Patents by Inventor Kikuo Igarashi

Kikuo Igarashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for production of diltiazem hydrochloride
    Patent number: 4552695
    Abstract: New route to diltiazem hydrochloride of the formula: ##STR1## in which the starting cinnamyl alcohols are epoxidized by a special asymmetric synthesis followed by a series of stereospecific reactions; no optical resolution is required at any stage.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: November 12, 1985
    Assignee: Shionogi & Co., Ltd.
    Inventors: Kikuo Igarashi, Tsunetoshi Honma
  • Apramycin derivatives
    Patent number: 4370475
    Abstract: Novel 5,6-dideoxyapramycin derivatives having reinforced antimicrobial activity against gram-positive and negative bacteria with less side effects than apramycin, and produced by sulfonylation of 5- and 6-hydroxy groups and the subsequent reductive removal of sulfonates.
    Type: Grant
    Filed: October 22, 1981
    Date of Patent: January 25, 1983
    Assignee: Shionogi & Co., Ltd.
    Inventors: Kikuo Igarashi, Tsunetoshi Honma, Tamio Sugawara
  • Aprosamine derivatives
    Patent number: 4362866
    Abstract: New aprosamine derivatives having the reinforced antimicrobial activity against gram-positive and negative bacteria with less side effects than apramycin, and produced by chemical modification of 8'-hydroxy group of aprosamine obtained by means of hydrolysis of apramycin.
    Type: Grant
    Filed: October 22, 1981
    Date of Patent: December 7, 1982
    Assignee: Shionogi & Co., Ltd.
    Inventors: Kikuo Igarashi, Tsunetoshi Honma
  • 5-Deoxyapramycin
    Patent number: 4358585
    Abstract: Novel 5-deoxyapramycin having the reinforced antimicrobial activity against gram-positive and negative bacteria with less side effects, resulted from reductive removal of 5-hydroxy group of apramycin through halogenation.
    Type: Grant
    Filed: October 22, 1981
    Date of Patent: November 9, 1982
    Assignee: Shionogi & Co., Ltd.
    Inventors: Kikuo Igarashi, Tsunetoshi Honma, Tamio Sugawara
  • Process for preparing aminoglycoside derivatives
    Patent number: 4273923
    Abstract: Novel aminoglycoside derivatives and their salts containing 2-deoxystreptamine moiety and 4',5'-unsaturation effective in treatment and prevention of infectious diseases caused by gram-positive and gram-negative bacteria.
    Type: Grant
    Filed: August 20, 1979
    Date of Patent: June 16, 1981
    Assignee: Shionogi & Co., Ltd.
    Inventors: Kikuo Igarashi, Tamio Sugawara
  • Novel aminoglycoside derivatives
    Patent number: 4248865
    Abstract: Novel aminoglycoside derivatives and their salts containing 2-deoxystreptamine moiety, of which the 1-amino group is modified with a group represented by the formula: ##STR1## (wherein R is hydrogen or C.sub.1 to C.sub.6 alkanoyl; and n is an integer of 1 to 3.)effective in treatment and prevention of infectious diseases caused by gram-positive and gram-negative bacteria.
    Type: Grant
    Filed: August 20, 1979
    Date of Patent: February 3, 1981
    Assignee: Shionogi & Co., Ltd.
    Inventors: Kikuo Igarashi, Tsunetoshi Honma
  • Novel aminoglycoside derivatives
    Patent number: 4201774
    Abstract: Novel aminoglycoside derivatives and their salts, of which the 1-amino group is modified with groups represented by the formula: ##STR1## (wherein R is hydrogen, lower alkyl, or aralkyl; and n is an integer of 1 to 3.) effective in treatment and prevention of infectious diseases caused by gram-positive and gram-negative bacteria.
    Type: Grant
    Filed: November 14, 1978
    Date of Patent: May 6, 1980
    Assignee: Shionogi & Co., Ltd.
    Inventors: Kikuo Igarashi, Tamio Sugawara
  • Novel aminoglycoside derivatives
    Patent number: 4200628
    Abstract: Novel aminoglycoside derivatives and their salts containing 2-deoxystreptamine moiety, of which the 1-amino group is acylated by a group represented by the formula: ##STR1## (wherein R is 4 to 6 membered heterocyclic group containing 1 to 2 nitrogen atoms which may optionally be substituted.) effective in treatment of infectious diseases caused by gram positive and gram negative bacteria.
    Type: Grant
    Filed: September 19, 1978
    Date of Patent: April 29, 1980
    Assignee: Shionogi & Co., Ltd.
    Inventors: Kikuo Igarashi, Junji Irisawa, Tsunetoshi Honma
  • 1-N-Hetero containing aminoglycoside derivatives
    Patent number: 4199570
    Abstract: Novel aminoglycoside derivatives and their salts containing 2-deoxystreptamine moiety, of which the 1-amino group is acylated by a group represented by the formula: ##STR1## wherein R is hydrogen, lower alkyl, aralkyl, or aralkoxycarbonyl; andn is an integer of 1 or 3,effective in treatment and prevention of infectious diseases caused by gram positive and gram negative bacteria.
    Type: Grant
    Filed: August 17, 1978
    Date of Patent: April 22, 1980
    Assignee: Shionogi & Co., Ltd.
    Inventors: Kikuo Igarashi, Junji Irisawa
  • Aminoglycoside antibiotic derivatives and method of use
    Patent number: 4166114
    Abstract: Novel aminoglycoside antibiotic derivatives and their salts containing a 2-deoxystreptamine moiety of which the 1-amino group is substituted by a group represented by the formula: ##STR1## [wherein R is hydrogen atom, lower alkyl or aralkyl; n is an integer 1 or 2]Are effective in treatment and prevention of infectious diseases caused by gram positive and negative bacteria.
    Type: Grant
    Filed: September 29, 1977
    Date of Patent: August 28, 1979
    Assignee: Shionogi & Co., Ltd.
    Inventor: Kikuo Igarashi