Patents by Inventor Kihito Hada
Kihito Hada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11964950Abstract: The present disclosure provides, for example, a compound represented by the general formula below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt: wherein X1, X2, X3 and X4 are each independently —CR2? or N?, R2 is, for example, a halogen atom, R1 is, for example, —S(?O)2—NH—R8, R8 is, for example, a C1-6 alkyl group, R3 is, for example, a hydrogen atom, R5 is, for example, a halogen atom, R6 is, for example, a hydrogen atom, and R4 is, for example, a cyclopropyl group. The compounds, salts or solvates provided by the present disclosure exhibit high RAF/MEK complex-stabilizing activity and can be used for the treatment or prevention of cell proliferative disorders, particularly cancers.Type: GrantFiled: July 20, 2022Date of Patent: April 23, 2024Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Yoshiaki Isshiki, Fumio Watanabe, Masaki Tomizawa, Kihito Hada, Kazuo Hattori, Kenichi Kawasaki, Ikumi Hyodo, Toshihiro Aoki
-
Publication number: 20230002333Abstract: The present disclosure provides, for example, a compound represented by general formula (6) below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt: wherein X1, X2, X3 and X4 are each independently —CR2? or —N?, R2 is, for example, a halogen atom, R1 is, for example, —S(?O)2—NH—R8, R8 is, for example, a C1-6 alkyl group, R3 is, for example, a hydrogen atom, R5 is, for example, a halogen atom, R6 is, for example, a hydrogen atom, and R4 is, for example, a cyclopropyl group. The compounds, salts or solvates provided by the present disclosure exhibit high RAF/MEK complex-stabilizing activity and can be used for the treatment or prevention of cell proliferative disorders, particularly cancers.Type: ApplicationFiled: July 20, 2022Publication date: January 5, 2023Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Yoshiaki Isshiki, Fumio Watanabe, Masaki Tomizawa, Kihito Hada, Kazuo Hattori, Kenichi Kawasaki, Ikumi Hyodo, Toshihiro Aoki
-
Patent number: 10005739Abstract: The present invention relates to quinazolinone and isoquinolinone derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.Type: GrantFiled: October 23, 2014Date of Patent: June 26, 2018Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Takeshi Murata, Sousuke Hara, Satoshi Niizuma, Kihito Hada, Hatsuo Kawada, Masahiro Sakaitani, Hideaki Shimada, Yoshito Nakanishi
-
Patent number: 9695118Abstract: The present invention relates to benzamide derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.Type: GrantFiled: April 24, 2013Date of Patent: July 4, 2017Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Takeshi Murata, Satoshi Niizuma, Sousuke Hara, Hatsuo Kawada, Kihito Hada, Hideaki Shimada, Hiroshi Tanaka, Yoshito Nakanishi
-
Patent number: 9567304Abstract: The present invention relates to quinazolinedione derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.Type: GrantFiled: April 24, 2013Date of Patent: February 14, 2017Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Takeshi Murata, Hatsuo Kawada, Satoshi Niizuma, Sousuke Hara, Kihito Hada, Hideaki Shimada, Hiroshi Tanaka, Toshiyuki Mio
-
Publication number: 20160272595Abstract: The present invention relates to quinazolinone and isoquinolinone derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: October 23, 2014Publication date: September 22, 2016Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Takeshi MURATA, Sousuke HARA, Satoshi NIIZUMA, Kihito HADA, Hatsuo KAWADA, Masahiro SAKAITANI, Hideaki SHIMADA, Yoshito NAKANISHI
-
Publication number: 20150152047Abstract: The present invention relates to benzamide derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: April 24, 2013Publication date: June 4, 2015Inventors: Takeshi Murata, Satoshi Niizuma, Sousuke Hara, Hatsuo Kawada, Kihito Hada, Hideaki Shimada, Hiroshi Tanaka, Yoshito Nakanishi
-
