Patents by Inventor Kieran Curran
Kieran Curran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230356227Abstract: A system for processing a biological sample can include a droplet generation assembly comprising a plurality of first reservoirs configured to contain an aqueous sample and a plurality of second reservoirs configured to contain a carrier fluid immiscible with the aqueous sample. The plurality of first reservoirs and the plurality of second reservoirs can be arranged to be in respective flow communication in pairs of reservoirs comprising a first reservoir of the plurality of first reservoirs and a second reservoir of the plurality of second reservoirs constituting a plurality of pairs of reservoirs. The droplet generation assembly can further include a flow control system configured to control a pressure in the plurality of pairs of reservoirs so as to generate a flow of a series of volumes of the aqueous sample separated by the carrier fluid. The system can further include a thermocycling system.Type: ApplicationFiled: May 4, 2023Publication date: November 9, 2023Applicant: STOKES BIO LIMITEDInventors: Mark Davies, Tara Dalton, Kieran Curran
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Patent number: 11772096Abstract: A system for processing a biological sample includes a substrate comprising a plurality of wells and a plurality of flow channels. The system further includes a flow control system comprising a manifold having a plurality of ports configured to fluidically couple to the plurality of wells, and one or more containment structures configured to contain carrier fluid and fluidically couple to the ports. The flow control system further includes a cradle configured to removably receive the substrate. The flow control system is configured to transmit pressure differential, via the manifold, to the plurality of wells so as to cause a plurality of sample volumes held by at least some wells of the plurality of wells to flow through respective flow channels and cause the carrier fluid to flow through the flow channels and form a plurality of droplets of the plurality of sample volumes separated by the carrier fluid.Type: GrantFiled: July 7, 2020Date of Patent: October 3, 2023Assignee: STOKES BIO LTD.Inventors: Mark Davies, Tara Dalton, Kieran Curran
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Patent number: 11684871Abstract: Assemblies, systems, and methods for isolation of target material are provided. In various embodiments, an assembly for target material isolation includes a housing having an upper portion and a lower portion together defining an inner chamber. The inner chamber includes a semi-toroidal shape and the semi-toroidal shape defines a longitudinal axis. The assembly further includes one or more fluidic connection from the exterior of the housing to the inner chamber. An isolation material (e.g., polymer wool and/or magnetic beads) may be disposed within the inner chamber. A system includes a configured to fit at least a portion of the housing and releasably couple the assembly. Upon activation of the motor, the assembly may rotate about the longitudinal axis. An angle of the platform may be adjustable to thereby change the angle of the longitudinal axis about which the assembly rotates.Type: GrantFiled: April 6, 2021Date of Patent: June 27, 2023Assignee: AnuCell Biosystems LimitedInventors: John Daly, Kieran Curran, Macdara Glynn, Mark McCabe, David Merrigan, Jason Ryan, John P. Griffin, Caitriona Ryan, Martin Reddin
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Publication number: 20210370288Abstract: Described herein are purge swab apparatuses, purge swabs kits, and methods for collecting a sample using a purge swab. In various embodiments, a purge swab includes an elongated body having a proximal end, a distal end, and a length therebetween. The purge swab further includes a swab head having a proximal end and a distal end wherein the proximal end of the swab head is attached to the distal end of the elongated body and the swab head includes a plurality of openings. The purge swab optionally includes a lumen extending from the proximal or distal end of the elongated body into at least a portion of the swab head, and the lumen is in fluidic communication with the plurality of openings.Type: ApplicationFiled: May 27, 2021Publication date: December 2, 2021Inventors: John Daly, Kieran Curran, Macdara Glynn, David Merrigan, Jason Ryan
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Publication number: 20210228999Abstract: Assemblies, systems, and methods for isolation of target material are provided. In various embodiments, an assembly for target material isolation includes a housing having an upper portion and a lower portion together defining an inner chamber. The inner chamber includes a semi-toroidal shape and the semi-toroidal shape defines a longitudinal axis. The assembly further includes one or more fluidic connection from the exterior of the housing to the inner chamber. An isolation material (e.g., polymer wool and/or magnetic beads) may be disposed within the inner chamber. A system includes a configured to fit at least a portion of the housing and releasably couple the assembly. Upon activation of the motor, the assembly may rotate about the longitudinal axis. An angle of the platform may be adjustable to thereby change the angle of the longitudinal axis about which the assembly rotates.Type: ApplicationFiled: April 6, 2021Publication date: July 29, 2021Inventors: John Daly, Kieran Curran, Macdara Glynn, Mark McCabe, David Merrigan, Jason Ryan, John P. Griffin, Caitriona Ryan, Martin Reddin
