Patents by Inventor Kiichiro Nabeta
Kiichiro Nabeta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11213486Abstract: The drug-containing fat emulsion of the present invention, which comprises at least a slightly water soluble drug, an oil or fat, an emulsifier, and water as components, is characterized by having a content of the oil or fat of 2 to 120 mg/mL (excluding 2 mg/mL), having a weight ratio of the drug to the oil or fat (drug/(oil or fat)) of 0.001 to 20 (provided that the total content of the drug and the oil or fat is at most 125 mg/mL), having a content of lecithin as the emulsifier of 50 to 200 mg/mL (in which 50% by weight or less of the used lecithin is optionally replaced by an emulsifier other than lecithin), and having a turbidity of 0.5 or lower.Type: GrantFiled: January 10, 2018Date of Patent: January 4, 2022Assignee: TECHNO GUARD CO. LTD.Inventor: Kiichiro Nabeta
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Publication number: 20210069110Abstract: An object of the present invention is to provide a non-aqueous composition having a drug carried therein, the composition being capable of preparing a drug-containing fat emulsion that is usable as an injection, an eye drop, a nasal drop, an inhalant, or the like by being mixed with an aqueous medium in use without producing a drug-containing fat emulsion in advance, and a method for producing the non-aqueous composition. The non-aqueous composition having a drug carried therein of the present invention as a resolution for achieving the object is characterized by comprising an oil or fat, a slightly water soluble drug, and an emulsifier which are dissolved in a polyhydric alcohol as a water soluble carrier at a content of the oil or fat of 0.05 to 250 mg/g, a weight ratio of the slightly water soluble drug to the oil or fat (slightly water soluble drug/(oil or fat)) of 0.Type: ApplicationFiled: March 31, 2018Publication date: March 11, 2021Applicant: Techno Guard Co. Ltd.Inventor: Kiichiro NABETA
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Patent number: 10842770Abstract: Non-aqueous taxane pro-emulsion formulations are provided. Pro-emulsion formulations of embodiments of the invention include a taxane, an oil component, a surfactant component and, optionally, a non-aqueous solvent component. Also provided are methods of making and using the pro-emulsion formulations, as well as kits that include the pro-emulsion formulations.Type: GrantFiled: April 29, 2011Date of Patent: November 24, 2020Assignee: Teikoku Pharma USA, Inc.Inventor: Kiichiro Nabeta
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Publication number: 20190160008Abstract: The drug-containing fat emulsion of the present invention, which comprises at least a slightly water soluble drug, an oil or fat, an emulsifier, and water as components, is characterized by having a content of the oil or fat of 2 to 120 mg/mL (excluding 2 mg/mL), having a weight ratio of the drug to the oil or fat (drug/(oil or fat)) of 0.001 to 20 (provided that the total content of the drug and the oil or fat is at most 125 mg/mL), having a content of lecithin as the emulsifier of 50 to 200 mg/mL (in which 50% by weight or less of the used lecithin is optionally replaced by an emulsifier other than lecithin), and having a turbidity of 0.5 or lower.Type: ApplicationFiled: January 10, 2018Publication date: May 30, 2019Applicant: Techno Guard Co. Ltd.Inventor: Kiichiro NABETA
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Publication number: 20180177820Abstract: An object of the present invention is to provide a protective composition for gastrointestinal mucosa, for example, for inhibiting occurrence of a gastrointestinal mucosa disorder when an oral drug that induces the gastrointestinal mucosa disorder is taken. The protective composition for gastrointestinal mucosa of the present invention as a resolution for achieving the object is characterized by comprising at least a macromolecular polysaccharide, sodium hydrogen carbonate and/or magnesium carbonate, and a polyhydric alcohol. According to the protective composition for gastrointestinal mucosa of the present invention, sodium hydrogen carbonate or magnesium carbonate foams through contact with a gastric juice in stomach to thereby generate diffusing power for the macromolecular polysaccharide. This power can allow the macromolecular polysaccharide to quickly dissolve or disperse in the gastric juice and allow the macromolecular polysaccharide to effectively exert a gastric mucosa protective action.Type: ApplicationFiled: October 13, 2016Publication date: June 28, 2018Applicant: TECHNO GUARD CO. LTD.Inventor: Kiichiro NABETA
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Patent number: 9763880Abstract: Non-aqueous, ethanol-free taxane formulations are provided. Formulations of embodiments of the invention include a taxane, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid component, wherein the organic acid component is soluble in the non-aqueous solvent and the amount by weight of non-ionic surfactant is equal to or greater than the amount by weight of non-aqueous solvent. Also provided are methods of using the formulations, as well as kits that include the formulations. Non-aqueous, ethanol-free docetaxel formulations are provided. Formulations of embodiments of the invention include docetaxel, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid which is soluble in the non-aqueous solvent and is substantially free of any conjugate base. Also provided are methods of using the formulations, as well as kits that include the formulations.Type: GrantFiled: March 10, 2016Date of Patent: September 19, 2017Assignee: Teikoku Pharma USA, Inc.Inventor: Kiichiro Nabeta
