talk station and the Gateway. A second communication session is established between the target system and the Gateway using an appropriate protocol supported by the target system. The Gateway Transformer translates messages from the Push-to-Talk station into formats and protocols registered for use with the Push-to-Talk station for controlling and querying the target system.

Abstract: A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.