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Patent number: 11000780Abstract: Assemblies, systems, and methods for isolation of target material are provided. In various embodiments, an assembly for target material isolation includes a housing having an upper portion and a lower potion together defining an inner chamber. The inner chamber includes a semi-toroidal shape and the semi-toroidal shape defines a longitudinal axis. The assembly further includes one or more fluidic connection from the exterior of the housing to the inner chamber. An isolation material (e.g., polymer wool and/or magnetic beads) may be disposed within the inner chamber. A system includes a configured to fit at least a portion of the housing and releasably couple the assembly. Upon activation of the motor, the assembly may rotate about the longitudinal axis. An angle of the platform may be adjustable to thereby change the angle of the longitudinal axis about which the assembly rotates.Type: GrantFiled: December 6, 2019Date of Patent: May 11, 2021Assignee: AnuCell Biosystems LimitedInventors: John Daly, Kieran Curran, Macdara Glynn, Mark McCabe, David Merrigan, Jason Ryan, John P. Griffin, Caitriona Ryan, Martin Reddin
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Publication number: 20210023561Abstract: A bridge (30) comprises a first inlet port (31) at the end of a capillary, a narrower second inlet port (32) which is an end of a capillary, an outlet port (33) which is an end of a capillary, and a chamber (34) for silicone oil. The oil is density-matched with the reactor droplets such that a neutrally buoyant environment is created within the chamber (34). The oil within the chamber is continuously replenished by the oil separating the reactor droplets. This causes the droplets to assume a stable capillary-suspended spherical form upon entering the chamber (34). The spherical shape grows until large enough to span the gap between the ports, forming an axisym metric liquid bridge. The introduction of a second droplet from the second inlet port (32) causes the formation of an unstable funicular bridge that quickly ruptures from the, finer, second inlet port (32), and the droplets combine at the liquid bridge (30).Type: ApplicationFiled: July 7, 2020Publication date: January 28, 2021Applicant: STOKES BIO LTD.Inventors: Mark DAVIES, Tara DALTON, Kieran CURRAN
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Patent number: 10730051Abstract: A bridge (30) comprises a first inlet port (31) at the end of a capillary, a narrower second inlet port (32) which is an end of a capillary, an outlet port (33) which is an end of a capillary, and a chamber (34) for silicone oil. The oil is density-matched with the reactor droplets such that a neutrally buoyant environment is created within the chamber (34). The oil within the chamber is continuously replenished by the oil separating the reactor droplets. This causes the droplets to assume a stable capillary-suspended spherical form upon entering the chamber (34). The spherical shape grows until large enough to span the gap between the ports, forming an axisymmetric liquid bridge. The introduction of a second droplet from the second inlet port (32) causes the formation of an unstable funicular bridge that quickly ruptures from the, finer, second inlet port (32), and the droplets combine at the liquid bridge (30).Type: GrantFiled: April 18, 2016Date of Patent: August 4, 2020Assignee: STOKES BIO LTD.Inventors: Mark Davies, Tara Dalton, Kieran Curran
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Patent number: 10513729Abstract: Provided herein is a biological detection system and method of use wherein the biological detection system comprises at least one mixer or liquid bridge for combining at least two liquid droplets and an error correction system for detecting whether or not proper mixing or combining of the two component droplets have occurred.Type: GrantFiled: February 26, 2016Date of Patent: December 24, 2019Assignee: STOKES BIO LIMITEDInventors: Mauro Aguanno, Brian T. Chawke, Kieran Curran, Tara Dalton, Mark Davies, Xiaona Hou, David Kinahan, Mark Korenke, David McGuire, Michael Sayers, Noel Sirr, Ryan J. Talbot, Brian Barrett, Damian Curtin, Damien King, Conor McCarthy