Publication number: 20150141400Abstract: The present invention relates to quinazolinedione derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: April 24, 2013Publication date: May 21, 2015Inventors: Takeshi Murata, Hatsuo Kawada, Satoshi Niizuma, Sousuke Hara, Kihito Hada, Hideaki Shimada, Hiroshi Tanaka, Toshiyuki Mio
-
Patent number: 8362236Abstract: The present invention provides a novel class of compounds that have the activity of inhibiting HSP90 enzyme and are useful as anti-cancer agents or such, and compounds that are useful as synthetic intermediates thereof. Specifically, the present invention provides compounds represented by the following formula (1), and pharmaceutically acceptable salts thereof: wherein X, R1, R2, R3, R4, R5, R6, R7, L1, L2, and L3 are as defined in the specification.Type: GrantFiled: February 29, 2008Date of Patent: January 29, 2013Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Nobuo Shimma, Takuo Tsukuda, Hiroshi Koyano, Atsushi Suda, Tadakatsu Hayase, Kihito Hada, Ken-Ichi Kawasaki, Susumu Komiyama, Naomi Ono, Toshikazu Yamazaki, Ryoichi Saitoh, Masami Kohchi, Kiyoshi Hasegawa
-
Patent number: 8063046Abstract: Compounds having high angiogenesis inhibiting activity useful as agents for effective treatment and prevention of diseases involving pathologic angiogenesis, e.g.Type: GrantFiled: March 23, 2010Date of Patent: November 22, 2011Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroshi Koyano, Atsushi Suda, Kousuke Aso, Kihito Hada, Miyuki Asai, Masami Hasegawa, Yasuko Sato
-
Publication number: 20100179326Abstract: Compounds having high angiogenesis inhibiting activity useful as agents for effective treatment and prevention of diseases involving pathologic angiogenesis, e.g.Type: ApplicationFiled: March 23, 2010Publication date: July 15, 2010Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Hiroshi KOYANO, Atsushi Suda, Kousuke Aso, Kihito Hada, Miyuki Asai, Masami Hasegawa, Yasuko Sato
-
Patent number: 7705053Abstract: To provide compounds which have high angiogenesis inhibiting activity, and are useful as agents for effective treatment and prevention of diseases involving pathologic angiogenesis, for example, cancer and cancer metastasis, methods for producing the compounds, intermediate compounds useful for their production, and pharmaceutical compositions containing these compounds.Type: GrantFiled: December 27, 2004Date of Patent: April 27, 2010Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroshi Koyano, Atsushi Suda, Kousuke Aso, Kihito Hada, Miyuki Asai, Masami Hasegawa, Yasuko Sato
-
Publication number: 20100056510Abstract: The present invention provides a novel class of compounds that have the activity of inhibiting HSP90 enzyme and are useful as anti-cancer agents or such, and compounds that are useful as synthetic intermediates thereof. Specifically, the present invention provides compounds represented by the following formula (1), and pharmaceutically acceptable salts thereof: wherein X, R1, R2, R3, R4, R5, R6, R7, L1, L2, and L3 are as defined in the specification.Type: ApplicationFiled: February 29, 2008Publication date: March 4, 2010Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Nobuo Shimma, Takuo Tsukuda, Hiroshi Koyano, Atsushi Suda, Tadakatsu Hayase, Kihito Hada, Ken-ichi Kawasaki, Susumu Komiyama, Naomi Ono, Toshikazu Yamazaki, Ryoichi Saitoh, Masami Kohchi, Kiyoshi Hasegawa
-
Publication number: 20070123493Abstract: To provide compounds which have high angiogenesis inhibiting activity, and are useful as agents for effective treatment and prevention of diseases involving pathologic angiogenesis, for example, cancer and cancer metastasis, methods for producing the compounds, intermediate compounds useful for their production, and pharmaceutical compositions containing these compounds.Type: ApplicationFiled: December 27, 2004Publication date: May 31, 2007Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Hiroshi Koyano, Atsushi Suda, Kousuke Aso, Kihito Hada, Miyuki Asai, Masami Hasegawa, Yasuko Sato