Patents by Inventor Kieran Clarke

Kieran Clarke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150164855
    Abstract: Ketone bodies and ketone body esters maintain or improve muscle power output upon oral administration. Certain esters of hydroxybutyrate monomers are organoleptically acceptable and have high levels of uptake from the gut to the blood thereby allowing a rapid increase of blood concentration of hydroxybutyrate and beneficial physiological response including improved power output during exercise. Compositions containing the ketone bodies or ketone body esters are also described.
    Type: Application
    Filed: April 5, 2013
    Publication date: June 18, 2015
    Applicant: TDELTAS LIMITED
    Inventors: Kieran Clarke, Peter Cox
  • Patent number: 9034613
    Abstract: A process for producing a compound which is (3R)-hydroxybutyl (3R)-hydroxybutyrate of formula (I) which process comprises submitting, to enantioselective reduction, a compound of the following formula (II), (III) or (IV).
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: May 19, 2015
    Assignees: ISIS Innovation Limited, The United States of America, as Represented by the Secretary, Department of Health & Human Services
    Inventors: Jeremy Robertson, Kieran Clarke, Richard Lewis Veech
  • Publication number: 20150065571
    Abstract: Use of a ketone body and a ketone body ester for preserving glycogen and/or protein, thereby reducing muscle breakdown and improving endurance during exercise and promoting muscle recovery following exercise. Also for retarding muscle wasting in aging and disease. (R)-3-hydroxybutyl (R)-3-hydroxybutyrate for use in reducing muscle glycogen and protein breakdown during exercise or decreasing muscle wasting in aging and disease. Certain esters of hydroxybutyrate monomers, particularly a monoester of D-?-hydroxybutyrate with R-1,3-butanediol or with glycerol to reduce muscle breakdown and aid muscle recovery after exercise or retard muscle wasting. Compositions containing the ketone bodies or ketone body esters are also described.
    Type: Application
    Filed: August 7, 2014
    Publication date: March 5, 2015
    Applicant: TDELTAS LIMITED
    Inventors: Kieran Clarke, Peter Cox
  • Publication number: 20140308719
    Abstract: Embodiments of the present invention are directed to processes for the production of (R)-3-hydroxybutyl (R)-3-hydroxybyrate. Poly (R)-3-hydroxybyrate is transesterified with an alcohol, to form a first ester portion and a second ester portion. The first ester portion is reduced to the diol to form a diol portion and the diol portion is reacted with the second ester portion to produce (R)-3-hydroxybutyl (R)-3-hydroxybyrate.
    Type: Application
    Filed: March 14, 2014
    Publication date: October 16, 2014
    Inventors: Kieran Clarke, Richard Lewis Veech, M. Todd King
  • Publication number: 20140194509
    Abstract: A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3R)-hydroxybutyl (3R)-hydroxybutyrate of formula (I) is an effective and palatable precursor to the ketone body (3R)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of neurodegeneration, free radical toxicity, hypoxic conditions or hyperglycaemia.
    Type: Application
    Filed: December 10, 2013
    Publication date: July 10, 2014
    Applicants: Government of the USA, as Represented by the Secretary, Department of Health and Human Services, Isis Innovation Limited
    Inventors: Kieran Clarke, Richard Lewis Veech
  • Patent number: 8642654
    Abstract: A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3R)-hydroxybutyl (3R)-hydroxybutyrate of formula (I) is an effective and palatable precursor to the ketone body (3R)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of neurodegeneration, free radical toxicity, hypoxic conditions or hyperglycaemia.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: February 4, 2014
    Assignees: ISIS Innovation Limited, Government of the USA, as Represented by the Sec-Retary, Department of Health and Human Services
    Inventors: Kieran Clarke, Richard Lewis Veech
  • Publication number: 20130102663
    Abstract: An organoleptically acceptable composition containing a ketone body or a ketone body precursor including a hydroxybutyrate ester and a flavouring is provided and gives improved palatability and user adherence to the intended dose regime. The flavouring may be a bitter flavouring and the composition may further contain an adsorbent for the ketone such that on ingestion, the bitterness of the composition may be masked. The composition may be in the form of a solid, gel or liquid and provides increased blood ketone levels and may be used in therapy or in treating muscle impairment or fatigue.
    Type: Application
    Filed: February 22, 2011
    Publication date: April 25, 2013
    Applicant: TDELTAS LIMITED
    Inventor: Kieran Clarke
  • Publication number: 20120064611
    Abstract: A process for producing a compound which is (3R)-hydroxybutyl(3R)-hydroxybutyrate of formula (I) which process comprises submitting, to enantioselective reduction, a compound of the following formula (II), (III) or (IV).
    Type: Application
    Filed: April 16, 2009
    Publication date: March 15, 2012
    Inventors: Jeremy Robertson, Kieran Clarke, Richard Lewis Veech
  • Publication number: 20110237666
    Abstract: A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3R)-hydroxybutyl (3R)-hydroxybutyrate of formula (I) is an effective and palatable precursor to the ketone body (3R)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of neurodegeneration, free radical toxicity, hypoxic conditions or hyperglycaemia.
    Type: Application
    Filed: February 18, 2011
    Publication date: September 29, 2011
    Applicants: Isis Innovation Limited, Human Services
    Inventors: Kieran Clarke, Richard Lewis Veech
  • Publication number: 20110033387
    Abstract: The invention relates to a method of determination of PDH activity by 13C-MR detection using an imaging medium which comprises hyperpolarised 13C-pyruvate and to imaging media for use in said method.
    Type: Application
    Filed: September 5, 2008
    Publication date: February 10, 2011
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Marie A. Schroeder, Lowri E. Cochlin, Helen J. Atherton, Lisa C. Heather, Kieran Clarke, George K. Radda, Damian J. Tyler
  • Publication number: 20060078596
    Abstract: The present invention involves the use of a compound that reduces the level of free fatty acids circulating in the plasma of a subject in the manufacture of a medicament for the treatment of prevention of muscle (particularly cardiac or skeletal muscle) impairment or fatigue.
    Type: Application
    Filed: November 28, 2005
    Publication date: April 13, 2006
    Inventors: Kieran Clarke, Michaela Scheuermann-Freestone, Andrew Murray