Abstract: There is described a Layer 3 router and method for routing PRP frames. A first frame is received at one or more ports of the Layer 3 router. A PRP suffix of the first frame, a source MAC address of the first frame, and a Redundancy Control Trailer of the first frame are identified. The first frame is forwarded to a routing subsystem of the Layer 3 router, and a second frame including a source IP address is received from the routing subsystem. The source MAC address of the first frame is assigned to the second frame in response to associating the source IP address with the source MAC address, and the Redundancy Control Trailer is appended to the second frame. The second frame is transmitted from the port or ports of the Layer 3 router.

Abstract: Systems and methods for cell culturing are disclosed herein. A fluidic exchange system for cell culturing comprises a cell culture cassette, comprising: a cell culture chamber having a cell culture and fluid media; and one or more pluggable ports fluidically connected to the cell culture chamber; a fluid media cassette, comprising: one or more liquid storage compartments; and one or more pluggable ports fluidically connected to the one or more liquid storage compartments; and a cassette coupler configured to fluidically couple the cell culture cassette and the fluid media cassette.

Abstract: Systems and methods are disclosed for enabling optical bioprocesses in cell manufacturing. A cell manufacturing platform comprises a cell culture cassette supporting a cell culture; an optical engine configured to: capture images of the cell culture; and optically remove cells from the cell culture; and wherein the cell culture cassette remains stationary and the optical engine moves relative to the cell culture cassette to capture the images and to remove cells.

Abstract: A method for cell culture expansion and maintenance, comprising seeding, in a first cell culture cassette, a plurality of cell colonies adhered to a first surface of the first cell culture cassette; capturing, by an optical engine, time-series images of the plurality of cell colonies as the plurality of cell colonies expand; determining, by a platform manager, a subset of cell colonies to remove from the first surface based on the time-series images; removing, by the optical engine, the subset of cell colonies from the first surface; washing, by a fluid management system, the removed subset of cell colonies from the first cell culture cassette; repeating steps for one or more iterations; harvesting a set of remaining cell colonies from the first cell culture cassette; seeding the set of remaining cell colonies into a second cell culture cassette; repeating steps for additional iterations in the second cell culture cassette.

Abstract: There is described a Layer 3 router and method for routing PRP frames. A first frame is received at one or more ports of the Layer 3 router. A PRP suffix of the first frame, a source MAC address of the first frame, and a Redundancy Control Trailer of the first frame are identified. The first frame is forwarded to a routing subsystem of the Layer 3 router, and a second frame including a source IP address is received from the routing subsystem. The source MAC address of the first frame is assigned to the second frame in response to associating the source IP address with the source MAC address, and the Redundancy Control Trailer is appended to the second frame. The second frame is transmitted from the port or ports of the Layer 3 router.

Abstract: Aperlinergic macrocyclic compounds are provided. In particular, a compound of formula (II): or a stereoisomer or a mixture thereof, or a pharmaceutically acceptable salt, ester or solvate thereof is provided. Also provided is a method of using aperlinergic macrocyclic compounds of the disclosure for treating a cardiovascular disease in a subject in need thereof, comprising administering an effective amount of the compound to the subject.

Abstract: A drilling fluid management system may receive a measurement of measured drilling fluid properties for a drilling fluid. A drilling fluid management system may compare the measurement of the measured drilling fluid properties to setpoint drilling fluid properties to generate a difference between the measurement and the setpoint drilling fluid properties. A drilling fluid management system may, based at least in part on the difference between the measurement and the setpoint drilling fluid properties, prep are a recommendation to return the drilling fluid to the setpoint drilling fluid properties.