Patents by Inventor Kieron Brown

Kieron Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTAL STRUCTURE OF TAK1-TAB1
    Publication number: 20110171714
    Abstract: The invention relates to molecules or molecular complexes which comprise binding pockets of TAK1 or its structural homologues. The invention relates to crystallizable compositions and crystals comprising TAK1. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the TAK1 or TAK1-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to TAK1 or homologues thereof.
    Type: Application
    Filed: January 7, 2011
    Publication date: July 14, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Graham Cheetham, Kieron Brown, Sarah Vial, Neesha Dedi
  • Crystal structure of polo-like kinase 3 (PLK3) and binding pockets thereof
    Patent number: 7700340
    Abstract: The invention relates to molecules or molecular complexes, which comprise binding pockets of PLK3 or its structural homologues. The invention relates to crystallizable compositions and crystals comprising PLK3. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the PLK3 or PLK3-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for, identify and design compounds, including inhibitory compounds that bind to PLK3 or homologues thereof.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: April 20, 2010
    Assignee: Vertex Pharmaceuticals incorporated
    Inventors: Kieron Brown, Graham M T Cheetham, Suzanne B Renwick, Joanna M Long
  • Crystal structure of polo-like kinase 3 (PLK3) and binding pockets thereof
    Publication number: 20080293579
    Abstract: The invention relates to molecules or molecular complexes, which comprise binding pockets of PLK3 or its structural homologues. The invention relates to crystallizable compositions and crystals comprising PLK3. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the PLK3 or PLK3-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for, identify and design compounds, including inhibitory compounds that bind to PLK3 or homologues thereof.
    Type: Application
    Filed: June 14, 2007
    Publication date: November 27, 2008
    Inventors: Kieron Brown, Graham MT Cheetham, Suzanne B. Renwick, Joanna M. Long
  • Crystal structure of TAK1-TAB1
    Publication number: 20070178573
    Abstract: The invention relates to molecules or molecular complexes which comprise binding pockets of TAK1 or its structural homologues. The invention relates to crystallizable compositions and crystals comprising TAK1. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the TAK1 or TAK1-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to TAK1 or homologues thereof.
    Type: Application
    Filed: February 23, 2006
    Publication date: August 2, 2007
    Inventors: Graham Cheetham, Kieron Brown, Sarah Vial, Neesha Dedi
  • Crystal structure of interleukin-2 tyrosine kinase (ITK) and binding pockets thereof
    Publication number: 20060030016
    Abstract: The invention relates to molecules or molecular complexes which comprise binding pockets of ITK or its structural homologues. The invention relates to crystallizable compositions and crystals comprising ITK. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the ITK or ITK-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to ITK or homologues thereof.
    Type: Application
    Filed: December 3, 2004
    Publication date: February 9, 2006
    Inventors: Graham Cheetham, Kieron Brown, Ronald Knegtel, Suzanne Renwick, Sarah Vial