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Patent number: 10384187Abstract: Complete nucleic acid library preparation devices are provided. Aspects of the devices include: a thermal chip module comprising multiple nodes; one or more plate locations; a robotically controlled liquid handler configured to transfer liquid between the one or more plate locations and the thermal chip module; and a bulk reagent dispenser configured to access each node of the thermal chip module.Type: GrantFiled: February 9, 2015Date of Patent: August 20, 2019Assignee: GENCELL BIOSYSTEMS LTDInventors: Kieran Curran, Brian Chawke, Noel Sirr
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Patent number: 10252261Abstract: Devices, systems and methods for making and handling liquid samples are disclosed.Type: GrantFiled: June 28, 2017Date of Patent: April 9, 2019Assignee: GENCELL BIOSYSTEMS LTD.Inventors: Kieran Curran, David McGuire, Brian Chawke, Paul Fleming, Brian Barrett, Noel Sirr
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Patent number: 10207271Abstract: Complete nucleic acid library preparation devices are provided. Aspects of the devices include: a thermal chip module comprising multiple CLC reaction wells; one or more plate locations; a robotically controlled liquid handler configured to transfer liquid between the one or more plate locations and the thermal chip module; and a bulk reagent dispenser configured to access each CLC reaction well of the thermal chip module.Type: GrantFiled: August 3, 2015Date of Patent: February 19, 2019Assignee: GENCELL BIOSYSTEMS LTD.Inventors: Brian Barrett, Noel Sirr, Brian Chawke, Kieran Curran, John Daly
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Patent number: 10125389Abstract: A sample handling method may include drawing an encapsulating liquid from an encapsulating-liquid input; discharging the drawn encapsulating liquid (a) onto a free surface of a carrier liquid in a carrier-liquid conduit comprising a stabilisation feature and (b) proximate to the stabilisation feature, the encapsulating liquid being immiscible with the carrier liquid, so that the discharged encapsulating liquid does not mix with the carrier liquid, floats on top of the carrier liquid, and is immobilised by the stabilisation feature; drawing a sample liquid from a sample-liquid input; and discharging the drawn sample liquid, the sample liquid being immiscible with the encapsulating liquid and with the carrier liquid, so that the sample liquid does not mix with the encapsulating liquid or with the carrier liquid.Type: GrantFiled: October 5, 2016Date of Patent: November 13, 2018Assignee: GENCELL BIOSYSTEMS LIMITEDInventors: Kieran Curran, Paul Fleming, Seamus Gilhooley, Micheál Keane, Inga Rosca, Patrick Tuohy
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Patent number: 10081808Abstract: Methods, devices and systems for handling sample liquids, encapsulating liquids and magnetic particles are disclosed.Type: GrantFiled: August 2, 2017Date of Patent: September 25, 2018Assignee: GENCELL BIOSYSTEMS LTDInventors: Kieran Curran, David McGuire
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Publication number: 20180111118Abstract: Devices, systems and methods for making and handling liquid samples are disclosed.Type: ApplicationFiled: June 28, 2017Publication date: April 26, 2018Inventors: Kieran Curran, David McGuire, Brian Chawke, Paul Fleming, Brian Barrett, Noel Sirr
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Patent number: 9951375Abstract: Methods, devices and systems for handling sample liquids, encapsulating liquids and magnetic particles are disclosed.Type: GrantFiled: June 18, 2014Date of Patent: April 24, 2018Assignee: Becton, Dickinson and CompanyInventors: Kieran Curran, Robert Roeven
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Publication number: 20180016573Abstract: Methods, devices and systems for handling sample liquids, encapsulating liquids and magnetic particles are disclosed.Type: ApplicationFiled: August 2, 2017Publication date: January 18, 2018Inventors: Kieran Curran, David McGuire
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Patent number: 9789484Abstract: Devices, systems, and methods for charging fluids are disclosed. The charging of fluids improves the mixing of fluids in microfluidic systems. The charging is performed by producing an ion field between an ionizing electrode and an opposed ground electrode. A fluid-containing vessel is positioned between the opposed electrodes and the ion field charges the fluid in the vessel.Type: GrantFiled: February 19, 2016Date of Patent: October 17, 2017Assignee: Stokes Bio LimitedInventors: Brian Chawke, Kieran Curran, David McGuire, Michael Sayers, Noel Sirr
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Patent number: 9776182Abstract: Devices, systems and methods for making and handling liquid samples are disclosed.Type: GrantFiled: November 26, 2013Date of Patent: October 3, 2017Assignee: GenCell Biosystems Ltd.Inventors: Kieran Curran, David McGuire, Brian Chawke, Paul Fleming, Brian Barrett, Noel Sirr
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Patent number: D998817Type: GrantFiled: February 26, 2021Date of Patent: September 12, 2023Assignee: AnuCell Biosystems LimitedInventors: John Daly, Kieran Curran, Macdara Glynn, Mark McCabe, David Merrigan, Jason Ryan, John P. Griffin, Caitriona Ryan, Martin Reddin