Patents by Inventor Killian S. Hanlon

Killian S. Hanlon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant adeno associated virus encoding clarin-1 and uses thereof
    Patent number: 12129287
    Abstract: Aspects of the disclosure relate to compositions and methods for treating hereditary hearing loss and/or vision loss, for example, due to Usher syndrome, Type 3A. In some embodiments, the disclosure provides a recombinant adeno-associated virus comprising: (i) an AAV-S capsid protein, and (ii) an isolated nucleic acid comprising a transgene (e.g., a transgene for expressing a clarin-1 protein). The present disclosure also provides methods of treating hereditary hearing loss and/or vision loss (e.g., Usher Syndrome, Type 3A) using the same.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: October 29, 2024
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David P. Corey, Casey A. Maguire, Killian S. Hanlon, Maryna V. Ivanchenko
  • AAV Capsids and Uses Thereof
    Publication number: 20240209394
    Abstract: Described herein are capsid peptides that mediated efficient AAV transduction of the brain vasculature, mainly endothelial cells and pericytes, as well as smooth muscle cells, compositions (including AAV), and methods of using the same. Embodiments of the invention encompass AAV capsid proteins comprising an amino acid sequence that comprises at least four, at least five, or at least six contiguous amino acids from the sequence PRPPSTH (SEQ ID NO: 1); MAEPGAR (SEQ ID NO: 2); SQDPSTL (SEQ ID NO: 3); or MLYADNT (SEQ ID NO: 4).
    Type: Application
    Filed: April 27, 2022
    Publication date: June 27, 2024
    Inventors: Patricia L. Musolino, Casey A. Maguire, Eloise Hudry, Killian S. Hanlon
  • ENGINEERED ADENO-ASSOCIATED (AAV) VECTORS FOR TRANSGENE EXPRESSION
    Publication number: 20220195458
    Abstract: Engineered AAV vectors for transgene expression, e.g., in the CNS, PNS, inner ear, heart, or retina, and methods of use thereof. Also provided are methods for discovering new engineered AAV vectors that mediate transgene expression in desired cell types.
    Type: Application
    Filed: March 30, 2020
    Publication date: June 23, 2022
    Inventors: Casey A. Maguire, Eloise Marie Hudry, Killian S. Hanlon
  • RECOMBINANT ADENO ASSOCIATED VIRUS ENCODING CLARIN-1 AND USES THEREOF
    Publication number: 20220119475
    Abstract: Aspects of the disclosure relate to compositions and methods for treating hereditary hearing loss and/or vision loss, for example, due to Usher syndrome, Type 3A. In some embodiments, the disclosure provides a recombinant adeno-associated virus comprising: (i) an AAV-S capsid protein, and (ii) an isolated nucleic acid comprising a transgene (e.g., a transgene for expressing a clarin-1 protein). The present disclosure also provides methods of treating hereditary hearing loss and/or vision loss (e.g., Usher Syndrome, Type 3A) using the same.
    Type: Application
    Filed: September 14, 2021
    Publication date: April 21, 2022
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David P. Corey, Casey A. Maguire, Killian S. Hanlon, Maryna V. Ivanchenko