Abstract: A method of preparing an extract can include loading extraction material into an extraction cell or a capsule extraction cell having a first portion and a second portion with ground coffee having a particle size between 200 ?m to 400 ?m. The method can further include introducing a flow of extraction medium through the first portion of the extraction cell. The method can include, within less than 75 seconds, 3 minutes, or 30 minutes of introducing a portion of the flow of extraction medium into the extraction cell, withdrawing from a filter at the second portion of the extraction cell, extract that has been extracted from the extraction material by the portion of the flow of extraction medium introduced into the extraction cell.

Abstract: Various beverage preparation methods are disclosed. The beverage preparation method can include purifying a first portion of an extract with reverse osmosis. The method can further include concentrating a second portion of an extract with freeze concentration, the first portion of the extract being separate from the second portion of the extract. The method can further include spray drying the first portion of the extract and the second portion of the extract to produce dried particles. The ratio of the first portion of the extract and the second portion of the extract can be at least 3:1.

Abstract: Provided is a fixative composition comprising from at least 5 percent to 50 percent syrup, optionally honey, preferably, at least 10 syrup, and dextran and optionally coconut oil, optionally from at least 10 g/L to about 60 g/L of dextran, preferably about 50 g/L and/or from at least 0.5 percent to 15 percent coconut oil, preferably at least 1 percent coconut oil, methods of making the solution, methods of using the solution, for example methods for preserving a biological sample in said solution, and containers and kits comprising the solution.

Abstract: A method of preparing a white coffee extract can include loading extraction material into an extraction cell having a first portion and a second portion. The extraction material can include ground coffee with a density between 0.2 g/ml-0.4 g/ml and a mean particle diameter between 700 ?m to 900 ?m. The method can further include introducing a flow of extraction medium through the first portion of the extraction cell. The method can include, within less than 60 seconds of introducing a portion of the flow of extraction medium into the extraction cell, withdrawing from a filter at the second portion of the extraction cell, the white coffee extract that has been extracted from the extraction material by the portion of the flow of extraction medium introduced into the extraction cell. The extraction material can include ground white coffee.

Abstract: An upward flow extraction method, apparatus, and extract are disclosed. The upward flow extraction method can comprise loading extraction material into an extraction cell having a bottom portion and a top portion; introducing a first aliquot of extraction medium through the bottom portion of the extraction cell; expelling gas from the extraction cell through the top portion of the extraction cell; closing the top portion of the extraction cell and increasing the pressure in the extraction cell as extraction medium flows into the bottom portion of the extraction cell; stopping the flow of extraction medium into the extraction cell; steeping the extraction material in the extraction medium under pressure to produce an extract; and introducing a second aliquot of extraction medium through the bottom portion of the extraction cell to push extract through top portion of the extraction cell.

Abstract: A combination that includes: a flavonoid, for example in an amount from about 0.1 g to about 1.5 g; and one or more of: ascorbic acid, ascorbate, or a combination thereof, for example in an amount from about 0.2 g to about 2.0 g; N-acetyl cysteine, for example in an amount from about 0.10 g to about 1.2 g; alpha-lipoic acid, for example in an amount from about 0.05 g to about 0.60 g; and at least one carotenoid, for example in an amount from about 1 mg to about 50 mg. The combination may be used to mitigate or prevent nuclear DNA damage, mitochondrial DNA damage, lipid peroxidation, protein carbonylation, or any combination thereof in a subject caused by oxidative stress.

Abstract: A method of preparing an extract can include loading extraction material into an extraction cell having a first portion and a second portion with ground coffee at a density of between 0.2 g/ml-0.4 g/ml and the ground coffee having a particle size between 200 ?m to 400 ?m. The method can further include introducing a flow of extraction medium through the first portion of the extraction cell. The method can include, within less than 75 seconds of introducing a portion of the flow of extraction medium into the extraction cell, withdrawing from a filter at the second portion of the extraction cell, extract that has been extracted from the extraction material by the portion of the flow of extraction medium introduced into the extraction cell.

Abstract: An upward flow extraction method, apparatus, and extract are disclosed. The upward flow extraction method can comprise loading extraction material into an extraction cell having a bottom portion and a top portion; introducing a first aliquot of extraction medium through the bottom portion of the extraction cell; expelling gas from the extraction cell through the top portion of the extraction cell; closing the top portion of the extraction cell and increasing the pressure in the extraction cell as extraction medium flows into the bottom portion of the extraction cell; stopping the flow of extraction medium into the extraction cell; steeping the extraction material in the extraction medium under pressure to produce an extract; and introducing a second aliquot of extraction medium through the bottom portion of the extraction cell to push extract through top portion of the extraction cell.

Abstract: An upward flow extraction method, apparatus, and extract are disclosed. The upward flow extraction method can comprise loading extraction material into an extraction cell having a bottom portion and a top portion; introducing a first aliquot of extraction medium through the bottom portion of the extraction cell; expelling gas from the extraction cell through the top portion of the extraction cell; closing the top portion of the extraction cell and increasing the pressure in the extraction cell as extraction medium flows into the bottom portion of the extraction cell; stopping the flow of extraction medium into the extraction cell; steeping the extraction material in the extraction medium under pressure to produce an extract; and introducing a second aliquot of extraction medium through the bottom portion of the extraction cell to push extract through top portion of the extraction cell.