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Publication number: 20160287627Abstract: [Problem] To suppress the onset of adverse effects of drugs that cause gastric ulcers as an adverse effect. [Solution] The onset of gastric ulcers induced by a drug is suppressed by incorporating, into a pharmaceutical composition containing a drug having gastric ulcers as an adverse effect, a high-molecular polysaccharide that has a molecular weight of 800,000-3,000,000 and that produces a gel when a 0.3% aqueous solution thereof is added dropwise to artificial gastric juice.Type: ApplicationFiled: November 19, 2014Publication date: October 6, 2016Applicants: KEWPIE CORPORATION, TECHNO GUARD CO., LTD.Inventors: Shuta FURUKI, Hideto YOSHIDA, Kiichiro NABETA
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Patent number: 9427435Abstract: Methods and compositions of treating a subject for cancer pain are provided. In the subject methods, a subject is treated for cancer pain by administering to the subject an effective amount of a narcotic emulsion, e.g., fentanyl elmulsion, formulation. In certain embodiments, the emulsion formulations include a narcotic active agent, oil, water and a surfactant. Also provided are methods of making the subject emulsion formulations as well as kits that include the emulsion formulations.Type: GrantFiled: September 22, 2014Date of Patent: August 30, 2016Assignees: Teikoku Pharma USA, Inc., Techno Guard Co., Ltd.Inventors: Kiichiro Nabeta, Toru Hibi
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Publication number: 20160206560Abstract: Non-aqueous, ethanol-free taxane formulations are provided. Formulations of embodiments of the invention include a taxane, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid component, wherein the organic acid component is soluble in the non-aqueous solvent and the amount by weight of non-ionic surfactant is equal to or greater than the amount by weight of non-aqueous solvent. Also provided are methods of using the formulations, as well as kits that include the formulations. Non-aqueous, ethanol-free docetaxel formulations are provided. Formulations of embodiments of the invention include docetaxel, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid which is soluble in the non-aqueous solvent and is substantially free of any conjugate base. Also provided are methods of using the formulations, as well as kits that include the formulations.Type: ApplicationFiled: March 10, 2016Publication date: July 21, 2016Applicant: Teikoku Pharma USA, Inc.Inventor: Kiichiro Nabeta
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Patent number: 9308195Abstract: Non-aqueous, ethanol-free taxane formulations are provided. Formulations of embodiments of the invention include a taxane, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid component, wherein the organic acid component is soluble in the non-aqueous solvent and the amount by weight of non-ionic surfactant is equal to or greater than the amount by weight of non-aqueous solvent. Also provided are methods of using the formulations, as well as kits that include the formulations. Non-aqueous, ethanol-free docetaxel formulations are provided. Formulations of embodiments of the invention include docetaxel, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid which is soluble in the non-aqueous solvent and is substantially free of any conjugate base. Also provided are methods of using the formulations, as well as kits that include the formulations.Type: GrantFiled: December 9, 2014Date of Patent: April 12, 2016Assignee: Teikoku Pharma USA, Inc.Inventor: Kiichiro Nabeta
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Publication number: 20150141461Abstract: Methods and compositions of treating a subject for cancer pain are provided. In the subject methods, a subject is treated for cancer pain by administering to the subject an effective amount of a narcotic emulsion, e.g., fentanyl elmulsion, formulation. In certain embodiments, the emulsion formulations include a narcotic active agent, oil, water and a surfactant. Also provided are methods of making the subject emulsion formulations as well as kits that include the emulsion formulations.Type: ApplicationFiled: September 22, 2014Publication date: May 21, 2015Inventors: Kiichiro Nabeta, Toru Hibi
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Patent number: 9006280Abstract: Pyrazolone derivative formulations are provided. The formulations include a pyrazolone derivative active agent, e.g., edaravone, and an amphiphilic solubilizing agent. Also provided are methods of making and using the subject formulations.Type: GrantFiled: November 18, 2009Date of Patent: April 14, 2015Assignees: Teikoku Pharma USA, Inc., Techno Guard Co., Ltd.Inventor: Kiichiro Nabeta
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Publication number: 20150094361Abstract: Non-aqueous, ethanol-free taxane formulations are provided. Formulations of embodiments of the invention include a taxane, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid component, wherein the organic acid component is soluble in the non-aqueous solvent and the amount by weight of non-ionic surfactant is equal to or greater than the amount by weight of non-aqueous solvent. Also provided are methods of using the formulations, as well as kits that include the formulations. Non-aqueous, ethanol-free docetaxel formulations are provided. Formulations of embodiments of the invention include docetaxel, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid which is soluble in the non-aqueous solvent and is substantially free of any conjugate base. Also provided are methods of using the formulations, as well as kits that include the formulations.Type: ApplicationFiled: December 9, 2014Publication date: April 2, 2015Applicant: Teikoku Pharma USA, Inc,Inventor: Kiichiro Nabeta
