Patents by Inventor Kieu Mong LAM

Kieu Mong LAM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIPID NANOPARTICLES FOR DELIVERING THERAPEUTICS TO LUNGS
    Publication number: 20240065982
    Abstract: Certain embodiments of the invention provide lipid nanoparticles for delivery nucleic acid therapeutics to the lungs.
    Type: Application
    Filed: July 8, 2021
    Publication date: February 29, 2024
    Applicant: GENEVANT SCIENCES GMBH
    Inventors: James Heyes, Kieu Mong Lam, Lorne Ralph Palmer
  • CATIONIC LIPIDS FOR LIPID NANOPARTICLE DELIVERY OF THERAPEUTICS TO HEPATIC STELLATE CELLS
    Publication number: 20230150926
    Abstract: Certain embodiments of the invention provide lipids useful for preparing lipid nanoparticles for delivering therapeutic agents to, e.g., hepatic stellate cells.
    Type: Application
    Filed: March 12, 2021
    Publication date: May 18, 2023
    Applicant: GENEVANT SCIENCES GMBH
    Inventors: James HEYES, Kieu Mong Lam, Richard J. Holland
  • CATIONIC LIPIDS FOR LIPID NANOPARTICLE DELIVERY OF THERAPEUTICS TO HEPATIC STELLATE CELLS
    Publication number: 20230139594
    Abstract: Certain embodiments of the invention provide lipids useful for preparing lipid nanoparticles for delivering therapeutic agents to, e.g., hepatic stellate cells.
    Type: Application
    Filed: February 11, 2021
    Publication date: May 4, 2023
    Applicant: GENEVANT SCIENCES GMBH
    Inventors: James HEYES, Kieu Mong LAM, Richard J. HOLLAND, Wenxuan ZHANG
  • LIPID NANOPARTICLES
    Publication number: 20220168222
    Abstract: The invention provides lipid nanoparticles and formulations containing lipid nanoparticles.
    Type: Application
    Filed: April 24, 2020
    Publication date: June 2, 2022
    Applicant: GENEVANT SCIENCES GMBH
    Inventors: James HEYES, Adam JUDGE, Kieu Mong LAM, Alan D. MARTIN
  • COMPOSITIONS AND METHODS FOR DELIVERING MESSENGER RNA
    Publication number: 20220160899
    Abstract: The present invention provides compositions comprising nucleic acid molecules, such as mRNA molecules, encapsulated within lipid particles. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease.
    Type: Application
    Filed: November 1, 2021
    Publication date: May 26, 2022
    Applicant: ARBUTUS BIOPHARMA CORPORATION
    Inventors: Michael J. ABRAMS, James HEYES, Adam JUDGE, Kieu Mong LAM, Lorne Ralph PALMER, Stephen P. REID, Edward D. YAWORSKI
  • CATIONIC LIPIDS CONTAINING SILICON
    Publication number: 20220133636
    Abstract: Certain embodiments of the invention provide a cationic lipid of formula (I): wherein R1, R2, R3 and R4 are defined as described herein, as well as methods of making these lipids. Certain embodiments of the invention also provide nucleic acid-lipid particles comprising a cationic lipid of formula (I), methods of making the lipid particles, and methods of delivering and/or administering the lipid particles.
    Type: Application
    Filed: November 8, 2019
    Publication date: May 5, 2022
    Inventors: Michael J. ABRAMS, James HEYES, Richard J. HOLLAND, Kieu Mong LAM, Mark WOOD
  • NEGATIVELY CHARGED PEG-LIPID CONJUGATES
    Publication number: 20220072154
    Abstract: The invention provides PEG-conjugated lipids of formula (I): A-B-C (I) wherein A, B, and C have any of the values defined in the specification, as well as compositions comprising the PEG-conjugated lipids of formula (I), nucleic acid lipid nanoparticles comprising the PEG-conjugated lipids of formula (I), and methods of using the PEG-conjugated lipids of formula (I), the compositions, and the nucleic acid nanoparticles.
    Type: Application
    Filed: November 8, 2019
    Publication date: March 10, 2022
    Applicant: ARBUTUS BIOPHARMA CORPORATION
    Inventors: James HEYES, Kieu Mong LAM, Mark WOOD
  • THERAPEUTIC METHODS
    Publication number: 20220031847
    Abstract: The invention provides methods and compositions for delivering a nucleic acid to a cell or the cytosol of the target cell. The method includes contacting the cell with, 1) a membrane-destabilizing polymer; and 2) a nucleic acid conjugate. The nucleic acid conjugate includes a targeting ligand bound to an optional linker and a nucleic acid.
    Type: Application
    Filed: November 4, 2019
    Publication date: February 3, 2022
    Applicant: GENEVANT SCIENCES GMBH
    Inventors: James HEYES, Richard J. HOLLAND, Adam JUDGE, Kieu Mong LAM
  • LIPID NANOPARTICLE FORMULATIONS
    Publication number: 20220001029
    Abstract: The invention provides certain specific lipid nanoparticles comprising: (a) one or more nucleic acid molecules; (b) cholesterol; (c) DSPC; (d) PEG-C-DMA; and (b) a cationic lipid of formula CL1 or CL2, and pharmaceutical compositions comprising the lipid nanoparticles. The lipid nanoparticles and pharmaceutical compositions are particularly useful for delivering a nucleic acid to a patient (e.g. a human) or to a cell.
    Type: Application
    Filed: November 8, 2019
    Publication date: January 6, 2022
    Applicant: ARBUTUS BIOPHARMA CORPORATION
    Inventors: Kieu Mong LAM, Alan D. MARTIN, Petra SCHREINER
  • LIPID NANOPARTICLE FORMULATIONS
    Publication number: 20220000778
    Abstract: The invention provides certain specific lipid nanoparticles comprising: (a) one or more nucleic acid molecules; (b) cholesterol; (c) DSPC; (d) PEG-C-DMA; and (e) a cationic lipid; and pharmaceutical compositions comprising the lipid nanoparticles. The lipid nanoparticles and pharmaceutical compositions are particularly useful for delivering a nucleic acid such as siRNA or mRNA to a patient (e.g. a human) or to a cell.
    Type: Application
    Filed: November 8, 2019
    Publication date: January 6, 2022
    Applicant: ARBUTUS BIOPHARMA CORPORATION
    Inventors: James HEYES, Adam JUDGE, Kieu Mong LAM, Lorne Ralph PALMER, Petra SCHREINER
  • Compositions and methods for delivering messenger RNA
    Patent number: 11191849
    Abstract: The present invention provides compositions comprising nucleic acid molecules, such as mRNA molecules, encapsulated within lipid particles. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: December 7, 2021
    Assignee: ARBUTUS BIOPHARMA CORPORATION
    Inventors: Michael J. Abrams, James Heyes, Adam Judge, Kieu Mong Lam, Lorne Ralph Palmer, Stephen P. Reid, Edward D. Yaworski
  • COMPOSITIONS AND METHODS FOR DELIVERING MESSENGER RNA
    Publication number: 20190240354
    Abstract: The present invention provides compositions comprising nucleic acid molecules, such as mRNA molecules, encapsulated within lipid particles. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease.
    Type: Application
    Filed: June 30, 2017
    Publication date: August 8, 2019
    Applicant: ARBUTUS BIOPHARMA CORPORATION
    Inventors: Michael J. ABRAMS, James HEYES, Adam JUDGE, Kieu Mong LAM, Lorne Ralph PALMER, Stephen P. REID, Edward D. YAWORSKI