Abstract: The present disclosure relates to medical devices comprising detachable balloons and catheter assemblies, wherein the detachable balloons are polymer balloons, metal balloons, polymer-coated metal balloons, and metalized polymer balloons. Various means of attachment and detachment of the balloons to the catheter assemblies are described. Kits and uses of systems having one or more medical devices, detachable balloons, and elongated or expandable bodies are also disclosed.

Abstract: An upward flow extraction method, apparatus, and extract are disclosed. The upward flow extraction method can comprise loading extraction material into an extraction cell having a bottom portion and a top portion; introducing a first aliquot of extraction medium through the bottom portion of the extraction cell; expelling gas from the extraction cell through the top portion of the extraction cell; closing the top portion of the extraction cell and increasing the pressure in the extraction cell as extraction medium flows into the bottom portion of the extraction cell; stopping the flow of extraction medium into the extraction cell; steeping the extraction material in the extraction medium under pressure to produce an extract; and introducing a second aliquot of extraction medium through the bottom portion of the extraction cell to push extract through top portion of the extraction cell.

Abstract: A handle device is provided comprising a first wing and a second wing. The first wing and the second wing are configured to pivot about a common axis to one another. The first wing has one or more first ridge, and a first one or more clearance spaces. The second wing has one or more second ridges and a second one or more clearance spaces. The one or more first ridges is configured to be received within the second one or more clearance spaces and the one or more second ridges is configured to be received within the first one or more clearance spaces when the first wing is pivoted about the common axis to the second wing in a folded configuration.

Abstract: A handle device is provided comprising a first wing and a second wing. The first wing and the second wing are configured to pivot about a common axis to one another. The first wing has one or more first ridge, and a first one or more clearance spaces. The second wing has one or more second ridges and a second one or more clearance spaces. The one or more first ridges is configured to be received within the second one or more clearance spaces and the one or more second ridges is configured to be received within the first one or more clearance spaces when the first wing is pivoted about the common axis to the second wing in a folded configuration.

Abstract: Various embodiments are described herein for a system and a method for treatment planning for providing ablative therapy to a patient. The treatment planning may involve segmenting images of the patient to define areas to receive treatment, defining trial parameters, simulating treatment of ablative therapy to the patient according to the trial parameters; analyzing a thermal dose distribution resulting from the simulated treatment to determine treatment effectiveness; determining when the treatment effectiveness meets a treatment effectiveness criteria; and providing an indication of the trial parameters when the treatment effectiveness meets the treatment effectiveness criteria.

Abstract: An upward flow extraction method, apparatus, and extract are disclosed. The upward flow extraction method can comprise loading extraction material into an extraction cell having a bottom portion and a top portion; introducing a first aliquot of extraction medium through the bottom portion of the extraction cell; expelling gas from the extraction cell through the top portion of the extraction cell; closing the top portion of the extraction cell and increasing the pressure in the extraction cell as extraction medium flows into the bottom portion of the extraction cell; stopping the flow of extraction medium into the extraction cell; steeping the extraction material in the extraction medium under pressure to produce an extract; and introducing a second aliquot of extraction medium through the bottom portion of the extraction cell to push extract through top portion of the extraction cell.

Abstract: Vascular conditions are detected non-invasively in the human body using a collection of information from small local regions of the vasculature. An array of accelerometers are attached to the head and blood flow sounds are recorded. Vibration signatures of vessel structures such as branches, aneurysms, stenosis, etc. using random, periodic, band limited or transient analysis provides a signature library for further processing. The signature library is used to localize the origin of recognized vascular features and the localized feature is presented to the physician in a clinically relevant manner.

Abstract: The present specification provides, amongst other things, a method of treating scoliosis comprising delivering a therapeutically acceptable amount of a growth modulator to an epiphyseal growth plate to correct or compensate for disproportionate growth.

Abstract: Vascular conditions are detected non-invasively in the human body using a collection of information from small local regions of the vasculature. An array of accelerometers are attached to the head and blood flow sounds are recorded. Vibration signatures of vessel structures such as branches, aneurysms, stenosis, etc. using random, periodic, band limited or transient analysis provides a signature library for further processing. The signature library is used to localize the origin of recognized vascular features and the localized feature is presented to the physician in a clinically relevant manner.

Abstract: Various embodiments are described herein for a system and a method for treatment planning for providing ablative therapy to a patient. The treatment planning may involve segmenting images of the patient to define areas to receive treatment, defining trial parameters, simulating treatment of ablative therapy to the patient according to the trial parameters; analyzing a thermal dose distribution resulting from the simulated treatment to determine treatment effectiveness; determining when the treatment effectiveness meets a treatment effectiveness criteria; and providing an indication of the trial parameters when the treatment effectiveness meets the treatment effectiveness criteria.

Abstract: An apparatus for administering a therapeutic is provided. In various embodiments, the apparatus includes an ozone generator for producing therapeutic oxygen-ozone mixture. The generator includes an electrochemical cell configured to communicate with an accumulator having an anode, a cathode and a power supply in electrical communication with the anode and the cathode. The power supply is configured to create an electric current between the anode and the cathode such that water in the electrochemical cell electrolyzes to produce ozone and oxygen at the anode.