Abstract: An object of the present invention is to reduce formation of visually detectable particles in a formulation for injection in which a solution containing a protein is filled in a container. The present invention provides a method for determining a protein having a high risk of forming particles.

Abstract: The present invention relates to anti-HLA-DQ2.5 antibodies and formulations containing the same. The present invention provides anti-HLA-DQ2.5 antibodies that have been modified. The anti-HLA-DQ2.5 antibodies of the invention have binding activity to complexes formed by HLA-DQ2.5 and a gluten peptide, but have substantially no binding activity to complexes formed by HLA-DQ2.5 and an irrelevant peptide. Furthermore, the antibodies of the invention are shown to have inhibitory effects on T cell activation by gluten peptides. The present invention also relates to formulations, in particular, formulations for injection, containing an anti-HLA-DQ2.5 antibody.

Abstract: Provided is a syringe including: a barrel; and a partitioning device, the partitioning device including: a cylindrical housing; and an inner plug, the housing including an engaging part configured to engage with the inner plug in an out-of-communication state, the inner plug including an engaged part configured to engage with the engaging part from a proximal side in the out-of-communication state, and the partitioning device being configured so that, when a pressing force is applied from the proximal side, one of the engaging part and the engaged part rides over an other one thereof and release engagement between the engaging part and the engaged part, thereby allowing the inner plug to have the proximal side space inside the housing and the distal side space inside the housing communicating with each other to achieve communication between the proximal side space inside the barrel and the distal side space inside the barrel.

Abstract: A syringe is provided with a barrel having a distal end part provided with an outlet opening; a filter disposed closer to a proximal side than the outlet opening inside the barrel; and a holding member. A proximal side part disposed closer to the proximal side than the filter of the holding member has a flow path, a proximal side space into which the medicine flows through the flow path is provided on the proximal side of the filter, a distal side space into which the medicine flows from the proximal side space via the filter is provided on the distal side of the filter, and an area of the outlet opening is smaller than an area of the proximal side space, smaller than an area of the distal side space, and smaller than an area of the flow path.