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Patent number: 8940786Abstract: Non-aqueous, ethanol-free taxane nanodispersion formulations are provided. Nanodispersion formulations of embodiments of the invention include a taxane, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid component, wherein the organic acid component is soluble in the non-aqueous solvent and the amount by weight of non-ionic surfactant is equal to or greater than the amount by weight of non-aqueous solvent. Also provided are methods of using the nanodispersion formulations, as well as kits that include the nanodispersion formulations. Non-aqueous, ethanol-free docetaxel nanodispersion formulations are provided. Nanodispersion formulations of embodiments of the invention include docetaxel, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid which is soluble in the non-aqueous solvent and is substantially free of any conjugate base. Also provided are methods of using the nanodispersion formulations, as well as kits that include the nanodispersion formulations.Type: GrantFiled: September 30, 2013Date of Patent: January 27, 2015Assignee: Teikoku Pharma USA, Inc.Inventor: Kiichiro Nabeta
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Patent number: 8871791Abstract: Methods and compositions of treating a subject for cancer pain are provided. In the subject methods, a subject is treated for cancer pain by administering to the subject an effective amount of a narcotic emulsion, e.g., fentanyl elmulsion, formulation. In certain embodiments, the emulsion formulations include a narcotic active agent, oil, water and a surfactant. Also provided are methods of making the subject emulsion formulations as well as kits that include the emulsion formulations.Type: GrantFiled: January 11, 2010Date of Patent: October 28, 2014Assignees: Teikoku Pharma USA, Inc., Techno Guard Co., Ltd.Inventors: Kiichiro Nabeta, Toru Hibi
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Publication number: 20140094509Abstract: Non-aqueous, ethanol-free taxane nanodispersion formulations are provided. Nanodispersion formulations of embodiments of the invention include a taxane, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid component, wherein the organic acid component is soluble in the non-aqueous solvent and the amount by weight of non-ionic surfactant is equal to or greater than the amount by weight of non-aqueous solvent. Also provided are methods of using the nanodispersion formulations, as well as kits that include the nanodispersion formulations. Non-aqueous, ethanol-free docetaxel nanodispersion formulations are provided. Nanodispersion formulations of embodiments of the invention include docetaxel, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid which is soluble in the non-aqueous solvent and is substantially free of any conjugate base. Also provided are methods of using the nanodispersion formulations, as well as kits that include the nanodispersion formulations.Type: ApplicationFiled: September 30, 2013Publication date: April 3, 2014Applicant: Teikoku Pharma USA, Inc.Inventor: Kiichiro Nabeta
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Publication number: 20140094510Abstract: Non-aqueous, ethanol-free taxane nanodispersion formulations are provided. Nanodispersion formulations of embodiments of the invention include a taxane, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid component, wherein the organic acid component is soluble in the non-aqueous solvent and the amount by weight of non-ionic surfactant is equal to or greater than the amount by weight of non-aqueous solvent. Also provided are non-aqueous, ethanol-free docetaxel nanodispersion formulations. Nanodispersion formulations of embodiments of the invention include docetaxel, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid which is soluble in the non-aqueous solvent and is substantially free of any conjugate base. Also provided are methods of using the nanodispersion formulations, as well as kits that include the nanodispersion formulations.Type: ApplicationFiled: September 30, 2013Publication date: April 3, 2014Applicant: Teikoku Pharma USA, Inc.Inventor: Kiichiro Nabeta
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Publication number: 20140088181Abstract: Taxane pro-emulsion formulations are provided. Pro-emulsion formulations are dried powders that include a taxane, oil, surfactant and sugar alcohol. Also provided are methods of making and using the pro-emulsion formulations, as well as kits that include the pro-emulsion formulations.Type: ApplicationFiled: September 12, 2013Publication date: March 27, 2014Applicant: Teikoku Pharma USA, Inc.Inventor: Kiichiro Nabeta
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Patent number: 8168670Abstract: Pyrazolone derivative emulsion formulations are provided. The emulsion formulations include a pyrazolone derivative active agent, e.g., Edaravone, oil, water and an emulsifier. Also provided are methods of making and using the subject emulsion formulations.Type: GrantFiled: November 7, 2008Date of Patent: May 1, 2012Assignees: Teikoku Pharma USA, Inc., Techno Guard Co., Ltd.Inventor: Kiichiro Nabeta
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Publication number: 20110269829Abstract: Non-aqueous taxane pro-emulsion formulations are provided. Pro-emulsion formulations of embodiments of the invention include a taxane, an oil component, a surfactant component and, optionally, a non-aqueous solvent component. Also provided are methods of making and using the pro-emulsion formulations, as well as kits that include the pro-emulsion formulations.Type: ApplicationFiled: April 29, 2011Publication date: November 3, 2011Inventor: Kiichiro Nabeta